Incidence and Antibiotic Susceptibility Pattern of Most Common Bacterial Pathogen Causing Urinary Tract Infection (UTI) in Tehran, IRAN, 2012-2013

Piranfar, Vahhab; Mirnejad, Reza; Erfani, Mohammad

doi:10.17795/ijep15490

Cited by 11 publications

(15 citation statements)

References 14 publications

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“…and Proteus mirabilis, high rates of antibiotic resistance were observed for nalidixic acid and tetracycline, respectively. Similar studies in Iran showed different results regarding the antibiotic-sensitivity patterns in UTIs (20)(21)(22)(23). Khoshbakht et al (2012) reported a higher rate of positive cultures in women compared to men (88.69% versus 11.3%), which is similar to our findings.…”

Section: Discussionsupporting

confidence: 89%

“…They also suggested E. coli as the major cause of UTI, showing the highest rate of resistance against cephalothin (88.16%), which is higher compared to our study (54.33%) (20). A study carried out by Piranfar et al (2014) showed E. coli as the main cause of UTIs, and it was mostly resistant to co-trimoxazole (23). Based on the results of the present study, E. coli is the prevalent causative agent of UTI and is highly resistant against ampicillin and erythromycin.…”

Section: Discussioncontrasting

confidence: 47%

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Prevalence and Antibiotic Susceptibility Patterns of Urinary Tract Infections in Patients Referred to a Clinical Laboratory in Isfahan, Iran, 2014 - 2015

Sadeghpour¹,

Sharifi²,

Estaji³

et al. 2016

Avicenna J Clin Microbiol Infect

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Objectives: The aim of this study was to determine the prevalence of bacterial urinary tract infections (UTIs) and their antibiotic resistance patterns among patients referred to a clinical laboratory in Isfahan, Iran, during 2014Iran, during -2015. Methods: In this retrospective study, the data of urine culture tests which were performed from May 2014 to March 2015 at the Dr. Sharifi Clinical Laboratory were recorded and analyzed. A total of 4,506 patients with urine culture testing were included. Antimicrobial susceptibility testing was performed by the disk diffusion method according to the CLSI criteria. The gathered data were then analyzed with SPSS software using descriptive tests. Results: Among the 4,506 studied patients with urine cultures, 300 (6.65%) and 4,206 (93.35%) urine samples showed positive and negative bacterial growth, respectively. The rates of urine cultures with bacterial growth for women and men were 90.66% and 9.44%, respectively. With regard to the bacterial growth, 90.33% were Gram-negative and 9.67% were Gram-positive. The most common isolated agent was Escherichia coli, followed by Klebsiella spp. The highest rate of resistance was seen for penicillin and ampicillin in all isolates, and the lowest resistance rate was observed for ciprofloxacin and gentamycin. Conclusions:The results of the present study showed that antimicrobial resistance among the causative agents of UTIs is high in Isfahan, and treatment of UTIs based on antibiotic-susceptibility test results can be suggested.Keywords: Urinary Tract Infection, Drug Resistance, Iran BackgroundUrinary tract infections (UTIs) are amongst the most widespread types of bacterial infections throughout the world (1). They are associated with a high rate of morbidity and economic costs associated with treatment (2). UTIs may involve the kidneys, ureters, bladder, and urethra (3). They may be symptomatic or asymptomatic, which, if left untreated, can lead to serious consequences (4). It is estimated that 150 million people suffer from UTIs annually (3,5). Although different microorganisms (Candida albicans, Trichomonas vaginalis, and a variety of bacteria) can cause UTIs, bacteria are suspected as the major cause (6).Some studies suggest that the most common cause of uncomplicated community-acquired uropathogenesis is Escherichia coli (> 80%) (3). Other pathogens that cause UTIs include Staphylococcus saprophyticus, Klebsiella spp., Proteus mirabilis, and Enterococcus faecalis (7). Rapid and accurate diagnosis of UTI can be helpful in shortening the disease duration and for the prevention of complications, such as renal failure (8). Early diagnosis of acute uncomplicated cystitis is based on the patient's medical history, family and individual health information, sexual activity, and recent symptoms. Although the medical history and urine analysis are sufficient for a diagnosis of uncomplicated UTI, the gold standard is urine bacterial culture with antibioticsusceptibility testing (1). Sadeghpour S et al.Treatment of UTI is base...

