Incidence and morbidity of hospital‐presenting corneal infiltrative events associated with contact lens wear

Efron, Nathan; Morgan, Philip B.; Hill, Elizabeth A.; Raynor, Mathew K.; Tullo, Andrew B.

doi:10.1111/j.1444-0938.2005.tb06701.x

Cited by 47 publications

(58 citation statements)

References 31 publications

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“…Previous studies have shown that overnight contact lens wear and the use of extended wear contact lenses are associated with an increased risk of microbial keratitis [4] and corneal infiltrative events [5]. Almost half (49 %) of the patients in our study had some risk factor for development of CLRCs.…”

Section: Discussionmentioning

confidence: 92%

“…Although contact lenses are considered safe, it is not rare for patients to develop contact lens-related problems particularly when contact lens care is not meticulous. It has been estimated that about 6-21 % of contact lens wearers develop a contact lens-related complication each year [3,4]. The severity of these problems can range from mild corneal epitheliopathy to vision-threatening microbial keratitis.…”

Section: Introductionmentioning

confidence: 99%

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First contact diagnosis and management of contact lens-related complications

et al. 2012

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To describe the spectrum of contact lens-related problems in cases presenting to a tertiary referral eye hospital. A retrospective case record analysis of 111 eyes of 97 consecutive patients was undertaken over a period of five months at the Royal Victorian Eye and Ear Hospital, Melbourne, Australia. Contact lens-related complications (CLRC) were classified into microbial keratitis, sterile corneal infiltrates, corneal epitheliopathy and contact lens-related red eye (CLARE). Main parameters examined were nature of the first contact, clinical diagnosis, and management pattern. Forty-two percent of the initial presentations were to health care practitioners (HCPs) other than ophthalmologists. Mean duration from the onset of symptoms to presentation was 6.3 ± 10.9 days. Forty-nine percent (n = 54) of patients had an associated risk factor, most commonly overnight use of contact lenses (n = 14, 13 %). Most common diagnosis at presentation was corneal epitheliopathy (68 %) followed by sterile infiltrates (10 %), CLARE (8 %) and microbial keratitis (6 %). No significant differences were found in the pattern of treatment modalities administered by ophthalmologists and other HCPs. HCPs other than ophthalmologists are the first contact for contact lens-related problems in a significant proportion of patients. These HCPs manage the majority of CLRC by direct treatment or immediate referral.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

First contact diagnosis and management of contact lens-related complications

et al. 2012

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“…Many authors reported that asymptomatic lens wear for extended periods did increase ocular microbiota (Larkin et al, 1991;Hart et al, 1993) and others reported that asymptomatic lens worn for extended periods did not increase normal ocular microbiota (Gopinathan et al, 1997;Willcox et al, 1997). However, Efron et al (2005) suggested that ocular diseases of contact lens wearer could be as a result of noncompliance or omission of surfactant cleaning rub and rinse steps, the use of disinfecting solution of marginal efficacy and lenses that attract and rapidly deposit protein. Thus, the lens care regimen is an important factor for consideration on subjects that showed no growth among the daily and extended contact lenses wearers.…”

Section: Discussionmentioning

confidence: 99%

Bacteria isolated from contact and non contact lens and antibiotic susceptibility patterns of isolated Pseudomonas aeruginosa

Al-Zahrani¹

2012

Afr. J. Microbiol. Res.

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The aim of this study was to investigate the prevalence and type of microbial contamination, associated with contact lenses and lens care accessories used by a group of contact lens wearers. Results show that a total of 178 strains were isolated, including, 100 Gram positive and 78 Gram negative bacteria. Staphylococcus epidermidis and Pseudomonas aeruginosa were the most common microorganisms isolated (25.281 and 13.483% respectively. 24 P. aeruginosa were isolated from lenses and eyes of contact lens and non-contact lens wearers. All isolates were susceptible to the tested aminoglycosides and fluoroquinolones. Aminoglycosides and fluoroquinolones (ciprofloxacin) were more efficient than β-lactams. 91.67% of the strains had intermediate-resistant to cefotaximee; 4.17% were resistant and 4.17% were sensitive to Cefotaximee. 95.83% of the strains were sensitive, while 4.17% were resistant to Imipenem. 20.83 and 12.5% of P. aeruginosa strains were resistant and sensitive to Ceftriaxone respectively, while 66.67% were moderately-resistant to ceftriaxone of the β-lactam class. All isolates were sensitive to the other tested β-lactam.

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“…The details of this work -collectively referred to as 'The Manchester Keratitis Study' -have been published previously [4][5][6][7][8][9][10] and will be referred to extensively throughout this chapter. The design of this experiment is represented schematically in Figure 24.5.…”

Section: The Manchester Keratitis Studymentioning

confidence: 99%