Incidence and mortality trend of cervical cancer in 11 cancer registries of China

Tao, Lei; Mao, Weimin; Liu, Tonghai; Li-qiong, Dai; Fang, Luo; Chen, Wanqing; Zhang, Siwei

doi:10.1007/s11670-011-0010-x

Cited by 23 publications

(25 citation statements)

References 12 publications

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“…Approximately 50% of all CC cases in the world were recorded in China and India (26). Nearly 181,500 people are diagnosed with CC each year in China, while >30,000 women succumbed to CC (27). In Europe, ~38,000 CC cases are diagnosed each year, and >2/3 of those would be expected to be cured and survive (28).…”

Section: Discussionmentioning

confidence: 99%

E6/E7 proteins are potential markers for the screening and diagnosis of cervical pre‑cancerous lesions and cervical cancer in a Chinese population

Shi

Líu

et al. 2017

Oncol Lett

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Abstract. The present prospective study aimed to evaluate the effects of E6/E7 protein detection by western blotting on cervical cancer (CC) early screening compared with detection by Hybrid Capture 2 (HC2) test and ThinPrep cytological test (TCT) in a Chinese population. A total of 450 cases of cervical intraepithelial neoplasia (CIN) suspected samples (positive in ≥1 indicator of TCT and HC2 test) were recruited from women who were treated at the International Peace Maternity and Child Health Hospital (Shanghai, China) from March 2014 to February 2015. Each sample was analyzed by cytological test. In addition, human papillomavirus (HPV) DNA examination by Hybrid Capture Tube test and E6/E7 protein expression detection by western blotting were performed in all samples, as well as histologic diagnosis to determine the stage of CIN. The results revealed that, for the diagnosis of CIN2 + , although the sensitivity of E6/E7 protein detection was lower than that of HC2 test (71.3 vs. 96.6%, respectively), the specificity was markedly improved (67.6 vs. 5.9%, respectively). Compared with that of TCT, the sensitivity of E6/E7 protein detection was much higher (36.2 vs. 71.3%, respectively), but the specificity was lower (88.2 vs. 67.6%, respectively). In the present study, HPV E6/E7 protein expression was evaluated as a potential new biomarker for CC, with satisfactory diagnostic values for HPV types 16 and 18. The relative diagnostic value may be further improved by combination of E6/E7 messenger RNA detection.

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Section: Discussionmentioning

confidence: 99%

E6/E7 proteins are potential markers for the screening and diagnosis of cervical pre‑cancerous lesions and cervical cancer in a Chinese population

Shi

Líu

et al. 2017

Oncol Lett

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“…As China’s cancer burden continues to grow, more attention has been directed toward effective prevention programs [33]. Overall cervical cancer mortality has been declining, but the declining trends showed only for older women; younger women showed an increasing trend [1]. Given the large population and limited resources in most areas of China, identifying the most at-risk populations and designing targeted prevention interventions are most efficient.…”

Section: Discussionmentioning

confidence: 99%

“…More than 80% of cervical cancer occurs in women in developing countries. As the most populous country, China has observed an increase in the cervical cancer incidence rate in younger females (25–44 years of age) within a context of a growing cancer burden [1,2]. For instance, the incidence rate of cervical cancer was 0.21 per 100,000 among women aged 20 to 24 from 1988 to 1992, but jumped to 1.35 per 100,000 from 1998 to 2002.…”

Section: Introductionmentioning

confidence: 99%

HPV and cervical cancer related knowledge, awareness and testing behaviors in a community sample of female sex workers in China

Hong

Zhang

et al. 2013

BMC Public Health

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BackgroundLimited data suggested that the prevalence of Human Papillomavirus (HPV) among female sex workers (FSW) is much higher than in the general female population. The current study aimed to examine the HPV and cervical cancer related awareness, knowledge, and behaviors among FSW in China.MethodsA total of 360 FSW recruited from entertainment establishments in Beijing completed a self-administered survey including demographics, HPV related knowledge, and health-seeking and cervical cancer preventive behaviors.ResultsApproximately 70.8% of the participants ever heard of cervical cancer, and as few as 22.1% and 13.3% ever heard of HPV and HPV vaccine, respectively. The mean score on a 7-item knowledge scale was 2.2 (SD = 2.4). Less than 10% of FSW perceived any risk of cervical cancer, and only 15.3% ever had a Pap smear. About 40.8% of FSW would accept HPV vaccine if it is free, and 21.8% would accept it even with a charge. Multivariate regression suggested that women with better knowledge of cervical cancer were more likely to have a Pap smear (aOR = 1.35); women who had tested for HIV were 11 times more likely to have a Pap smear, and women who had worked longer in commercial sex (aOR = 1.01) and had regular health check-ups (aOR = 1.95) were more likely to accept HPV vaccine.ConclusionsOur study underscores the needs for effective cervical cancer prevention programs for FSW in China and other resource-limited countries. We specifically call for cervical cancer and HPV knowledge and awareness programs and regular screening as well as HPV risk-reduction programs for these vulnerable women.

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“…More details about the 11 cities of cancer registries have been described previously (Li and Rao, 2000). More details about the 11 cities of cancer registries have been described previously (Li and Rao, 2000).…”

Section: Data Sourcesmentioning

confidence: 99%

Rural–urban, sex variations, and time trend of primary liver cancer incidence in China, 1988–2005

Gao

Xie

Chen

et al. 2013

European Journal of Cancer Prevention

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To investigate the incidence rate of primary liver cancer (PLC) in China in recent decades. Cancer registration data from 1988 to 2005 were used to analyze the incidence trends of PLC in 11 cities and counties in China. We estimated crude, age-specific, and age-standardized incidence rates of PLC. We also analyzed the annual percent change of incidence rate. From 1988 to 2005, a total of 97 462 liver cancer patients, among whom 75% were men, were diagnosed in the covered areas. The crude and age-standardized incidence rates in the combined population were 24.27/100 000 and 18.55/100 000, respectively. The age-standardized incidence rate was 28.15/100 000 for men and 9.31/100 000 for women. A decreasing trend was observed in the age-standardized incidence rate, with an annual percent change of -1.44% (P<0.05). Analysis on the basis of geographic location showed that the incidence rate was higher in rural areas than in urban areas. The crude and age-standardized incidence rates were 35.78/100 000 and 34.34/100 000 for rural areas and 21.64/100 000 and 15.72/100 000 for urban areas, respectively. During the past 18 years, the overall incidence rate of PLC had been decreasing gradually in 11 covered areas in China. Further studies are required to identify the risk factors influencing the incidence trend of liver cancer.

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Incidence and mortality trend of cervical cancer in 11 cancer registries of China

Cited by 23 publications

References 12 publications

E6/E7 proteins are potential markers for the screening and diagnosis of cervical pre‑cancerous lesions and cervical cancer in a Chinese population

E6/E7 proteins are potential markers for the screening and diagnosis of cervical pre‑cancerous lesions and cervical cancer in a Chinese population

HPV and cervical cancer related knowledge, awareness and testing behaviors in a community sample of female sex workers in China

Rural–urban, sex variations, and time trend of primary liver cancer incidence in China, 1988–2005

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