Incidence and Prevalence of Systemic Sclerosis: A Systematic Literature Review

Chifflot, Hélène; Fautrel, Bruno; Sordet, Christelle; Chatelus, Emmanuel; Sibilia, Jean

doi:10.1016/j.semarthrit.2007.05.003

Cited by 386 publications

(293 citation statements)

References 34 publications

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“…SSc is a relatively rare connective tissue disease (prevalence ranged from 7 to 489 cases per million individuals [48]). It is characterized by early vasculopathy, autoantibody formation, lowgrade inflammation, enhanced collagen synthesis, and fibrosis in skin and internal organs.…”

Section: Hct For Systemic Sclerosismentioning

confidence: 99%

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Hematopoietic Cell Transplantation for Autoimmune Diseases: A Review of History, Current State, and Future Issues

Resnick¹,

Metodiev²,

Lazarova³

2017

Immunotherapy - Myths, Reality, Ideas, Future

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Autoimmune diseases are characterized by recurrent attacks and remissions, but as a rule they progress and eventually cause a severe disability and death. The present chapter contains general characteristics of autoimmune disease pathogenesis, ways to cause immune tolerance by hematopoietic cell transplantation (HCT), clinical aspects of the treatment for established autoimmune diseases with a special attention to multiple sclerosis (MS) and systemic sclerosis (SSc). A profound analysis of authors' point of view and of the available literature has been performed. The promising results allows to consider HCT as a relevant treatment option for a certain autoimmune diseases.

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Section: Hct For Systemic Sclerosismentioning

confidence: 99%

“…According to the recent published databases from Europe, North America, and South America, multiple sclerosis (followed by SSc) is constantly the most common indication for HCT [48,72,73].…”

Section: Hct For Multiple Sclerosismentioning

confidence: 99%

Hematopoietic Cell Transplantation for Autoimmune Diseases: A Review of History, Current State, and Future Issues

Resnick¹,

Metodiev²,

Lazarova³

2017

Immunotherapy - Myths, Reality, Ideas, Future

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show abstract

“…However, SSc is uncommon, with an estimated prevalence ranging from 7 to 489/million and incidence from 0.6 to 122/million/year 1 . This rarity has undoubtedly contributed to the paucity of randomized controlled trials examining the benefit of immunosuppression in this disease.…”

Section: To the Editormentioning

confidence: 99%

Observational Data to Study Medication Outcomes in Systemic Sclerosis: Table 1.

Hudson¹,

Baron²,

Steele³

2011

J Rheumatol

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“…Certain mechanisms such as lung fibrosis have been incriminated for lung cancer, the commonest coexisting cancer in scleroderma patients, but few data exist for other cancer types. Epidemiological correlations do not necessarily mean aetiological correlation, since they can be attributed to higher prevalence of both diseases in older ages 17 , female gender 18 or a diagnostic bias from close follow-up and extensive clinical investigation. Yet, there is some evidence that could support the existence of mechanisms that, in some extent, connect the two diseases.…”

Section: Pathophysiologymentioning

confidence: 99%