Inborn errors of IL-12/23- and IFN-γ-mediated immunity: molecular, cellular, and clinical features

Filipe-Santos, Orchidée; Bustamante, Jacinta; Chapgier, Ariane; Vogt, Guillaume; Beaucoudrey, Ludovic de; Feinberg, Jacqueline; Jouanguy, Emmanuelle; Boisson–Dupuis, Stéphanie; Fieschi, Claire; Pïcard, Capucine; Casanova, Jean‐Laurent

doi:10.1016/j.smim.2006.07.010

Cited by 416 publications

(246 citation statements)

References 142 publications

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“…Our data provide evidence for an essential role of a protective IL-23/IL-22 axis in a Th1-compromised state that may be relevant for patients with an inherited defect in the IL-12/IL-12R/IFN-␥ pathway suffering from recurrent infections (reviewed in Ref. 7). (60).…”

mentioning

confidence: 72%

“…application of a high sublethal infective dose of this attenuated S. Enteritidis strain (i.e., 2.5 ϫ 10 6 CFU for WT C57BL/6 mice) and of a low sublethal infective dose (i.e., 2.5 ϫ 10 3 CFU for IL-12-deficient C57BL/6 mice), either mouse strain survives and does not develop a typhoid-like disease. These two different experimental models are suitable for studies comparing immunoregulatory mechanisms in the presence and particularly in the absence of IL-12, as is the case in human patients with IL-12/ IL-23 defects leading to recurrent salmonellosis (7). IL-12 produced by Salmonella-infected dendritic cells and macrophages is the key cytokine for Th1 cell development.…”

mentioning

confidence: 99%

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Protective Immunity to Systemic Infection with AttenuatedSalmonella entericaserovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17

Schulz

Köhler

Schütze

et al. 2008

The Journal of Immunology

108

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IL-12 is essential for protective T cell-mediated immunity against Salmonella infection. To characterize the role of the related cytokine IL-23, wild-type (WT) C57BL/6 and p19−/− mice were infected systemically with an attenuated strain of Salmonella enterica serovar Enteritidis (S. Enteritidis). IL-23-deficient mice controlled infection with S. Enteritidis similarly as WT mice. Similar IFN-γ production as compared with WT mice, but defective IL-17A and IL-22 production was found in the absence of IL-23. Nevertheless, although IL-23 is required for T cell-dependent cytokine responses, IL-23 is dispensable for protection against S. Enteritidis when IL-12 is present. To analyze the role of IL-23 in the absence of IL-12, low doses of S. Enteritidis were administered to p35−/− mice (lacking IL-12), p35/19−/− mice (lacking IL-12 and IL-23), p35/40−/− mice (lacking IL-12, IL-23, and homodimeric IL-12p40), or p35/IL-17A−/− mice (lacking IL-12 and IL-17A). We found survival of p35−/− and p35/IL-17A−/− mice, whereas p35/19−/− and p35/40−/− mice died within 3–6 wk and developed liver necrosis. This indicates that IL-23, but not homodimeric IL-12p40, is required for protection, which, surprisingly, is independent of IL-17A. Moreover, protection was associated with IL-22, but not IL-17F or IL-21 expression or with neutrophil recruitment. Finally, anti-IL-22 treatment of S. Enteritidis-infected p35−/− mice resulted in liver necrosis, indicating a central role of IL-22 in hepatocyte protection during salmonellosis. In conclusion, IL-23-dependent IL-22, but not IL-17 production is associated with protection against systemic infection with S. Enteritidis in the absence of IL-12.

