Incidence and Prevalence of Systemic Sclerosis in a Healthcare Plan in Buenos Aires

Rosa, Javier; Soriano, Enrique R.; Narvaez-Ponce, Lorena; Cid, Cecilia Castel del; Imamura, Patricia M.; Catoggio, Luís J.

doi:10.1097/rhu.0b013e31820e7e8d

Cited by 39 publications

(10 citation statements)

References 24 publications

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“…SSc is rare but can have poor prognosis and low survival rate. Its prevalence is 56.3–341 cases per million population [3, 4], but the incidence and prevalence of SSc have increased, particularly in the USA and Australia [5].…”

Section: Introductionmentioning

confidence: 99%

High risk of gastrointestinal hemorrhage in patients with systemic sclerosis

et al. 2019

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BackgroundSystemic sclerosis (SSc), a life-threatening autoimmune disease characterized by vasculopathy. Numerous SSc patients demonstrate gastrointestinal (GI) involvement but the delicate GI bleeding risk remains sparse. We aimed to explore the role of SSc in determining the long-term risk of GI bleeding, including bleedings of upper (peptic and non-peptic ulcers) and lower GI tracts.MethodsPatients with SSc diagnosis were identified from the Catastrophic Illness Patient Database and the National Health Insurance Research Database from 1998 to 2007. Each SSc patient was matched with five SSc-free individuals by age, sex, and index date. All individuals (case = 3665, control = 18,325) were followed until the appearance of a GI bleeding event, death, or end of 2008. A subdistribution hazards model was assessed to evaluate the GI bleeding risk with adjustments for age, sex, and time-dependent covariates, comorbidity, and medications.ResultsThe incidence rate ratios of GI bleeding were 2.38 (95% confidence interval [CI], 2.02–2.79), 2.06 (95% CI, 1.68–2.53), and 3.16 (95% CI, 2.53–3.96) for over-all, upper, and lower GI bleeding events in SSc patients. In the competing death risk in the subdistribution hazards model with time-covariate adjustment, SSc was an independent risk factor for over-all GI bleeding events (subdistribution hazard ratio [sHR] 2.98, 95% CI, 2.21–4.02), upper GI bleeding events (sHR 2.80, 95% CI, 1.92–4.08), and lower GI bleeding events (sHR 3.93, 95% CI, 2.52–6.13).ConclusionSSc patients exhibited a significantly higher risk of over-all and different subtype GI bleeding events compared with the SSc-free population. The prevention strategy is needed for these high GI bleeding risk groups.

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Section: Introductionmentioning

confidence: 99%

High risk of gastrointestinal hemorrhage in patients with systemic sclerosis

et al. 2019

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“…11 Another study carried out in Buenos Aires showed data very similar to ours, since they found a global prevalence of 29.6 per 100,000 inhabitants, with a prevalence in the female population of 47.7 per 100,000 inhabitants, and 2.8 per 100,000 inhabitants in the male population, as well as an average age at diagnosis of 66 years. 12 Another study that yielded similar results is the one conducted in Lugo, Spain, with a global prevalence of 27.7 per 100,000 inhabitants, 77% females. 13 A review made in Australia by Morrisroe et al 14 showed a prevalence of 23.3-86 per 100,000 inhabitants, with female predominance, with a maximum female:male ratio of 5:1.…”

Section: Discussionmentioning

confidence: 74%

Prevalence of systemic sclerosis in Colombia: Data from the National Health Registry 2012–2016

