Incidence and risk factors for oral mucositis in pediatric patients receiving chemotherapy

Curra, Marina; Gabriel, Amanda F; Ferreira, Maria Beatriz Cardoso; Martins, Marco Antônio Trevizani; Brunetto, André T.; Gregianin, Lauro José; Martins, Manoela Domingues

doi:10.1007/s00520-021-06199-5

Cited by 26 publications

(29 citation statements)

References 43 publications

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“…Due to the usage of different laser devices, there was a difference in handpieces and thus the surface of the light beam or spot size. The authors used wavelengths ranging from 660 to 980 nm; some of them used a light source that emitted two different wavelengths simultaneously [ 13 , 20 , 25 ]. One study used different wavelengths according to OM grades on the World Health Organization (WHO) scale; they used the longer one for higher OM grades [ 4 ].…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, some drugs used in different chemotherapy (CT) protocols display a higher cytotoxic potential than others, one example being methotrexate (MTX) alone or in combination with other agents. They are first used in the treatment of acute lymphoblastic leukemia (ALL)—the most common childhood malignancy—and conditioning regiments prior to HSCT [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Photobiomodulation for Chemotherapy-Induced Oral Mucositis in Pediatric Patients

et al. 2023

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Oral mucositis (OM) is a common side effect in patients undergoing chemotherapy (CT), especially in children due to their rapid epithelial mitotic rate. It has been associated with a significant reduction in life quality since it leads to pain, an inadequate intake of nutrients, an increased risk of opportunistic infections, and interruptions of CT. Photobiomodulation (PMB) with low-level laser therapy (LLLT) has shown faster healing, reduction in pain, and the reduced use of analgesic compared to placebo groups. The purpose of this review is to analyze and compare the existing clinical trials and identify their shortcomings in hope to make future research easier. Using MeSH terms and keywords, the Embase, Medline, and PubMed databases we searched for the period of the last 5 years. We identified a total of 15 clinical trials, with a total of 929 pediatric patients analyzed in this review. We compared different light sources and other laser technique characteristics used in clinical trials such as wavelength, energy and power density, spot size, irradiation time, PBM protocol, and OM evaluation. The main findings show inconsistent laser parameter quotations, differences in the PBM protocol along with a laser application technique, and a lack of clinical trials. Based on that, more studies with a high methodological quality should be conducted in order to provide a unified PBM protocol suitable for the pediatric population.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Photobiomodulation for Chemotherapy-Induced Oral Mucositis in Pediatric Patients

et al. 2023

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“…Several changes occur to the oral cavity throughout the intensive cancer chemotherapy courses. Decreased saliva production resulting in xerostomia 10 and oral mucositis 11 are reported adverse effects of CYP.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of hesperidin in cyclophosphamide-induced parotid toxicity in rats

Mostafa

Ibrahim

Borai

2023

Sci Rep

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Cyclophosphamide (CYP) is an alkylating agent that is used on a wide range as a treatment of malignancies and autoimmune diseases. Previous studies have shown the promising role of hesperidin (HSP) as an antioxidant agent against various models of toxic agents. The protective effect of the HSP against CYP-induced parotid damage was evaluated in this study. Forty rats (180–200 g) were divided into four equal groups: Group I (received normal saline), Group II (HSP-treated at a dose of 100 mg/kg/day for 7 consecutive days), Group III (CYP-treated at a dose of 200 mg/kg single intraperitoneal injection on the 7th day of the experiment), Group IV (CYP + HSP); HSP-treated at a dose of 100 mg/kg/day for 7 consecutive days and CYP (200 mg/kg) single intraperitoneal injection on the 7th day of the experiment. Afterwards, the oxidative stress and inflammatory markers, the histopathological and immunohistochemical alterations of the parotid tissues in the studied groups were evaluated. CYP intoxication induced a significant parotid tissue injury represented by the elevation in the values of malondialdehyde (MDA), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) and decrease in the catalase activity and glutathione peroxidase (GPx). Histologically, extensive histopathological alterations e.g., widely spaced serous acini with irregular shapes and congested blood vessels as well as downregulated ki-67 and alpha-smooth muscle actin (α-SMA) immunoexpression were induced by CYP. HSP administration markedly improved the biochemical and the histopathological studies. We can conclude that HSP elicited protective effects against the CYP-induced parotid toxicity.

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“…7 Oral mucositis makes feeding difficult and may also increase the risk of infection, limit the dose of the medication, delay the treatment, and extend hospital stay. 8 The role of reactive oxygen species (ROS) and various pro-inflammatory cytokines in the pathogenesis of mucositis have been shown. 9 It has also been showed that MTX increases the levels of malondialdehyde (MDA), an oxidant parameter in the oral mucosa, interleukin 1 beta (IL-1β), and tumor necrosis factor alpha (TNF-α), an indicator of inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

Effect of taxifolin on methotrexate-induced oxidative and inflammatory oral mucositis in rats: biochemical and histopathological evaluation

et al. 2022

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Effect of taxifolin on methotrexateinduced oxidative and inflammatory oral mucositis in rats: biochemical and histopathological evaluationThe role of oxidative stress, as well as inflammation in the pathogenesis of methotrexate (MTX)-induced oral mucositis, is a known fact. The antiinflammatory, antitumor, antimicrobial, and antioxidant properties of taxifolin-the effect we tested against MTX-induced oral mucosal damage-are well known. Objective: Evaluating biochemically and histopathologically the effects of taxifolin on methotrexate-induced oral mucosal damage in rats.Methodology: In the taxifolin+MTX (TMTX) group, 50 mg/kg taxifolin was orally administered to rats by gavage. In the MTX and healthy (HG) groups, normal saline was applied to rats as solvent by the same method. One hour after administration of taxifolin and solvent, 5 mg/kg MTX was orally administered to rats in the MTX and TMTX groups. Taxifolin and methotrexate were administered once a day for 30 days. Macroscopic, biochemical, and histopathological evaluations were performed on the inner cheek and tongue tissues of rats. These parts were removed after rats were killed with a highdose anesthesia. Results: Taxifolin with MTX prevented the increase in oxidant and pro-inflammatory parameters, such as malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), interleukin 6 (IL-6), on the inner cheek and tongue tissues of rats. Moreover, taxifolin antagonized the decrease in total glutathione (tGSH). Taxifolin decreased MTX-induced histopathological damage. Conclusion: These findings suggest that taxifolin may be useful to treat MTX-associated oral mucositis.

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Incidence and risk factors for oral mucositis in pediatric patients receiving chemotherapy

Cited by 26 publications

References 43 publications

Photobiomodulation for Chemotherapy-Induced Oral Mucositis in Pediatric Patients

Photobiomodulation for Chemotherapy-Induced Oral Mucositis in Pediatric Patients

Protective effects of hesperidin in cyclophosphamide-induced parotid toxicity in rats

Effect of taxifolin on methotrexate-induced oxidative and inflammatory oral mucositis in rats: biochemical and histopathological evaluation

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