Incidence and mortality of cervical cancer in China, 2013

Song, Bingbing; Ding, Chao; Chen, Wangyang; Sun, Hongwei; Maoxiang, Zhang; Chen, Wanqing

doi:10.21147/j.issn.1000-9604.2017.06.01

Cited by 59 publications

(45 citation statements)

References 25 publications

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“…The incidence of invasive CC was 8.9 per 100,000 women between 1998 and 2003 [3]. A total of 100,700 new cases were diagnosed as CC in China, which accounted for 6.16% of female malignant tumors in 2013 [4]. From 2015 to 2030, the estimated mortality rate of CC will increase by approximately 22% in the whole world [5].…”

Section: Introductionmentioning

confidence: 99%

Identification of Circulating MicroRNAs as a Promising Diagnostic Biomarker for Cervical Intraepithelial Neoplasia and Early Cancer: A Meta‐Analysis

Jiang

Hu²,

Zuo

et al. 2020

BioMed Research International

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Background. Cervical cancer (CC) is one of the most common female malignant tumors. And cervical intraepithelial neoplasia (CIN) is the precancerous lesion of CC, which can progress to invasive CC. MicroRNAs (miRNAs) have been found to be potential diagnostic biomarkers for CIN or CC. However, recently, the lack of sufficient studies about the diagnostic value of miRNAs for CIN made it challenging to separately investigate the diagnostic efficacy of miRNAs for CIN. Likewise, the conclusions among those studies were discordant. Therefore, we conducted this meta-analysis, aimed at evaluating the diagnostic efficacy of miRNAs for CIN and CC patients. Methods. Literature search was performed in PubMed, Embase, and Web of Science databases. Pooled sensitivity, specificity, and other diagnostic parameters were calculated through Stata 14.0 software. Furthermore, subgroup analyses and metaregression analysis were conducted to explore the main sources of heterogeneity. Results. Ten articles covering 50 studies were eligible, which included 5,908 patients and 4,819 healthy individuals. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were 0.81 (95% CI, 0.77-0.85), 0.86 (95% CI, 0.83-0.89), 5.9 (95% CI, 4.5-7.7), 0.22 (95% CI, 0.17-0.28), 27 (95% CI, 17-44), and 0.91 (95% CI, 0.88-0.93), respectively. Additionally, the ethnicity and internal reference were the main sources of heterogeneity. Conclusions. Circulating miRNAs can be a promising noninvasive diagnostic biomarker for CIN and early CC, especially miR-9 and miR-205, which need to be verified by large-scale studies.

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Section: Introductionmentioning

confidence: 99%

Identification of Circulating MicroRNAs as a Promising Diagnostic Biomarker for Cervical Intraepithelial Neoplasia and Early Cancer: A Meta‐Analysis

Jiang

Hu²,

Zuo

et al. 2020

BioMed Research International

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“…The analysis of CC mortality, aiming to provide helpful information for the development of cancer research and intervention programs, has been a subject of debate in recent decades (Song et al, 2017;Vicus, 2014). This study provides results similar to those by the Ministry of Health: the North region (Inca et al, 2018) has the highest rates when standardized by the world population, followed by the Northeast (5.81/100 thousand) (Brasil, 2016) and the Midwest (18.32/100 thousand) regions (Inca et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…In other countries, such as China, CC incidence increased in , compared to 2003to 2007(Song et al, 2017. In contrast, the CC mortality rate decreased by 0.9 in Poland (Leśniczak et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Trends in Cervical Cancer Mortality in Brazilian Women who are Screened and Not Screened

