Incidence and Risk Factors for Venous Thromboembolism in Female Patients Undergoing Breast Surgery

Londero, Ambrogio P.; Bertozzi, Serena; Cedolini, Carla; Neri, Silvia Gonçalves Ricci; Bulfoni, Michela; ­Orsaria, Maria; Mariuzzi, Laura; Uzzau, Alessandro; Risaliti, Andrea; Barillari, Giovanni

doi:10.3390/cancers14040988

Cited by 12 publications

(10 citation statements)

References 60 publications

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“…Besides, we also found significant statistic differences in hypertension ratio and intraoperative hypotension time between the two groups. Although no significant statistic difference found in hypertension from multivariate logistic regression, a recent published study pointed invasive cancer, chronic hypertension, cancer type, and evidence of metastasis were the most significant risk factors for VTE in women who underwent breast surgery [22]. And a study aimed to assess the relationship between cardiovascular disease and the occurrence of VTE found that hypertension increased the risk of VTE in patients with newly diagnosed lung cancer, which may be mediated by inflammation [23].…”

Section: Discussionmentioning

confidence: 99%

Risk factors and potential predictors of pulmonary embolism in cancer patients undergoing thoracic and abdominopelvic surgery: a case control study

Liu

Chen

et al. 2022

Thrombosis J

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Background Postoperative pulmonary embolism (PE) is a severe complication leading to death and poor prognosis. The present study investigated the risk factors and potential predictors of PE in cancer patients undergoing thoracic and abdominopelvic surgery. Methods A retrospective study was conducted on the patients with cancer who underwent thoracic and abdominopelvic surgery in Sichuan Cancer Hospital from December 2016 to January 2022. A total of 189 patients were included, in which 63 patients diagnosed PE after operation were collected as PE group, and 126 patients matched by age, type of cancer and cancer location were enrolled as control group. Conditional logistic regression was conducted to analyze the association between PE and risk factors. Predictive values of key factors were compared by the area under the curve (AUC) in receiver operating characteristic curve (ROC) curve. Results Conditional multivariate logistic regression showed that BMI (odds ratio [OR] 4.065, 95% confidence interval [CI] 1.138–14.527; p = 0.031), intraoperative hypotension time (OR 4.095, 95% CI 1.367–12.266; p = 0.009), same day fluid balance (OR 0.245, 95% CI 0.061–0.684; p = 0.048), and postoperative D-Dimer (OR 1.693, 95% CI 1.098–2.611; p = 0.017) were significantly related to the occurrence of postoperative PE. Postoperative D-Dimer had the maximal AUC value 0.8014 (95% CI: 0.7260–0.8770) for predicting PE, with a cutoff value of 1.505 μg/ml. Conclusions BMI, intraoperative hypotension time, lower same day fluid balance and postoperative D-dimer are independent risk factors associated with PE in cancer patients undergoing thoracic and abdominopelvic surgery. Postoperative D-Dimer seems to be a good indicator to predict postoperative PE for cancer patients.

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Section: Discussionmentioning

confidence: 99%

Risk factors and potential predictors of pulmonary embolism in cancer patients undergoing thoracic and abdominopelvic surgery: a case control study

Liu

Chen

et al. 2022

Thrombosis J

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“…Our research found that age, temperature, amount of blood loss, PICC, chemotherapy, anemia, INR, and CA199 were independent risk factors for VTE, which was not exactly the same as previous studies. 10 , 13 , 22 , 32 PICC was recognized as an independent risk factor for thrombosis, the behavior leads to a hypercoagulable state of the blood and increases the risk of thrombosis by disrupting the Virchow triad. 23 , 24 Chemotherapeutic drugs can inhibit the synthesis of prostacylin, thrombomodulin, heparan sulfate, tissue factor pathway inhibitors, and plasminogen activator, thus facilitating the formation of venous thrombosis.…”

Section: Discussionmentioning

confidence: 99%

“…[9][10][11][12] A study of 5039 women who underwent breast surgery found that chronic hypertension, high body mass index, cancer type, and evidence of metastasis turned out to be the most significant risk factors for VTE. 13 A study had showed that independent predictors for VTE in metastatic CRC included female sex, African American race, prior VTE history, and right sided cancers. 14 However, there has not been a unified conclusion on the risk factors of VTE in inpatients with CRC in China and our study explored it to aid clinical prevention and treatment.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors of Venous Thromboembolism in Inpatients With Colorectal Cancer in China

