Inbreeding removes sex differences in lifespan in a population of
            <i>Drosophila melanogaster</i>

Carazo, Pau; Green, Jared; Sepil, Irem; Pizzari, Tommaso; Wigby, Stuart

doi:10.1098/rsbl.2016.0337

Cited by 31 publications

(53 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, an effect of inbreeding per se on the expression of male versus female lifespan has been observed [20]. We reduced the potential for inbreeding through maintenance at large population sizes.…”

Section: Discussionmentioning

confidence: 99%

Manipulation of feeding regime alters sexual dimorphism for lifespan and reduces sexual conflict in Drosophila melanogaster

2017

View full text Add to dashboard Cite

Sexual dimorphism for lifespan (SDL) is widespread, but poorly understood. A leading hypothesis, which we test here, is that strong SDL can reduce sexual conflict by allowing each sex to maximize its sex-specific fitness. We used replicated experimental evolution lines of the fruit fly, Drosophila melanogaster, which had been maintained for over 360 generations on either unpredictable ‘Random’ or predictable ‘Regular’ feeding regimes. This evolutionary manipulation of feeding regime led to robust, enhanced SDL in Random over control, Regular lines. Enhanced SDL was associated with a significant increase in the fitness of focal males, tested with wild-type (WT) females. This was due to sex-specific changes to male life history, manifested as increased early reproductive output and reduced survival. In contrast, focal female fitness, tested with WT males, did not differ across regimes. Hence increased SDL was associated with a reduction in sexual conflict, which increased male fitness and maintained fitness in females. Differences in SDL were not associated with developmental time or developmental survival. Overall, the results showed that the expression of enhanced SDL, resulting from experimental evolution of feeding regimes, was associated with male-specific changes in life history, leading to increased fitness and reduced sexual conflict.

show abstract

Section: Discussionmentioning

confidence: 99%

Manipulation of feeding regime alters sexual dimorphism for lifespan and reduces sexual conflict in Drosophila melanogaster

2017

View full text Add to dashboard Cite

show abstract

“…from adjusted LMs) with inbreeding (outbred vs inbred treatment) separately for the sexes, including or not the mixed‐sexes treatment: (A) in this experiment, (B) in Carazo et al. () and (C) in data pooled from both experiments. In each case, we provide the significance level (or exact P ‐value when marginal) of the corresponding model.…”

Section: Resultsmentioning

confidence: 99%

“…; Carazo et al. ). Using Drosophila melanogaster , we contribute to this budding corpus of research by testing a fundamental prediction of the UXh: that inbreeding will have maladaptive sex‐specific effects on female lifespan.…”

Section: Discussionmentioning

confidence: 98%

“…Unfortunately, and despite suggestive correlative evidence at a broad comparative level, experimental investigations of the UXh have lagged behind, and direct empirical support for the UXh is simply scarce and inconsistent (Maklakov and Lummaa ; Carazo et al. ).…”

mentioning

confidence: 99%

“…) and in Drosophila melanogaster (Carazo et al. ). In seed beetles, results are inconsistent with the “unguarded‐X” and seem better explained by sexually divergent selection (Fox et al.…”

mentioning

confidence: 99%

See 2 more Smart Citations

The “unguarded-X” and the genetic architecture of lifespan: Inbreeding results in a potentially maladaptive sex-specific reduction of female lifespan inDrosophila melanogaster

2018

Self Cite

View full text Add to dashboard Cite

Sex differences in ageing and lifespan are ubiquitous in nature. The "unguarded-X" hypothesis (UXh) suggests they may be partly due to the expression of recessive mutations in the hemizygous sex chromosomes of the heterogametic sex, which could help explain sex-specific ageing in a broad array of taxa. A prediction central to the UX hypothesis is that inbreeding will decrease the lifespan of the homogametic sex more than the heterogametic sex, because only in the former does inbreeding increase the expression of recessive deleterious mutations. In this study, we test this prediction by examining the effects of inbreeding on the lifespan and fitness of male and female Drosophila melanogaster across different social environments. We found that, across social environments, inbreeding resulted in a greater reduction of female than male lifespan, and that inbreeding effects on fitness did not seem to counterbalance sex-specific effects on lifespan, suggesting the former are maladaptative. Inter- and intra-sexual correlation analyses also allowed us to identify evidence of an underlying joint genetic architecture for inbreeding effects on lifespan. We discuss these results in light of the UXh and other alternative explanations, and suggest that more attention should be paid to the possibility that the "unguarded-X" may play an important role in the evolution of sex-specific lifespan.

show abstract

Sex‐specific outbreeding advantages and sexual dimorphism in the seedlings of dioecious trees

Zhang

Wei

Chu

et al. 2023

American J of Botany

View full text Add to dashboard Cite

Premise Dioecious trees are important components of many forest ecosystems. Outbreeding advantage and sexual dimorphism are two major mechanisms that explain the persistence of dioecious plants; however, they have rarely been studied in dioecious trees. Methods We investigated the influence of sex and genetic distance between parental trees (GDPT) on the growth and functional traits of multiple seedlings of a dioecious tree, Diospyros morrisiana. Results We found significant positive relationships between GDPT and seedling sizes and tissue density. However, the positive outbreeding effects on seedling growth mainly manifested in female seedlings, but were not prominent in males. Among seedlings, the male ones generally had higher biomass and leaf area than female seedlings, but such differences diminished as GDPT increased. Conclusions Our research highlights that outbreeding advantage in plants can be sex‐specific and that sexual dimorphism begins from the seedling stage of dioecious trees.

show abstract

Inbreeding removes sex differences in lifespan in a population of Drosophila melanogaster

Cited by 31 publications

References 19 publications

Manipulation of feeding regime alters sexual dimorphism for lifespan and reduces sexual conflict in Drosophila melanogaster

Manipulation of feeding regime alters sexual dimorphism for lifespan and reduces sexual conflict in Drosophila melanogaster

The “unguarded-X” and the genetic architecture of lifespan: Inbreeding results in a potentially maladaptive sex-specific reduction of female lifespan inDrosophila melanogaster

Sex‐specific outbreeding advantages and sexual dimorphism in the seedlings of dioecious trees

Contact Info

Product

Resources

About