Incidence and Risk Factors for Frailty in the Community-Dwelling Elderly Population. A Two-Year Follow-Up Cohort Study

Serra‐Prat, Mateu; Papiol, Mònica; Vico, J. P.; Palomera, Elísabet; M, Arús; Cabré, Mateu

doi:10.4172/2167-7182.1000452

Cited by 7 publications

(7 citation statements)

References 33 publications

(46 reference statements)

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“…This study has successfully reported the incidence rate of CF at a rate of 7.1 per 100 person-years among older adults who did not exhibit CF at the baseline. The incidence rate of mild cognitive impairment (MCI) and physical frailty was 10.5 and 6.8 per 100 person-years, as reported in previous local studies [38,39]. Accordingly, the incidence rate of CF from the recent study was relevant and proportional to the reported incidence rate for both geriatric syndromes.…”

Section: Discussionsupporting

confidence: 59%

Incidence and Predictors of Cognitive Frailty Among Older Adults: A Community-based Longitudinal Study

Rivan

Shahar

Rajab

et al. 2020

IJERPH

104

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1) Background: Cognitive frailty (CF) is the simultaneous presence of physical frailty and cognitive impairment with an increased risk of dementia. Considering that the risk factors of CF are mostly elucidated from cross-sectional studies, we conducted a community-based longitudinal study to determine the incidence and the predictors of CF among Malaysian older adults.; (2) Methods: Out of 490 older adults participating in the Malaysian Towards Useful Aging (TUA) study, 282 were successfully followed-up at five-years for an analysis of the CF incidence. CF was defined as a comorbid physical frailty (>1 Fried criteria) and mild cognitive impairment (Petersen criteria). A comprehensive interview-based questionnaire was administered for sociodemographic information, cognitive function, physical function, dietary intake, psychosocial, and biochemical indices. Univariate analyses were performed for each variable, followed by a regression analysis to identify the predictors of CF that accounted for confounding effects between the studied factors; (3) Results: The incidence Int.rate of CF was 7.1 per 100 person-years. Advancing age (OR=1.12, 95% CI:1.04-1.21, p < 0.05), depression (OR=1.20, 95% CI:1.05-1.37, p < 0.05), decreased processing speed, assessed by a lower digit symbol score (OR=0.67, 95%CI:0.0.56-0.80, p < 0.05), decreased functional mobility measured using Timed-Up-and-Go (TUG) (OR=1.23, 95% CI:1.04-1.46, p < 0.05), low vitamin D intake (OR:0.36, 95% CI:0.14-0.93, p < 0.05) and physical frailty (OR=2.16, 95% CI:1.02-4.58, p < 0.05) were predictors for CF incidence; and (4) Conclusions: Our study results could be used as an initial reference for future studies to formulate effective preventive management and intervention strategies to decelerate CF development among older adults.

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Section: Discussionsupporting

confidence: 59%

Incidence and Predictors of Cognitive Frailty Among Older Adults: A Community-based Longitudinal Study

Rivan

Shahar

Rajab

et al. 2020

IJERPH

104

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“…To estimate the global incidence of frailty, data were included from 46 studies. 41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,83,84,85,86 Among people without frailty at baseline who survived a median follow-up of 3.0 (range, 1.0-11.7) years, 13.6% (13 678 of 100 313) became frail. The pooled incidence rate of frailty was 43.4 (95% CI, 37.3-50.4; I 2 = 98.5%) cases per 1000 person-years (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-one studies 41,42,46,51,53,57,59,60,65,66,67,68,69,71,72,77,79,80,81,82,83 reported data on the global incidence of prefrailty among 32 268 community-dwelling older adults who were robust at baseline and survived a median follow-up of 2.5 (range, 1.0-10.0) years. During the follow-up, 30.9% (9974 of 32 268) became prefrail.…”

Section: Resultsmentioning

confidence: 99%

“…Prevention of frailty requires a sound understanding of the risk factors. For example, it has been demonstrated that individual chronic diseases (eg, cancers, type 2 diabetes, 63,66,71 and depression, 77,85,87 or their co-occurrence [ie, multimorbidity]) have been shown to increase the risk of frailty. 88,89 With an estimated 66% of older people having at least 2 chronic medical conditions, 90 effective preventive strategies are paramount to reduce overall disease burden.…”

Section: Discussionmentioning

confidence: 99%

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Global Incidence of Frailty and Prefrailty Among Community-Dwelling Older Adults

