Incidence and Clinical Features of Autoimmune Hepatitis in the Province of Santa Fe (Argentina)

Costaguta, Alejandro; Gonzalez, Andrea F.; Pochettino, Sandra; Trotta, Liliana; Vicentín, Rosalía; Wagener, Marta

doi:10.1097/mpg.0000000000002122

Cited by 9 publications

(22 citation statements)

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“…A total of 17 studies reporting the incidence of AIH and the study characteristics are shown in Table 1, with 11 from Europe, 6,7,9,11,12,[19][20][21][22][23][24] three from Asia, 5,8,25 and three from America. [26][27][28] Sixteen studies reporting AIH prevalence rates were included, with nine from Europe, 6,7,9,11,12,20,21,23,24 two from America, 4,29 and five from Asia. 3,5,8,10,30 The characteristics of these studies are summarized in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies were considered as good quality, 11 as moderate quality, and three as poor quality. Among the 11 studies with moderate quality, seven studies were attributed to insufficient case-finding strategies, such as including only a single hospital data 3,25 or only outpatients, 22 or only children, [27][28][29] while the other four studies were due to the imperfect case-ascertainment process performed by other diagnostic criteria. 5,7,12,26 Three studies were regarded as poor quality because the case-ascertainment process was not reported.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 17 studies reporting the incidence of AIH and the study characteristics are shown in Table , with 11 from Europe, three from Asia, and three from America . Sixteen studies reporting AIH prevalence rates were included, with nine from Europe, two from America, and five from Asia .…”

Section: Resultsmentioning

confidence: 99%

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Systematic review and meta‐analysis on the incidence and prevalence of autoimmune hepatitis in Asian, European, and American population

Zeng

et al. 2019

J of Gastro and Hepatol

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Background and Aim Reported incidence and prevalence rates of autoimmune hepatitis (AIH) have been sparse and heterogeneous. The aim of this meta‐analysis was to estimate the worldwide incidence and prevalence rates of AIH and reveal population difference. Methods Published articles on the epidemiology of AIH in PubMed, Embase, and Cochrane Library were systematically searched from inception to April 28, 2019. Two investigators independently reviewed these literatures and evaluated their quality. A random‐effects model was used to pool the overall incidence and prevalence rates. The impact of population difference, gender, age, study period, study quality, diagnostic criteria, and study design was further analyzed with subgroup analysis and meta‐regression. Results A total of 22 studies were included in the meta‐analysis. The pooled worldwide annual incidence and prevalence of AIH were 1.37 (95% confidence interval [CI]: 0.95–1.80) and 17.44 (95% CI: 12.01–22.87) per 100 000 persons, respectively. Subgroup analysis showed that the pooled annual incidence for Asian, European, and American population was 1.31 (95% CI: 0.42–2.20), 1.37 (95% CI: 1.10–1.64), and 1.00 (95% CI: 0.44–1.56) per 100 000 persons, respectively; the pooled prevalence for Asian, European, and American population was 12.99 (95% CI: 2.05–23.92), 19.44 (95% CI: 15.63–23.24), and 22.80 (95% CI: −13.48 to 59.07) per 100 000 persons, respectively. In addition, higher incidence and prevalence rates were observed in women than men, and a higher prevalence rate was observed in elderly than young people. Conclusions Autoimmune hepatitis is a rare disease, with a similar incidence worldwide and a higher prevalence in European and American than in Asian population.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Systematic review and meta‐analysis on the incidence and prevalence of autoimmune hepatitis in Asian, European, and American population

Zeng

et al. 2019

J of Gastro and Hepatol

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“…The main clinical features are described in Tables and : differences of AIH and ASC prevalence, serological markers, response to classical treatment with predniso(lo)ne and azathioprine (Aza), and use of alternative therapy . Anti‐SLA/LP antibodies are rarely present in pediatric patients.…”

Section: Special Features Of Aih In South Americamentioning

confidence: 99%

Particularities of Autoimmune Hepatitis in Latin America

Porta

Cançado

2020

Clin. Liver Dis.

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“…Results. A total of 40 patients were included, 57.5% were female, with a median age of 10.5 years (IQR [4][5][6][7][8][9][10][11][12][13]. The 62.5% presented with acute hepatitis, 20% had liver failure, a 27.5% with cirrhosis at diagnosis; 75% presented compatible liver biopsy, and 82.5% were classified as type 1 autoimmune hepatitis.…”

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confidence: 99%

Perfil clínico de pacientes pediátricos con diagnóstico de hepatitis autoinmune en un centro de alta complejidad del suroccidente colombiano

Aristizábal-Henao¹,

Torres‐Canchala²,

Manzi³

et al. 2021

Acta gastroenterol. latinoam.

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Introduction. Autoimmune hepatitis is a progressive inflammatory liver disease that is rare in children, characterized by inflammation in liver histology, the presence of autoantibodies and high levels of immunoglobulin G. There are few data in children and in some studies performed in Latin America, but limited in Colombia. The aim of this study is to describe the demographic, clinical, paraclinical and therapeutic data as well as, the outcome of paediatric patients diagnosed with autoimmune hepatitis in a tertiary care centre in south-western Colombia. Methods. This is a descriptive study of a retrospective cohort of paediatric patients (≤ 18 years) with a diagnosis of autoimmune hepatitis, attended in a third-level hospital in Colombia between 2011 and 2019. Statistical analyses were performed using the program Stata 14.0. Results. A total of 40 patients were included, 57.5% were female, with a median age of 10.5 years (IQR 4-13). The 62.5% presented with acute hepatitis, 20% had liver failure, a 27.5% with cirrhosis at diagnosis; 75% presented compatible liver biopsy, and 82.5% were classified as type 1 autoimmune hepatitis. All patients received a steroid plus immunomodulator; presenting biochemical remission in 75% relapse in the 22.5%. Four of the patients required liver transplantation. Conclusions. Autoimmune hepatitis is an infrequent entity, although not negligible, in children in our environment. A higher prevalence of type I autoimmune hepatitis was found. Most patients were female and presented with symptoms of acute hepatitis at the initial diagnosis. The characteristics and clinical responses, in this cohort, are similar to those described in different series in the world population.

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Incidence and Clinical Features of Autoimmune Hepatitis in the Province of Santa Fe (Argentina)

Abstract: AIH has an estimated incidence of 0.56/100,000 per year in children from the province of Santa Fe (Argentina). Overall survival rate was 95%. A subgroup of patients diagnosed as AIH develops predominant biliary disease and should be better classified as autoimmune sclerosing cholangitis.

Cited by 9 publications

References 20 publications

Systematic review and meta‐analysis on the incidence and prevalence of autoimmune hepatitis in Asian, European, and American population

Systematic review and meta‐analysis on the incidence and prevalence of autoimmune hepatitis in Asian, European, and American population

Particularities of Autoimmune Hepatitis in Latin America

Perfil clínico de pacientes pediátricos con diagnóstico de hepatitis autoinmune en un centro de alta complejidad del suroccidente colombiano

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