Incidence and Mortality Rates of Oral Cancer in California from 1995-2004

Saini, Reena R

doi:10.15406/jdhodt.2016.04.00096

Cited by 1 publication

(1 citation statement)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several risk factors for OSCC have been established, including smoking, alcohol intake, use of smokeless tobacco, and infection with human papillomavirus [ 1 ]. Despite advances in cancer care, oral cancer patients have a five-year mortality rate of about 50% in different stages of the disease [ 2 , 3 ]. Advances in early diagnosis and more personalized therapy to minimize morbidity are being investigated globally on oral cancer patients globally [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA Profiling in Circulating Exosomes in Oral Squamous Cell Carcinoma: A Systematic Review

Ramani,

Yuwanati

et al. 2023

Cureus

View full text Add to dashboard Cite

Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer with several risk factors. Exosomes are extracellular vesicles generated by the fusion of multivesicular structures with the cell membrane and play an important role as intercellular messengers. MicroRNA (miRNA) is a noncoding RNA and regulates post-transcriptional modification. The present systematic review aims to identify and correlate the possible association and role of circulating exosomes with OSCC. Using the search strategy, articles fulfilling the inclusion criteria, published between January 2012 to March 2022, were retrieved from online databases including PubMed, Scopus, Web of Science, and Cochrane Library. About 904 articles were found using an electronic database and a human search. After reviewing the titles and abstracts, 614 studies were eliminated, and duplicate articles were removed. Five studies were included in this systematic review. Circulating exosomal expression of miRNA27, miRNA 21, and miRNA 155 showed significant upregulation in OSCC patients. Circulating exosomes could be potential biomarkers to be used in the detection of patients with OSCC. More studies are warranted in this area to gain a better understanding of the pathophysiology of OSCC and the function of molecular markers from circulating exosomes. Understanding the role of molecular markers from circulating exosomes in pathogenesis will provide a better understanding of the development of the disease, necessitating more study in this area. According to this review, circulating exosomes might be a potential approach to the identification of OSCC.

show abstract