Incidence and clinical picture of sarcoidosis in a circumscribed geographical area

Poukkula, Anneli; Huhti, E; Lilja, M; Saloheimo, M

doi:10.1016/0007-0971(86)90034-3

Cited by 28 publications

(11 citation statements)

References 13 publications

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“…3, 4, 12–19 The annual incidence was reported to be as low as 0.73 per 100,000 in Japanese males 12 to as high as 71 per 100,000 in African-American females (4). Our results are comparable with other studies with predominant Caucasian populations.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiology of Sarcoidosis 1946-2013

Ungprasert

Carmona

Utz

et al. 2016

Mayo Clinic Proceedings

241

140

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Objectives To characterize the epidemiology of sarcoidosis from 1946 to 2013. Patients and Methods An inception cohort of patients with incident sarcoidosis in 1976–2013 in Olmsted County, Minnesota was identified based on comprehensive individual medical record review. Inclusion required physician diagnosis supported by histopathological confirmation, radiologic features of intrathoracic sarcoidosis and compatible clinical presentation. Data were collected on demographic characteristics, clinical presentation, laboratory investigations and mortality. The data were augmented with a previously identified cohort of Olmsted County, Minnesota residents diagnosed with sarcoidosis in 1946–1975. Incidence rates were age and sex adjusted to the US white 2010 population. Results A total of 448 incident cases of sarcoidosis were identified (mean age 44.2 years and 52% female). The annual incidence of sarcoidosis was 10.0 per 100,000 population. The incidence of sarcoidosis increased among females from 1950–1960, but otherwise there were no significant calendar year trends. However, the peak age at incidence among females shifted from 40–59 years in 1950 to 50–69 years in 2010. Similarly, the peak age at incidence for males shifted from 30–49 years in 1950 to 40–59 years in 2010. 97% of cases had intrathoracic involvement but only 43% of patients had respiratory symptoms. The overall mortality of patients with sarcoidosis was not different from general population (standardized mortality ratio: 0.90; 95% CI, 0.74–1.08). Conclusions Sarcoidosis occurred in about 10 persons per 100,000 per year. Most of the patients had intra-thoracic involvement, although less than half had respiratory symptoms. Overall mortality was not different from general population.

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Section: Discussionmentioning

confidence: 99%

“…Our results are comparable with other studies with predominant Caucasian populations. 3, 14, 15, 17–19 …”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Sarcoidosis 1946-2013

Ungprasert

Carmona

Utz

et al. 2016

Mayo Clinic Proceedings

241

140

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“…Most patients were female (89%). Sarcoidosis was diagnosed more often in the first half of the year in Finland, especially if patients had symptoms [6], and also in Japan, where a significant increase in cases presented in June and July [7].…”

Section: Discussionmentioning

confidence: 99%

Seasonal clustering of sarcoidosis presenting with erythema nodosum

Wilsher

1998

Eur Respir J

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Seasonal clustering of sarcoidosis presenting with erythema nodosum (EN) has previously been reported only in the northern hemisphere. Of 59 patients presenting to a single centre in New Zealand with a new diagnosis of sarcoidosis, 21 had EN and three more had acute arthralgia without EN. These patients were compared with the rest of the cohort. The patients with EN or arthralgia alone presented exclusively between April and December, with peak clustering in the spring months of August, September and October (p<0.001, Fisher's exact test). This cohort was more likely to have a stage I chest radiograph and to be female (p<0.05), but there were no other differences between the groups. This is the first report of seasonal clustering in the southern hemisphere suggesting a common environmental trigger in the aetiology of sarcoidosis.

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“…Genetic tendency, environmental factors and immunologic abnormalities are considered in the pathogenesis of the disease, but the exact cause and the disease pathogenesis have not been fully understood. Numerous studies which concerned the aetiology of sarcoidosis have reported a seasonal variation of sarcoidosis and pointed out an unidentified environmental factor(s) (3)(4)(5)(6)(7)(8)(9)(10)(11). However, these studies and others have never studied the interaction among sarcoidosis seasonality and both age and gender.…”

Section: Introductionmentioning

confidence: 99%

Seasonal variation of the onset of presentations in stage 1 sarcoidosis

Demirkok

Başaranoğlu

Akbilgiç

2006

International Journal of Clinical Practice

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Sarcoidosis is a chronic disease with an unknown aetiology. Our aim was to evaluate the pattern of seasonality of stage 1 sarcoidosis subjects who had symptoms by all cases, by age and by both genders. In this study, we used Roger's test for cyclic variation to prove that this seasonal variation was more than chance. Four hundred ninety-two consecutive patients with sarcoidosis who presented different clinical symptoms were included in this retrospective cohort study. According to the chest X-ray examinations, 185 patients had stage 1, while 307 patients in control group had stage 0, 2, 3 and 4 sarcoidosis. The demographic features, presenting clinical features, course of the disease, initial diagnostic methods and both the month and the age at the initial diagnosis for each patient were analysed on chart reviews. Roger's test for cyclic variation was used to determine the significance of any seasonal variation of incidence. Otherwise, t-test was used. The distribution of cumulative monthly presentations for patients with stage 1 peaked in April (108% above the average) and was lowest in October, November and December (48% below the average) (p < 0.001). Seasonality of the control group peaked in May (84% above the average) and was lowest in August (69% below the average) (p < 0.001). The seasonal pattern of subjects within both groups was influenced by some age groups and by both genders (p < 0.05). Some differences in the amplitude of the seasonal variation by age and by both genders increase the possibility of interactions among age, gender and the disease. Further well-designed and prospective studies are required to better understand the importance of our findings and the pathogenesis of the disease.

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Incidence and clinical picture of sarcoidosis in a circumscribed geographical area

Cited by 28 publications

References 13 publications

Epidemiology of Sarcoidosis 1946-2013

Epidemiology of Sarcoidosis 1946-2013

Seasonal clustering of sarcoidosis presenting with erythema nodosum

Seasonal variation of the onset of presentations in stage 1 sarcoidosis

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