Incidence and familial clustering of infantile haemangiomas: a multicentre study

Abstract

Background The exact incidence of infantile haemangiomas (IH) in the Chinese population is still unknown. A positive family history of IH was considered as a risk factor for the development of IH.Objectives This study aims to investigate the incidence of IH in the Chinese population and the mechanism of family history increases the risk for IH development.Methods A total of 2489 women and their newborns were enrolled in the prospective study. All newborns were followed up for 12 months to determine whether they developed IH. In addition, 213 IH probands and their 174 siblings were enrolled in the study. The incidence of IH in siblings of the IH probands was investigated. Information regarding risk factors for IH and demographic data were collected on all children.Results Of the 2572 newborns, 58 IH were identified in 56 (2.2%) newborns. The majority of IH were located on the trunk (46.6%). Siblings of the IH probands were at increased risk for the development of IH (P = 0.024, relative risk 2.451), and the occurrence of prenatal risk factors for IH(P = 0.003) compared with the general population.Conclusions Our study showed that the incidence of IH is 2.2% in the Chinese population. Siblings of the individuals with IH were at increased risk for the development of IH may be related to the family clustering of prenatal risk factors for IH. Further exploration of the mechanisms and common features of these prenatal risk factors may help to disclose the origin and pathogenesis of IH.

The prevalence, complications, and risk factors for infantile hemangioma: a systematic review and meta‐analysis

“…Figure 1 lists the screening process and reasons for exclusion. 27 studies 7–9,27–50 investigated prevalence, mainly in America, Germany, Canada, Israel, Japan, Australia, Netherlands, Denmark, China, Mali, and Brazil. 27 studies 7,12,28,35–37,44,45,47,50–67 reported the distribution of IH lesions, and 14 studies 7,12,35,50–52,55,57,59,61,63,64,68,69 surveyed the occurrence of complications.…”

“…Moreover, we observed vaginal bleeding, preeclampsia, placental abnormalities, placenta previa, premature rupture of membranes, anemia, previous miscarriage, periconceptional use of drugs, maternal b-blocker, in vitro fertilization, amniocentesis, chorionic villus sampling dependent associations for the occurrence of IH. 7,16,31,40,44,46,55,63,70,72 In addition, Smith 8…”

“…27 studies [7][8][9] investigated prevalence, mainly in America, Germany, Canada, Israel, Japan, Australia, Netherlands, Denmark, China, Mali, and Brazil. 27 studies 7,12,28,[35][36][37]44,45,47,[50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67] reported the distribution of IH lesions, and 14 studies 7,12,35,[50][51][52]55,57,59,61,63,64,68,69 surveyed the occurrence of complications. Specifically, 28 studies 7,9,16,[30][31][32]…”

“…27 studies 7,12,28,[35][36][37]44,45,47,[50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67] reported the distribution of IH lesions, and 14 studies 7,12,35,[50][51][52]55,57,59,61,63,64,68,69 surveyed the occurrence of complications. Specifically, 28 studies 7,9,16,[30][31][32][33][34]36,40,41,…”

Management of infantile hemangiomas: Recent advances

“…Generally, IHs often occur in sporadic cases from various regions and racial/ethnic groups, although a few familial aggregations that are considered to be genetically related may exist ( 5 ). Recently, a multicenter study found an increased risk of IHs in siblings of patients with IHs, which is considered to be due to the familial clustering of prenatal risk factors ( 6 ).…”