Incidence and mortality rates of <scp>Guillain‐Barré</scp> syndrome in Serbia

Stojanov, Aleksandar; Berisavac, Ivana; Božović, Ivo; Arsenijević, Miloš; Lukic-Rajic, Sonja; Petrovic, M.; Stojiljkovic-Tamas, Olivera; Jovin, Zita; Djordjević, Gordana; Jovanović, Dejana; Stojanović, Miroslav; Martić, Vesna; Basta, Ivana; Perić, Stojan

doi:10.1111/jns.12412

Cited by 15 publications

(10 citation statements)

References 47 publications

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“… 18 , 36 The 1-year mortality rate was 5.0% in the present study, which is similar to previous results in southeast England (8%), Asian countries (6%), Taiwan (4%), and the Netherlands (3.9%), 7 32 35 37 and better than the 6-month mortality rate of 9.7% found in Serbia. 38 Our study also revealed the mortality rate over a very long mean observation period of 9.0 years after the diagnosis. Finally, the SMR of patients with GBS had decreased year by year after the diagnosis, but remained significantly high until 5 years after the diagnosis in the Korean population.…”

Section: Discussionsupporting

confidence: 58%

Incidence, Disability, and Mortality in Patients With Guillain-Barré Syndrome in Korea: A Nationwide Population-Based Study

Lee

Hong

et al. 2022

J Clin Neurol

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Background and Purpose This study aimed to identify the epidemiological features of Guillain-Barré syndrome (GBS) in the Korean population. Methods Patients with GBS were defined as those who were hospitalized with a primary diagnostic code of G61.0 on the Korean Classification of Disease in a department of neurology, rehabilitation medicine, or pediatrics. We evaluated the incidence and prevalence of GBS as well as physical disability, mortality, and cause of death in patients with GBS from 2002 to 2018 in the Korean population using the Korean National Health Insurance Service database. Results We identified 11,146 patients with GBS. The ratio of males to females was 1.48. The age-adjusted incidence rate per 100,000 persons increased steadily from 0.84 in 2002 to 1.68 in 2018, as did the age-adjusted prevalence rate per 100,000 persons, from 0.77 to 15.62. The incidence and prevalence of GBS increased with age, peaking at 70–79 years. Among 10,114 patients without physical disability at the time of GBS being diagnosed, 502 (5.0%) patients had moderate disability and 526 (5.2%) had severe disability by the end of the study period. A total of 1,221 (11.0%) patients with GBS died during the mean follow-up period of 17 years (2002–2019). There were 144 (1.3%) in-hospital deaths. Conclusions This was the first nationwide epidemiological study of patients with GBS covering the entire population including patients of all ages in the Republic of Korea. We have revealed the seasonality of admissions, disability, and long-term mortality rates in patients with GBS.

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Section: Discussionsupporting

confidence: 58%

Incidence, Disability, and Mortality in Patients With Guillain-Barré Syndrome in Korea: A Nationwide Population-Based Study

Lee

Hong

et al. 2022

J Clin Neurol

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“…The most frequent subtype of GBS in both our groups was AIDP. Unrelated to the preceding event, AIDP is the most common subtype of GBS present in about 69–90% of patients [ 22 ] and it is also the most common subtype among GBS patients in our country [ 26 ]. This clinical variant has also been reported as the most frequent subtype of GBS associated with COVID-19 [ 12 , 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

Is there a difference between GBS triggered by COVID-19 and those of other origins?

Radišić

Ždraljević

Perić

et al. 2022

Egypt J Neurol Psychiatry Neurosurg

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Background Since the outbreak of the coronavirus disease 2019 (COVID-19), an increasing number of Guillain–Barré syndrome (GBS) cases following the infection has been reported. The aim of our study was to detect patients with GBS treated in our hospital over a 1-year period and to compare the characteristics and outcomes of those triggered by COVID-19 with the rest of GBS patients. Our prospective study included 29 patients who were diagnosed with GBS from March 2020 to March 2021. Based on the preceding event, patients were stratified as post-COVID-19 and non-COVID-19. The GBS disability scale (GDS) was used to assess functional disability. Results We identified 10 (34.5%) patients with post-COVID-19 GBS and 19 (65.5%) patients with non-COVID-19 GBS. The median time from the preceding event to the symptoms onset was longer in post-COVID-19 than in non-COVID-19 GBS patients (p = 0.04). However, the time from the symptom onset to the nadir did not differ (p = 0.12). GDS at admission, as well as at nadir, did not differ between these two groups. The level of proteinorrachia was higher in post-COVID-19 GBS patients (p = 0.035). The most frequent subtype of GBS in both groups was acute inflammatory demyelinating polyneuropathy (AIDP). GDS score at discharge (p = 0.56) did not differ between two study groups. Conclusions There was no difference in clinical and electrophysiological features, disease course, and outcome in post-COVID-19 compared with non-COVID-19 GBS patients.

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“…Clinically, it is an acute bilateral, symmetrical, synchronous, ascending motor and/or sensory impairment. The risk of cardiovascular dysautonomic symptoms and the involvement of chest and bulbar muscles lead to a high mortality of the condition [ 16 ]. The ten deaths recorded in the study were due to APRN alone, resulting in a mortality of 21.3% of APRN cases.…”

Section: Discussionmentioning

confidence: 99%

Etiological profile of peripheral neuropathies in an academic hospital in southern Morocco

Poda

Klevor

Salym

et al. 2022

Egypt J Neurol Psychiatry Neurosurg

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Background Peripheral neuropathies constitute a common complaint in general and neurology practice, and are a source of handicap to patients. Epidemiological data in the Middle East and North Africa region as well as in the African continent are sparse. Nevertheless, regional etiological profiles are crucial in navigating the diagnostic maze of neuropathies. This study outlines the etiological profile of peripheral neuropathies in an academic hospital in southern Morocco. Results A total of 180 cases were recorded in a span of 8 years (22.5 cases per year). The mean age of patients was 42.35 years. Male gender was predominant (68.88%), with a sex ratio of 2.2. Motor symptoms were the most frequently reported (86.6%). The axonal form (40.56%) was the most frequently encountered electrophysiologic form. The most frequent etiologies in the study were diabetes (26.7%), acute polyradiculoneuropathy (26.1%) and amyotrophic lateral sclerosis (16.1%). Alcohol neuropathy was found in 2.2% of the cohort. No cause was found in 5% of cases. Outcome was mostly favorable under treatment, although 10 deaths due to acute polyradiculoneuropathy were recorded (mortality = 21.3%). Conclusions Knowledge of the etiological profile of peripheral neuropathies should guide clinicians to an early diagnosis and aid in an adapted management of patients.

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Incidence and mortality rates of Guillain‐Barré syndrome in Serbia

Cited by 15 publications

References 47 publications

Incidence, Disability, and Mortality in Patients With Guillain-Barré Syndrome in Korea: A Nationwide Population-Based Study

Incidence, Disability, and Mortality in Patients With Guillain-Barré Syndrome in Korea: A Nationwide Population-Based Study

Is there a difference between GBS triggered by COVID-19 and those of other origins?

Etiological profile of peripheral neuropathies in an academic hospital in southern Morocco

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