Vargas

Agnolo

Melo

et al. 2020

Asian Pac J Cancer Prev

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Objective: This study aimed to analyze the trend in cervical cancer (ICD C53) mortality in Brazilian regions in women who are who are screened and not screened from 1996 to 2015. Methods: An epidemiological study, of time series of mortality from cervical cancer performed in 90,856 women under 24 years old (343 women), between 25 and 64 years old (32,703 women), and over 65 years old (10,909 women). The data from this research were collected from the DATASUS, from the SIM Health Surveillance Secretariat files, captured through TABNET selecting the resident population by gender and age group and ICD 10 C53 from 1996 to 2015. Results: Among women, 43.8% were white, and 76% had less than eight years of formal education. Polynomial regression showed an increasing trend in cervical cancer mortality in Brazil for women aged 15 -24 years (p=0.01). Between 25 -64 and 65 years or older it remained constant, but high (p=0.07; 0.99). The Northeast region pointed a growing trend in women aged 15 to 24 (p=0.01), 25 to 64 years (p=0.01) and 65 or older (p=0.001). The Northeast presented the highest average growth per year. In the Southeast, South and Midwest regions, decreasing trends were observed despite the high rates. The Joinpoint regression showed a 95% confidence interval, and that mortality from cervical cancer in the North region increased throughout the period analyzed. an increasing trend was observed from 1996 to 1998, whereas in the Midwest region, the trend remained stable throughout the period analyzed. The Federal District presented an upward trend from 1996 to 2015. In Brazil, an upward trend was observed throughout the whole period analyzed. Conclusions: Cervical cancer mortality in younger women is becoming more predominant, in addition to the high rate observed for women aged 65 or older.

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“…In 2018, there were an estimated 570,000 new cases of CC in the world and 311,000 deaths, with 85% of the new cases being in developing countries [2]. In China, the incidence of CC has been increasing in recent years, but the mortality has been decreasing [3][4][5], probably because of the implementation of screening and early treatment of cervical lesions [6].…”

Section: Introductionmentioning

confidence: 99%

Significance of the Viral Load of High-risk Hpv in the Diagnosis and Prediction of Cervical Lesions: A Retrospective Study

Liu

Pan

et al. 2020

Preprint

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Background: The significance of HPV viral load in the detection of cervical lesions is still controversial. This study analyzed the correlation between the high-risk (HR)-HPV viral load and different cervical lesion degrees.Methods: This was a retrospective study of the patients who first visited the hospital between January 2015 and June 2018. Patients with positive HR-HPV were screening for cervical cancer. The HR-HPV DNA load was measured by the second generation hybrid capture (HC2) technology. The patients grouped as normal, CIN I, CIN II, CIN III, and cervical cancer. Multivariable logistic regression was performed to explore the association between HR-HPV DNA load and cervical lesions.Results: Finally, 265 patients were grouped as normal (n=125), CIN I (n=51), CIN II (n=23), CIN III (n=46), and cervical cancer (n=20). Among them, 139 (52.5%) had a low viral load, 90 (34.0) had a moderate viral load, and 36 (13.4%) had a high viral load. Taking the normal control group as a reference, a high viral load was an independent factor for CIN I (CIN I: OR=3.959, 95%CI: 1.300-12.059, P=0.015) CIN II (OR=6.211, 95%CI: 1.641-23.513, P=0.007), CIN III (OR=7.002, 95%CI: 2.308-21.244, P=0.001), and cervical cancer (OR=9.439, 95%CI: 2.394-37.22, P=0.001).Conclusion: Cervical lesions are closely related to HR-HPV infection. Higher HR-HPV viral load in cervical lesions was associated with a higher risk of high-grade cervical lesions.

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Incidence and mortality of cervical cancer in China, 2013

Cited by 59 publications

References 25 publications

Identification of Circulating MicroRNAs as a Promising Diagnostic Biomarker for Cervical Intraepithelial Neoplasia and Early Cancer: A Meta‐Analysis

Identification of Circulating MicroRNAs as a Promising Diagnostic Biomarker for Cervical Intraepithelial Neoplasia and Early Cancer: A Meta‐Analysis

Trends in Cervical Cancer Mortality in Brazilian Women who are Screened and Not Screened

Significance of the Viral Load of High-risk Hpv in the Diagnosis and Prediction of Cervical Lesions: A Retrospective Study

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