et al. 2019

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IMPORTANCE Frailty is a common geriatric syndrome of significant public health importance, yet there is limited understanding of the risk of frailty development at a population level. OBJECTIVE To estimate the global incidence of frailty and prefrailty among community-dwelling adults 60 years or older.DATA SOURCES MEDLINE, Embase, PsycINFO, Web of Science, CINAHL Plus, and AMED (Allied and Complementary Medicine Database) were searched from inception to January 2019 without language restrictions using combinations of the keywords frailty, older adults, and incidence. The reference lists of eligible studies were hand searched. STUDY SELECTIONIn the systematic review, 2 authors undertook the search, article screening, and study selection. Cohort studies that reported or had sufficient data to compute incidence of frailty or prefrailty among community-dwelling adults 60 years or older at baseline were eligible. DATA EXTRACTION AND SYNTHESISThe methodological quality of included studies was assessed using The Joanna Briggs Institute's Critical Appraisal Checklist for Prevalence and Incidence Studies.Meta-analysis was conducted using a random-effects (DerSimonian and Laird) model. MAIN OUTCOMES AND MEASURESIncidence of frailty (defined as new cases of frailty among robust or prefrail individuals) and incidence of prefrailty (defined as new cases of prefrailty among robust individuals), both over a specified duration. RESULTSOf 15 176 retrieved references, 46 observational studies involving 120 805 nonfrail (robust or prefrail) participants from 28 countries were included in this systematic review. Among the nonfrail individuals who survived a median follow-up of 3.0 (range, 1.0-11.7) years, 13.6% (13 678 of 100 313) became frail, with the pooled incidence rate being 43.4 (95% CI, 37.3-50.4; I 2 = 98.5%) cases per 1000 person-years. The incidence of frailty was significantly higher in prefrail individuals than robust individuals (pooled incidence rates, 62.7 [95% CI, 49.2-79.8; I 2 = 97.8%] vs 12.0 [95% CI, 8.2-17.5; I 2 = 94.9%] cases per 1000 person-years, respectively; P for difference < .001). Among robust individuals in 21 studies who survived a median follow-up of 2.5 (range, 1.0-10.0) years, 30.9% (9974 of 32 268) became prefrail, with the pooled incidence rate being 150.6 (95% CI, 123.3-184.1; I 2 = 98.9%) cases per 1000 person-years. The frailty and prefrailty incidence rates were significantly higher in women than men (frailty: 44.8 [95% CI, 36.7-61.3; I 2 = 97.9%] vs 24.3 [95% CI, 19.6-30.1; I 2 = 8.94%] cases per 1000 person-years; prefrailty: 173.2 [95% CI, 87.9-341.2; I 2 = 99.1%] vs 129.0 (continued) Key PointsQuestion What is the incidence of frailty and prefrailty among communitydwelling adults 60 years or older?Findings In this systematic review and meta-analysis involving data from more than 120 000 older adults from 28 countries, the incidence of frailty and prefrailty was estimated as 43.4 and 150.6 new cases per 1000 person-years, respectively. The frailty and prefrailty incidence rates varied by ...

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“…15 In a 2-year cohort study also showed that low physical activity and depression as risk factors for frailty. 16 Other variables such as age, educational level, BMI, and disability do not show significant relationship with frailty. This study recruited a sample from an urban area with middle socioeconomic status, which differentiates this study from another study in Malaysia that recruited a sample in a rural area with a low socioeconomic status.…”

Section: Discussionmentioning

confidence: 92%

Low Bone Mineral Density, Sedentary Lifestyle, and Depression as Risk Factors for Frailty Syndrome at a Home Care Facility in West Jakarta, Indonesia

Handajani

Subagya

Widjaja

2023

AMJ

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Background: The life expectancy in Indonesia is increasing. The rising number of the elderly people plays a vital role for a country to achieve development success. However, it has many consequences in the health sector, including a frailty syndrome. This study aimed to explore the association between frailty and related factors.Methods: This cross-sectional study was conducted at a home care facility in West Jakarta between September and October 2019, using a simple random sampling method. Data were analyzed using the chi-square test and multivariate logistic regression. The inclusion criteria were members of the home care aged ≥60 years and had signed a written informed consent.Results: In total, 97 respondents were included. Female gender and bone mineral density (BMD) were associated with frailty syndrome (p=0.018 and p=0.05, respectively). Multivariate logistic regression analysis showed the odds ratio of frailty for the female gender (OR= 3.319; 95% CI 1.045–10.543), low bone mineral density (OR= 4.939; 95% CI 1.516–16.090), depression (OR= 7.622; 95% CI 1.246 – 46.621), and low physical activity (OR = 3.639; 95% CI 1.096 – 12.079).Conclusions: There is a relationship between female gender and bone mineral density with frailty syndrome with the risk factors for frailty syndrome in this study are female gender, low bone mineral density, depression, and low physical activity.

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Incidence and Risk Factors for Frailty in the Community-Dwelling Elderly Population. A Two-Year Follow-Up Cohort Study

Abstract: Background: Frailty is a highly prevalent geriatric syndrome and a major public health problem. Designing effective preventive measures requires an understanding of frailty mechanisms and risk factors.

Cited by 7 publications

References 33 publications

Incidence and Predictors of Cognitive Frailty Among Older Adults: A Community-based Longitudinal Study

Incidence and Predictors of Cognitive Frailty Among Older Adults: A Community-based Longitudinal Study

Global Incidence of Frailty and Prefrailty Among Community-Dwelling Older Adults

Low Bone Mineral Density, Sedentary Lifestyle, and Depression as Risk Factors for Frailty Syndrome at a Home Care Facility in West Jakarta, Indonesia

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