Incidence and Characteristics of Thyroid Dysfunction Following Interferon Therapy in Patients with Chronic Hepatitis C.

Amenomori, Masahiro; Mori, Toru; Fukuda, Yoshihiro; Sugawa, Hideo; Nishida, Naoshi; Furukawa, Motonobu; Kita, Ryuichi; Sando, Takehiro; Komeda, Toshiki; Nakao, Kazuwa

doi:10.2169/internalmedicine.37.246

Cited by 18 publications

(8 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Contrastes iodados: O principal efeito de alguns contrastes radiológicos é a inibição da conversão pe -Interferon e Interleucinas: O uso das citoquinas tem sido associado com o desenvolvimento tanto de hipo como de hipertireoidismo (71,72). São drogas utilizadas no tratamento de doenças infecciosas como hepatite e também em neoplasias como melanoma e carcinoma de células renais.…”

Section: Doença Não Tireoideanaunclassified

Fatores Interferentes na Interpretação de Dosagens Laboratoriais no Diagnóstico de Hiper e Hipotireoidismo

Graf

Carvalho

2002

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

Laboratory Interfering Factors in the Diagnosis of Hyper and Hypothyroidism.Since the first reports in the medical literature describing the clinical presentation of hypo and hyperthyroidism, very little has changed on the semiologic scenario of these entities and even in their therapeutic approach. The changing trends refer much more to the tools used to diagnose thyroid disease. In parallel with these developments, we understand much better about the factors that interfere in the interpretation of thyroid function tests in the diagnosis of hyper and hypothyroidism. In this article, we analyzed the utility of serum TSH and thyroid hormone measurements, as well the pitfalls and interferences in its common daily use. (Arq Bras Endocrinol Metab 2002;46/1:51-64)

show abstract

Section: Doença Não Tireoideanaunclassified

Fatores Interferentes na Interpretação de Dosagens Laboratoriais no Diagnóstico de Hiper e Hipotireoidismo

Graf

Carvalho

2002

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

show abstract

“…[333][334][335][336][337] They are used in the treatment of infectious diseases such as hepatitis, as well as in malignancies, including melanoma and renal cell carcinoma. Acute administration has been used as a model of illness because the effects are similar: interferon-α leads to a decrease in T3, an increase in rT3, and a decrease in TSH.…”

Section: Immune-modulating Drugsmentioning

confidence: 99%

“…The incidence is much greater in females and in patients with positive TPO antibodies before the initiation of therapy. 333,335,336 During therapy, patients who were antibody positive can have a rise in titer, whereas antibody positivity can develop in patients with previously negative antibodies. In patients who are treated with interferon, the incidence of thyroid disease is much higher in those with hepatitis C than in those with hepatitis B. Thyrotoxicosis often occurs as a manifestation of a destructive thyroiditis.…”

Section: Immune-modulating Drugsmentioning

confidence: 99%

Thyroid Function Testing

Weiss¹,

Refetoff

2016

Endocrinology: Adult and Pediatric

View full text Add to dashboard Cite

“…Smatra se da postoji genetska predispozicija za upalni odgovor tiroidee tokom infekcije različitim virusima [10]. Opisani su i slučajevi subakutnog tiroidita kod pacijenata lečenih imunomodulatornim terapijama (interleukin 2, TNF, α i γ interferon) [11], kao i kod pacijenata nakon primene kontrastnih sredstava za radiološka ispitivanja [12]. SAT je redak kod dece [13].…”

