Incidence and distribution of congenital malformations clinically detected at birth: a prospective study at tertiary care hospital

Gandhi, Mohammad K.; Chaudhari, Upendra Rameshbhai; Thakor, Nilesh

doi:10.18203/2320-6012.ijrms20160797

Cited by 5 publications

(2 citation statements)

References 4 publications

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“…Prevalence of congenital anomalies was 0.9% in this study. The worldwide rate of congenital malformations ranges between 2% -3% of all births, and differs between countries according to implementation of powerful routine ultrasound screening programs and detection rates of different anomalies [10]. Our results were a partly comparable with those of Taboo, et al who evaluated the predominance of congenital anomalies and the associated risk factors in Iraq.…”

Section: Discussionsupporting

confidence: 86%

Predominance of fetal malformations among pregnant women: A multi-centric observational study

Sayed¹,

Khalifa²,

Shehata³

et al. 2021

Clin J Obstet Gynecol

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Objective: To observe the predominance of fetal anomalies in pregnant women in a multi-centric setting. Methods: This prospective observational study included 20225 pregnant women who came for antenatal care in University Hospital and fetal medicine units from 2016 to 2019. Fetal anatomical scanning was done for all participants. Results: One hundred eighty-three cases had fetal congenital anomalies, yielding a prevalence of around 0.9%. Third of cases had positive consanguinity, this increased in cases of skeletal and thoracic anomalies. The presence of past history of anomalies was evident in 8.2% mostly with skeletal and heart anomalies. History of drug intake was only verified in 1.6% of cases. Sixty-three women out of 183 (34.4%) were diagnosed to have anomalies in fetal nervous system. Conclusion: Prenatal diagnosis are recommended for early detection of congenital anomalies and counselling.

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Section: Discussionsupporting

confidence: 86%

Predominance of fetal malformations among pregnant women: A multi-centric observational study

Sayed¹,

Khalifa²,

Shehata³

et al. 2021

Clin J Obstet Gynecol

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“…7,8 Vyas et.al from Kota and Gandhi et.al from Surat both have reported much lower incidence of congenital anomalies at birth i.e 1.23%. 9,10 In our study the maximum number of congenital anomalies was from the musculo skeletal system followed by the central nervous system. Tenali et.al and Bhat et.al have also reported musculoskeletal congenital anomalies as the commonest.…”

Section: Discussionmentioning

confidence: 73%

Spectrum of congenital malformations at birth among neonates in a private medical college in South Rajasthan

Bhatia

2019

Int J Contemp Pediatr

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Background: Congenital anomalies contribute to about 12% neonatal deaths annually .Neonates with multiple congenital malformations pose a very difficult management problem for the treating physician. This study was done to know the incidence, pattern of congenital anomalies and to study various maternal risk factors leading to congenital anomalies which may help us in devising strategies for better patient counseling and management.Methods: Prospective cross sectional study carried out from 1st Jan 2014 to 31st December 2018 in a private medical college in India. Neonates (both live and still born) delivered in our hospital during this period formed the part of study group. All congenital anomalies present were documented and classified according to system involoved.Results: Total number of neonates with congenital anomalies were 90, out of which 73 were live births and 17 were still births. The overall incidence of congenital anomalies was 2.375%. The commonest system affected was musculoskeletal system (27.7%) followed by CNS (24.4%). Among the maternal risk factors studied, increased maternal age, consanguineous marriage, maternal gestational diabetes mellitus were all significant risk factors associated with congenital anomalies.Conclusion: Congenital anomalies are a global health problem. In our study we have documented that multiparity, consanguinity, diabetes mellitus, Pregnancy induced Hypertension (PIH), maternal anemia, maternal malnutrition to be major contributing factors for congenital anomalies. Present study highlighted that musculoskeletal and CNS systems to be the most commonly affected by congenital malformations. Antenatal scans remain an important diagnostic tool in screening for congenital anomalies. A good clinical examination at birth could help in early detection of life threatening congenital malformation thereby improving chances of his or her survival.

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Outcome of Nonurinary Surgical Malformations Predicted by Fetal Abdominal Signs on Prenatal Ultrasound

Gupta

Ezung

Kumar

et al. 2021

Journal of Clinical Neonatology

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Aim: The aim of our study was to study the outcome of “nonurinary” surgical malformations predicted by fetal abdominal signs on prenatal ultrasound (US). Methods: This prospective observational study was done over a 3-year period. Results: Out of 66 cases, 15 different malformations were detected. The accuracy of prenatal US was 83.3%. There were four still births, two medical termination of pregnancy, and sixty live births (91%). Postnatal surgery was necessary in 35 neonates (62.5%) with postoperative survival of 71.4%. Sixteen neonates (26.7%), 7 with normal postnatal US and 9 asymptomatic lesions, were managed conservatively. Overall 1-year survival rate of fetuses was 62.1%. The most common malformations confirmed postnatally were duodenal atresia (n = 14, 23.3%), followed by gastroschisis (n = 9; 15%), esophageal atresia (n = 8; 13.3%), meconium peritonitis (n = 4; 6.7%), and ovarian cyst (n = 4; 6.7%). Prematurity (n = 34; 56.7%) and low birth weight (n = 44; 66.7%) had no significant effect on survival due to in utero transfer to tertiary care. Salient factors adversely affecting the survival were: (1) type of anomaly-omphalocele major and fetal ascites (FA) had no survivors, (2) postoperative complications, and (3) associated cardiac anomalies. It was also notable that, among fetal signs of meconium peritonitis, isolated intra-abdominal calcification had a good prognosis with 75% survival, whereas FA had no survivors. Conclusions: Results of this study will be helpful in realistic prognostication and postnatal management of these anomalies in the appropriate hospital setting.

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Incidence and distribution of congenital malformations clinically detected at birth: a prospective study at tertiary care hospital

Cited by 5 publications

References 4 publications

Predominance of fetal malformations among pregnant women: A multi-centric observational study

Predominance of fetal malformations among pregnant women: A multi-centric observational study

Spectrum of congenital malformations at birth among neonates in a private medical college in South Rajasthan

Outcome of Nonurinary Surgical Malformations Predicted by Fetal Abdominal Signs on Prenatal Ultrasound

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