Fernández-Ávila

Bernal-Macías

Gutiérrez

et al. 2019

Journal of Scleroderma and Related Disorders

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Introduction: Systemic sclerosis is an autoimmune disease that characteristically presents with fibrosis and vasculopathy. In Latin America, the information on the epidemiology of this disease is scarce and records are essential to know its behavior in the populations. In Colombia, the Ministry of Health uses the SISPRO tool to collect information on the unified national health system which offers nearly universal coverage (around 95%). This public information makes it possible to perform epidemiological studies on different diseases. Objectives: Using the SISPRO data corresponding to the years 2012–2016, we analyzed the prevalence and characteristics of patients with systemic sclerosis. Methods: A descriptive cross-sectional study was performed based on the SISPRO data; we used as keywords the diagnoses of the International Classification of Diseases related to the diagnosis of systemic sclerosis. Results: A total of 11,300 individuals diagnosed with systemic sclerosis were documented. The estimated prevalence was 23.7 cases per 100,000 inhabitants (based on a total population of 47,663,162); this disease is more frequent in the age group of 65–69 years in females (77%), and has a female:male ratio of 3.27:1. Conclusion: This study describes the epidemiological characteristics of systemic sclerosis in Colombia, based on official statistics from the Ministry of Health. The results provide a new vision of this disease in Latin America and open the door to future research, in order to better understand the particular characteristics of this disease in our country and our region.

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“…Rosa et al utilized a retrospective analysis of electronic medical records from a hospital in Argentina to estimate the 2004 point prevalence and the incidence density of SSc from 1999 to 2004 . The estimated point prevalence of SSc in Argentina was 29.6 cases per 100 000 persons, following a broad case definition criterion, namely, a combination of ACR 1980 and/or Le Roy and Medsger 2001 criteria . The estimated incidence density was 2.12 cases per 100 000 person‐years …”

Section: Resultsmentioning

confidence: 99%

“…The estimated point prevalence of SSc in Argentina was 29.6 cases per 100 000 persons, following a broad case definition criterion, namely, a combination of ACR 1980 and/or Le Roy and Medsger 2001 criteria . The estimated incidence density was 2.12 cases per 100 000 person‐years …”

Section: Resultsmentioning

confidence: 99%

Prevalence and incidence of systemic sclerosis: A systematic review and meta‐analysis

et al. 2019

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Objective Systemic sclerosis (SSc) is a rare debilitating autoimmune disease of the connective tissue. This study aimed to assess the recent prevalence and incidence of SSc across the world. Methods Using a systematic search strategy, PubMed/MEDLINE and EMBASE were searched to identify relevant studies published between 2006 and 2016. Two reviewers independently evaluated studies for inclusion based on inclusion/exclusion criteria and performed data extraction. The review was conducted and reported following the Preferred Reporting Items for Systematic Review and Meta‐analysis (PRISMA) statement. The pooled prevalence of SSc was calculated by meta‐analysis using a random‐effects model. Results There were 1364 references retrieved using the initial searching strategy, and 20 epidemiological publications were selected for data extraction. The identified studies reported prevalence ranging from 3.8 per 100 000 in Taiwan to 50 per 100 000 in the USA. The prevalence was 23 per 100 000 (95% CI: 16‐29 per 100 000; 18 studies) in a pooled sample of 11 574 individuals. Incidence rate of SSc ranges from 0.77 per 100 000 person‐years in the Netherlands to 5.6 per 100 000 person‐years in the USA. SSc predominates in females with higher prevalence and incidence rates. It is important to note that different methodologies were used to derive these numbers so comparisons were made with caution. Conclusion This review provides an assessment of the current estimates of disease prevalence and incidence of SSc. The epidemiological burdens of SSc vary among different regions of the world. The epidemiological data need to be interpreted with caution considering the methodological differences in deriving these estimates.

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Incidence and Prevalence of Systemic Sclerosis in a Healthcare Plan in Buenos Aires

Abstract: Despite potential biases, these data are in agreement with others from different parts of the world and the first obtained in Argentina and, to our knowledge, in Latin America.

Cited by 39 publications

References 24 publications

High risk of gastrointestinal hemorrhage in patients with systemic sclerosis

High risk of gastrointestinal hemorrhage in patients with systemic sclerosis

Prevalence of systemic sclerosis in Colombia: Data from the National Health Registry 2012–2016

Prevalence and incidence of systemic sclerosis: A systematic review and meta‐analysis

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