Chen,

Sun,

Zhang

et al. 2023

Clin Appl Thromb Hemost

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To explore the risk factors for venous thromboembolism (VTE) in inpatients with colorectal cancer. The demographic factors, comorbidities, and hematological indices of patients with colorectal cancer treated in our hospital from 2016 to 2021 were collected and recorded. Venous thromboembolism events, including deep venous thrombosis and/or pulmonary embolism, were recorded and the patients were divided into the VTE group and the non-VTE group. We compared clinical data between the two groups and explored risk factors for VTE. Comparing the clinical data of 293 cases of non-VTE group and 235 cases of VTE group, we found significant differences in age, smoking, temperature, amount of blood loss, differentiation degree, peripherally inserted central catheter (PICC), radiotherapy, anemia, infection, white blood cell count, prothrombin time (PT), PT%, prothrombin ratio, international normalized ratio, thrombin time, CA199 and CEA between the two groups ( P < 0.05). Logistic regression analysis showed that age ( P = 0.0444), temperature ( P = 0.0317), amount of blood loss ( P = 0.0067), PICC ( P < 0.0001), chemotherapy ( P = 0.0459), anemia ( P = 0.0007), international normalized ratio ( P = 0.003) and CA199 ( p = 0.0234) were independent risk factors for VTE. Receiver operating characteristic curve analysis showed that the amount of blood loss predicted thrombosis better (AUC = 0.778, P < 0.001), when the cutoff value was 20 mL, the sensitivity was 76.17%, and the specificity was 79.18%, respectively. And PICC predicted thrombosis better (AUC = 0.808, P < 0.001), the sensitivity was 70.21%, and the specificity was 91.47%, respectively. Clinical parameters are associated with VTE in inpatients with colorectal cancer, which will help to guide clinicians to take effective measures to improve the patients' prognosis.

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“…Among women who underwent breast surgery, chronic hypertension, high body mass index (BMI), cancer type, and evidence of metastasis were noted as the most significant risk factors for VTE, while type of breast surgery, type of axilla surgery, type of plastic surgery did not increase risk of VTE [25]. Also, hospital length of stay >3 days, and general anesthesia were noted as risk factors of developing VTE in patients undergoing reconstructive BC surgery [26].…”

Section: Surgerymentioning

confidence: 99%

Adverse effects in the management of breast cancer – recent studies

Maksymowicz,

Machowiec,

Korzeniowska

et al. 2023

J Educ Health Sport

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Introduction and purpose Breast cancer (BC) management includes local therapies surgery, radiotherapy and systemic – hormonotherapy, chemotherapy, targeted and immunotherapy. However, some adverse events of these treatment strategies limit their wide administration in BC therapy. The aim of the study was to present adverse effects in the management of BC, prevention and treatment of them. State of the knowledge Surgery of the breast leads to lymphedema, pain, and anatomical changes. The most characteristic adverse event of radiotherapy is radiation dermatitis which is more probable among obese, older patients, females, and smokers. Other side effects are pneumonia, cardiac and pulmonary injury. Chemotherapeutics lead to complications such as anthracyclines-induced cardiotoxicity. As a consequence of endocrine therapy, patients are affected by vasomotor, musculoskeletal, and vulvovaginal symptoms. Immune checkpoint inhibitors may cause immune-related adverse events (irAEs), which are usually mild. When severe irAEs occur, immunosuppressive drugs are used. Depending on stage, toxicities of the therapies can lead to interrupting the treatment of BC. Moreover, drug resistance is an important therapeutic obstacle in BC treatment. Conclusion The application of a diversity of drugs in the treatment of breast cancer is associated with adverse effects which limit its efficacy. It is vital to develop novel, targeted therapeutic methods to optimize outcomes of patients. Given the adverse effects of breast cancer therapies and drug resistance, it is vital to develop novel, targeted therapeutic methods.

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Incidence and Risk Factors for Venous Thromboembolism in Female Patients Undergoing Breast Surgery

Cited by 12 publications

References 60 publications

Risk factors and potential predictors of pulmonary embolism in cancer patients undergoing thoracic and abdominopelvic surgery: a case control study

Risk factors and potential predictors of pulmonary embolism in cancer patients undergoing thoracic and abdominopelvic surgery: a case control study

Risk Factors of Venous Thromboembolism in Inpatients With Colorectal Cancer in China

Adverse effects in the management of breast cancer – recent studies

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