Incidence and risk factors of retinopathy of prematurity in Korle-Bu Teaching Hospital: a baseline prospective study

Braimah, Imoro Zeba; Enweronu‐Laryea, Christabel; Sackey, Adziri H.; Kenu, Ernest; Agyabeng, Kofi; Ofori-Adjei, Imelda-Odille Dziffa-Bella; Beyuo, Vera M.; Oku, Aaron; Essuman, Vera Adobea

doi:10.1136/bmjopen-2019-035341

Cited by 13 publications

(15 citation statements)

References 42 publications

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“…Also, for the index study, ROP was seen in 25.9% of babies weighing ≤ 1500 g and 15.4% of babies delivered with BW >1500 g, suggesting that ROP could be more commonly found in smaller preterm infants (the results were the same using the mean weight of our study, 1400 g). A similar trend is reported in some reports from Ibadan, Nigeria[ 1 ]; Accra Ghana[ 18 ]; and Hamadan, Iran. [ 19 ] It is noteworthy that in Rwanda, nearly a fifth of all babies with ROP were larger than the American Academy of Ophthalmology guideline.…”

Section: Discussionsupporting

confidence: 90%

“…The incidence of ROP in our hospital at 21% is higher than earlier reports from Ibadan, Nigeria (12.2%),[ 1 ] Lagos, Nigeria (15%),[ 17 ] Ghana (13.7%),[ 18 ] Rwanda (7.3%),[ 8 ] but much less than the 30% reported from Iran,[ 19 ] Port Harcourt, Nigeria (47.2%),[ 4 ] Kenya (41.7%),[ 20 ] and Oman (46.4%). [ 21 ] However, the incidence recorded in this report is similar to the 19.2% reported in Egypt.…”

Section: Discussioncontrasting

confidence: 60%

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Retinopathy of Prematurity in the University of Calabar Teaching Hospital, Calabar, Nigeria

Udoh

Nkanga

Agweye

et al. 2021

Journal of West African College of Surgeons

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Background: Retinopathy of prematurity (ROP) is an important cause of childhood blindness worldwide. This blindness is avoidable through regular screening of preterm infants and prompt intervention for those with the condition. Aims/Objectives: This study aimed to determine the pattern of presentation of ROP and the risk factors for its development among preterm infants in the Neonatal Unit of the University of Calabar Teaching Hospital, Calabar, Nigeria. Design of Study: This study is a prospective, longitudinal study. Settings: The study was carried out in the Special Care Baby Unit, Sick Baby Unit, and Neonatal Clinic of the Department of Paediatrics and Child Health, University of Calabar Teaching Hospital, Calabar, Nigeria. Materials and Methods: All preterm infants whose mothers had given informed consent to participate were enrolled. Ocular examination was performed by a trained ophthalmologist. ROP was staged and documented using the revised version of the International Classification of ROP. Data were entered into a questionnaire and analysed using IBM SPSS version 22. Results: Of the 53 neonates recruited into the study, ROP was detected in 11 (21%) neonates, of which 9 (82%) had stage 1 disease, 2 (18%) had stage 2, and none had stage 3. ROP was more common in females, 7 (63.6%), than their male counterparts 4 (36.4%). ROP was higher among those with gestational age (GA) ≤30 weeks [9 (81.8%)] when compared with those with GA >30 weeks [2 (18.2%)] ( P = 0.016). Other risk factors for ROP assessed by this study were found not to be significantly associated with the occurrence of ROP. Conclusion: ROP was present in 21% of the neonates, and the majority had stage 1 disease. This finding emphasizes the need for screening of all preterm neonates for ROP in order to forestall avoidable blindness which could result from this condition.

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Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 60%

Retinopathy of Prematurity in the University of Calabar Teaching Hospital, Calabar, Nigeria

Udoh

Nkanga

Agweye

et al. 2021

Journal of West African College of Surgeons

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“…Infants who receive unrestricted oxygen in units without the capacity to blend oxygen/air are at increased risk of developing severe ROP [4]. This may contribute to the observations from previous studies that larger and/or more mature infants (≥1500 g and/or ≥32 weeks gestational age) are developing ROP in sub-Saharan Africa [18][19][20][21][22][23][24][25]. A compressed oxygen source was available in every unit, but many units did not have the capacity to blend oxygen/air because of lack of compressed medical air, precluding the use of traditional blenders.…”

Section: Discussionmentioning

confidence: 99%

Oxygen management among infants in neonatal units in sub-Saharan Africa: a cross-sectional survey

et al. 2021

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Objectives To provide more comprehensive data on the management of oxygen supplementation in neonates in sub-Saharan Africa.Study design An online survey on the management of oxygen supplementation for infants in neonatal units was sent to 278 healthcare personnel in sub-Saharan Africa.Results One hundred and nine responses from 82 neonatal care units in 54% (26/48) sub-Saharan African countries were received. All units had the capacity to provide oxygen supplementation. However, only 50% (38/76) had access to blend oxygen with medical air and 1% (1/75) had the capacity to blend oxygen/air for every infant. Although 96% (72/75) of units could monitor oxygen saturation, monitoring was mostly intermittent and only 32% (24/75) were able to monitor oxygen saturation in every infant receiving oxygen supplementation. Conclusions Findings indicate that oxygen supplementation is inadequately managed in neonatal units in sub-Saharan Africa, which may put infants at risk of developing severe ROP.

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“…It stems from incomplete vascularization of the retina in preterm infants, causing ischemia and consequent abnormal vascularization and fibrosis [ 4 ]. Major risk factors for development of ROP include low birth weight, low gestational age, a history of blood transfusion, sepsis, intraventricular haemorrhage, and necrotizing colitis [ 5 , 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Haemoglobin Levels in Early Life among Infants with and without Retinopathy of Prematurity

Pheng

Lim

Tai

et al. 2021

IJERPH

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Retinopathy of prematurity (ROP) is a proliferative retinal vascular disorder attributed to an ischaemic stimulus in preterm infants. Haemoglobin, the main component for oxygen transportation, may be implicated in ROP development. This retrospective study compared the mean weekly haemoglobin levels between infants with and without ROP over the first six weeks of life. Premature infants of less than 32 weeks gestational age and less than 1.5 kg birth weight were grouped into age and birth weight-matched ROP cases and controls. Weekly mean haemoglobin levels were documented. An independent t-test was used to analyze the difference in mean haemoglobin levels between infants with ROP and infants without ROP. Adjustment for confounders was performed using one-way analysis of covariance. There was a statistically significant difference in adjusted mean haemoglobin levels between the ROP and non-ROP group during the first week of life (p = 0.038). No significant intergroup differences were observed at the other weeks. Haemoglobin monitoring during the first week of postnatal life may be useful to guide ROP screening in premature infants.

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Incidence and risk factors of retinopathy of prematurity in Korle-Bu Teaching Hospital: a baseline prospective study

Cited by 13 publications

References 42 publications

Retinopathy of Prematurity in the University of Calabar Teaching Hospital, Calabar, Nigeria

Retinopathy of Prematurity in the University of Calabar Teaching Hospital, Calabar, Nigeria

Oxygen management among infants in neonatal units in sub-Saharan Africa: a cross-sectional survey

Haemoglobin Levels in Early Life among Infants with and without Retinopathy of Prematurity

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