2014
DOI: 10.3791/50791
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Inchworming: A Novel Motor Stereotypy in the BTBR <em>T<sup>+</sup> Itpr3<sup>tf</sup></em>/J Mouse Model of Autism

Abstract: Autism Spectrum Disorder (ASD) is a behaviorally defined neurodevelopmental disorder characterized by decreased reciprocal social interaction, abnormal communication, and repetitive behaviors with restricted interest. As diagnosis is based on clinical criteria, any potentially relevant rodent models of this heterogeneous disorder should ideally recapitulate these diverse behavioral traits. The BTBR T + Itpr3 tf /J (BTBR) mouse is an established animal model of ASD, displaying repetitive behaviors such as incre… Show more

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Cited by 8 publications
(6 citation statements)
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“…Most cases of ASD have unknown genetic underpinnings (Gaugler et al, 2014 ), and models of unidentified etiology have been characterized with behavioral tests assessing autistic symptomatology. The BTBR T+tf/J (BTBR) inbred mouse strain is one of the most clinically relevant animal models of autism; it was identified in an extensive effort to characterize ASD-like behaviors in ten inbred mouse strains (Moy et al, 2007 ) and displays all the core behavioral features that define the disorder (Moy et al, 2007 ; McFarlane et al, 2008 ; Meyza et al, 2013 ; Ruskin et al, 2013 ; Smith et al, 2014 ; Ellegood and Crawley, 2015 ). BTBR mice display deficits in social interaction and communication assays and exhibit repetitive and stereotyped behaviors.…”
Section: Metabolic Therapy and Asd—evidence From Animal Modelsmentioning
confidence: 99%
“…Most cases of ASD have unknown genetic underpinnings (Gaugler et al, 2014 ), and models of unidentified etiology have been characterized with behavioral tests assessing autistic symptomatology. The BTBR T+tf/J (BTBR) inbred mouse strain is one of the most clinically relevant animal models of autism; it was identified in an extensive effort to characterize ASD-like behaviors in ten inbred mouse strains (Moy et al, 2007 ) and displays all the core behavioral features that define the disorder (Moy et al, 2007 ; McFarlane et al, 2008 ; Meyza et al, 2013 ; Ruskin et al, 2013 ; Smith et al, 2014 ; Ellegood and Crawley, 2015 ). BTBR mice display deficits in social interaction and communication assays and exhibit repetitive and stereotyped behaviors.…”
Section: Metabolic Therapy and Asd—evidence From Animal Modelsmentioning
confidence: 99%
“…It is also critical to look beyond the boundaries of the rudimentary behaviors that have been defined in the literature. Inch-worming, a novel pattern of digging, has been reported in BTBR mice that can recapitulate compulsive behaviors in humans ( 354 ). With persistent digging commonly observed across the HA strains, micro-behaviors within a general behavioral domain can elucidate several aspects of repetitiveness.…”
Section: Discussionmentioning
confidence: 99%
“…Although these methods indeed provide additional information about mouse behavior, they are not widely adopted and they do not quantify the spatio-temporal characteristics of the burying bouts. A few studies, which report burying and digging events, label them by manually annotating the video frames ( Wright-Williams et al, 2013 ; Smith et al, 2014 ; Serra et al, 2021 ), which is an accurate but highly time-consuming method.…”
Section: Introductionmentioning
confidence: 99%