Section: Uvodunclassified

Atypical subacute thyroiditis and functional thyroid adenoma: Case report

Aleksić¹,

Ristovic²,

Aleksić³

2014

Tim Med Glas

View full text Add to dashboard Cite

Sažetak:Subakutni tiroiditis (SAT), poznat i kao DeQuervain-ov ili granulomatozni tiroiditis, je upalno stanje štitaste ţlezde, koja je obično zahvaćena u celini. Tipično se javlja jak bol i osetljivost u tiroidnoj loţi praćeno slabošću, zamaranjem, bolovima u mišićima i zglobovima, i lako do umereno povišenom telesnom temperaturom, kao i simptomima tirotoksikoze -nervoza, pojačano znojenje, ubrzan rad srca i drhtanje. Patognomična za SAT je prolazna hipertiroksinemija, suprimiran TSH i povišeni serumski markeri inflamacije u akutnoj fazi, uz difuzno odsutno vezivanje radiojoda ili tehnecijum-pertehnetata u štitastoj ţlezdi zbog destrukcije tirocita. Opisani su retki slučajevi atipičnog SAT -bezbolnog, ili s minimalnim bolovima, SAT ograničenog na jedan reţanj tiroidee, ili fokalnog tiroiditisa. Prikazujemo redak slučaj minimalno bolnog SAT udruţenog sa funkcijskim adenomom u desnom reţnju štitaste ţlezde, koji se u tirotoksičnoj fazi scintigrafski prezentovao kao toksični adenom, a, u stvari, predstavlja tkivo funkcijskog adenoma nezahvaćenog destruktivnim tiroiditisom. Ključne reči:atipični subakutni tiroiditis, autonomni funkcijski nodus, toksični adenom. Summary:Subacute thyroiditis (SAT), also known as DeQuervain's or granulomatous thyroiditis is an inflammatory condition of the thyroid gland, which is usually fully affected. Severe pain and tenderness in the thyroid bed occur typically and are followed by weakness, fatigue, pain in muscles and joints, and light to moderate fever and symptoms of thyrotoxicosis -nervousness, sweating and rapid heartbeat and trembling. Temporary elevated serum thyroxine, suppressed TSH and elevated serum markers of inflammation in the acute phase are pathognomonic for the SAT, with diffusely absent binding of radioactive iodine or technetiumpertechnetate in the thyroid gland due to thyrocytes destruction. Rare cases of atypical SAT -painless or with minimal pain, SAT limited to one thyroid lobe or focal thyroiditis, are reported in literature. We report a rare case of a minimally painful SAT associated with functional adenoma in the right lobe of the thyroid gland, which was, in thyrotoxic, acute phase, scintigraphicaly presented as toxic adenoma, in fact representing a functional adenoma tissue unaffected by destructive thyroiditis. Keywords:atypical subacute thyroiditis, autonomously functioning thyroid nodule, toxic adenoma UVOD Subakutni tiroiditis (SAT), poznat i kao DeQuervain-ov ili granulomatozni tiroidit, je upalno stanje štitaste ţlezde, koja je obično zahvaćena u celini. Moţe trajati od nekoliko nedelja, do nekoliko meseci. Verovatno je virusnog porekla, opisano je i epidemijsko oboljevanje, prolazi spontano, a moţe i da recidivira. Najčešće pogaĎa ţene izmeĎu pete i šeste decenije ţivota. Tipično se javlja jak bol i osetljivost u tiroidnoj loţi praćeno slabošću, zamaranjem, bolovima u mišićima i zglobovima, i lako do umereno povišenom telesnom temperaturom, kao i simptomi tirotoksikoze -nervoza, pojačano znojenje, ubrzan rad srca i drhtanje. Opisani su retki sluča...

show abstract

Incidence and Characteristics of Thyroid Dysfunction Following Interferon Therapy in Patients with Chronic Hepatitis C.

Cited by 18 publications

References 23 publications

Fatores Interferentes na Interpretação de Dosagens Laboratoriais no Diagnóstico de Hiper e Hipotireoidismo

Fatores Interferentes na Interpretação de Dosagens Laboratoriais no Diagnóstico de Hiper e Hipotireoidismo

Thyroid Function Testing

Atypical subacute thyroiditis and functional thyroid adenoma: Case report

Contact Info

Product

Resources

About