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mentioning

confidence: 72%

mentioning

confidence: 99%

Protective Immunity to Systemic Infection with AttenuatedSalmonella entericaserovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17

Schulz

Köhler

Schütze

et al. 2008

The Journal of Immunology

108

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“…In addition, activating receptors that transmit signals through ITAMs have the ability to induce IFN-g production (7). IFN-g in turn promotes the activation of macrophages (8), shapes the innate and adaptive immune responses (9), and suppresses the proliferation of tumor and virus-infected cells (10). Freshly isolated NK cells from humans and mice have only minimal cytotoxicity and secrete a low level of IFN-g (11).…”

mentioning

confidence: 99%

Suppressor of Cytokine Signaling 2 Regulates IL-15–Primed Human NK Cell Function via Control of Phosphorylated Pyk2

Lee

Yun

Piao

et al. 2010

The Journal of Immunology

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NK cells are capable of killing virus-infected or tumor cells and producing IFN-γ. Resting NK cells, however, have only minimal cytolytic activity and secrete a low level of IFN-γ. The cytokine IL-15 can promote the expression of effector functions by resting NK cells. In this study, we demonstrate that suppressor of cytokine signaling 2 (SOCS2) has a novel role in IL-15–primed human NK cell function. SOCS2 expression was upregulated in NK cells following stimulation with IL-15. During IL-15–mediated NK cell priming, SOCS2 interacted with phosphorylated proline-rich tyrosine kinase 2 (Pyk2) at tyrosine 402 (p-Pyk2Tyr402) and induced the proteasome-mediated degradation of p-Pyk2Tyr402 via ubiquitination. Knockdown of SOCS2 resulted in the accumulation of p-Pyk2Tyr402 and blocked NK cell effector functions. In addition, NK cell cytolytic activity and IFN-γ production were inhibited by overexpression of the wild-type of Pyk2 but not by the overexpression of tyrosine 402 mutant of Pyk2. These results suggest that SOCS2 regulates human NK cell effector functions via control of phosphorylated Pyk2 depending on IL-15 existence.

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“…With the exception of CYBB, MSMDcausing genes encode molecules involved in the IL-12-IFNγcircuit (33). These rare disorders have been diagnosed in over 220 patients from over 43 countries worldwide with inborn errors of the IL-12/23-IFN-gamma circuit (34).…”

Section: Mendelian Susceptibility To Mycobacterial Diseases (Msmd)mentioning

confidence: 99%

BCG Vaccination as a Prevention Strategy, Threats and Benefits

Shirvani

Karimi

Rajabnejad

2016

Arch Pediatr Infect Dis

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Context: Tuberculosis is still one of the deadliest communicable diseases. Objectives: Nine million people worldwide developed TB in 2013, and 1.5 million people died from it, 360000 of which were HIV positive. Although the disease is controllable by means of diagnostic and treatment measures, the death toll from the disease is still high, and efforts to combat it must be accelerated. Data Sources: Data compiled from 202 countries in the Global Tuberculosis Report 2014 showed that TB is present in all regions of the world. Study Selection: Higher numbers of tuberculosis cases were diagnosed in 2013 in comparison with previous reports, indicating that diagnoses and reports of new cases may be improved by stringent data collection. Data Extraction: A special note to the 2014 report highlighted the progress of drug resistant TB during the last two decades. Results: Worldwide, a proportion of new cases with multidrug-resistant TB (MDR-TB) were reported at 3.5% in 2013 without a significant change compared with recent years. Interestingly, higher levels of resistance and poor treatment outcomes are of major concern in some parts of the world. Due to this concern, special attention is focused on prevention rather than treatment. On the other hand, the effectiveness of an existing vaccine (BCG) is increasingly questionable. Conclusions: It has the potential to cause disseminated infection, and an increasing number of immunocompromised patients prone to disease and the suboptimal preventive potency of this vaccine suggest the need for a global attempt to review its benefits and disadvantages.

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Inborn errors of IL-12/23- and IFN-γ-mediated immunity: molecular, cellular, and clinical features

Cited by 416 publications

References 142 publications

Protective Immunity to Systemic Infection with AttenuatedSalmonella entericaserovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17

Protective Immunity to Systemic Infection with AttenuatedSalmonella entericaserovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17

Suppressor of Cytokine Signaling 2 Regulates IL-15–Primed Human NK Cell Function via Control of Phosphorylated Pyk2

BCG Vaccination as a Prevention Strategy, Threats and Benefits

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