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Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 47%

Prevalence and Antibiotic Susceptibility Patterns of Urinary Tract Infections in Patients Referred to a Clinical Laboratory in Isfahan, Iran, 2014 - 2015

Sadeghpour¹,

Sharifi²,

Estaji³

et al. 2016

Avicenna J Clin Microbiol Infect

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“…Likewise, many scientists reported E. coli as common pathogenic isolates in UTI (12,(19)(20)(21); however, in some geographic regions such as Nigeria (Ebonyi State university teaching hospital, Children's emergency unit, age group between birth to five years old) Klebsiella spp was reported as the main factor of UTI in children (22). In Iran, Monsef and Eghbalian and Mirsoleymani et al reported Klebsiella spp as the second factor for UTI besides E. coli (Ekbatan hospital of the Hamadan University of Medical Sciences, neonatal and neonatal intensive care unit, age group between one to 30 days), as shown in our study (11,16).…”

Section: Discussionmentioning

confidence: 99%

Bacterial Etiologies and Antibiotic Susceptibility Pattern of Urinary Tract Infections at the Pediatric Ward of Dastgheib Hospital, Shiraz, Iran: A Three-Year Study (2009 - 2011)

Motamedifar

Zamani

Hassanzadeh

et al. 2016

Arch Clin Infect Dis

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“…Pneumonia are the commonest pathogens isolated in patient with urinary tract infections. [12,13,14,15] However there was marked increase in the UTI cases due to Proteus species during 2014 was noticed, thereby suggesting hospital acquired infection. Among the gram positive bacteria there is a change in microbial spectrum during the study period as shown in Table: 4.…”

Section: Antibiotics Enterococcus Species Coagulase Negativementioning

confidence: 99%

Changing Prevalence and Antimicrobial Susceptibility Profiles by Uropathogens : A Study in India

Kalaiselvi¹,

Shanmugavadivoo²,

Padmavathi³

et al. 2015

jemds

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AIM:To analyse the changing spectrum of uropathogens isolated from clean catch midstream urine samples and to evaluate the antibiotic sensitivity pattern & Multi drug resistance of those isolates. MATERIALS AND METHODS: All the urine samples collected in sterile container were received during the study period from Jan 2013 to Dec 2014 were processed & all the pathogenic isolates were identified as per the standard guideline. Antibiotic sensitivity was performed for the identified pathogens according to CLSI standards. RESULTS: A total 2306 urine specimens were processed and 43.06% showed significant bacteriuria among which 31.78% revealed GNB bacteriuria and 11.28% revealed GPC bacteriuria. The most frequently isolated pathogens were E.coli (27.8%), Klebsiella (16.7%) & Pseudomonas (6.0%) among GNB and Enterococci (11.9%) followed by CONS (8.6%) among GPC. Sensitivity tested against various antimicrobials to gram negative bacilli showed maximum sensitivity against Imipenem, Nitrofurantoin and Amikacin in order of sensitivity. Gram positive cocci showed maximum sensitivity against Vancomycin, Nitrofurantoin and Gentamicin respectively. Multidrug resistance was observed in all isolated pathogens. CONCLUSION: In this study we observed that there was a gradual shift in the prevalence of the isolated uropathogens and its antimicrobial sensitivity pattern. The reasons for this shift can be framed out as either more frequent and unnecessary usage of antibiotics or prescribing newer antibiotics with newer combinations for faster recovery of infections. Overall, both gram positive and gram negative organisms were most susceptible to Nitrofurantoin (Apart from Vancomycin in gram positives).

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Incidence and Antibiotic Susceptibility Pattern of Most Common Bacterial Pathogen Causing Urinary Tract Infection (UTI) in Tehran, IRAN, 2012-2013

Cited by 11 publications

References 14 publications

Prevalence and Antibiotic Susceptibility Patterns of Urinary Tract Infections in Patients Referred to a Clinical Laboratory in Isfahan, Iran, 2014 - 2015

Prevalence and Antibiotic Susceptibility Patterns of Urinary Tract Infections in Patients Referred to a Clinical Laboratory in Isfahan, Iran, 2014 - 2015

Bacterial Etiologies and Antibiotic Susceptibility Pattern of Urinary Tract Infections at the Pediatric Ward of Dastgheib Hospital, Shiraz, Iran: A Three-Year Study (2009 - 2011)

Changing Prevalence and Antimicrobial Susceptibility Profiles by Uropathogens : A Study in India

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