Incidence and risk factors of atherosclerotic cardiovascular accidents in predialysis chronic renal failure patients: a prospective study

Jungers, Paul; Massy, Ziad A.; Khoa, Thao Nguyen; Fumeron, Christine; Labrunie, M.; Lacour, Bernard; Descamps‐Latscha, Béatrice; Man, N. K.

doi:10.1093/ndt/12.12.2597

Cited by 281 publications

(191 citation statements)

References 3 publications

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“…28 There is a high prevalence of atherosclerosis in CKD. 29,30 Atherosclerotic lesions in kidney failure are frequently calcified, as opposed to fibroatheromatous, and have increased media thickness compared with lesions in the general population. 31 Surrogates of atherosclerosis include both intima-media thickness of the carotid wall that is detectable by ultrasound and inducible myocardial ischemia that is detectable by coronary stress tests.…”

Section: Spectrum Of Cvd In Ckd and Differences From The General Popumentioning

confidence: 99%

Kidney Disease as a Risk Factor for Development of Cardiovascular Disease

Sarnak¹,

Levey²,

Schoolwerth³

et al. 2003

Circulation

3,061

752

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Section: Spectrum Of Cvd In Ckd and Differences From The General Popumentioning

confidence: 99%

Kidney Disease as a Risk Factor for Development of Cardiovascular Disease

Sarnak¹,

Levey²,

Schoolwerth³

et al. 2003

Circulation

3,061

752

View full text Add to dashboard Cite

“…Patients with chronic kidney disease have been believed to have elevated inflammation markers, leading to a state of accelerated atherosclerosis, which may partially cause worse clinical outcomes as an eGFR became lower. 25,[28][29][30] Other explanations may be conditions associated with Figure 3 Kaplan-Meier survival curves (a), cardiovascular event-free curves (b), readmission for heart failure-free curves (c) and target lesion revascularization (TLR)-free curves (d) among patients undergoing percutaneous coronary intervention (n¼426) according to the estimated glomerular filtration rate (GFR) value. Cardiovascular events were composed of cardiac death, nonfatal myocardial infarction or readmission for heart failure.…”

Section: Clinical Outcomesmentioning

confidence: 99%

Impact of reduced renal function on prognosis in Japanese patients with coronary artery disease: a prospective cohort of Shinken Database 2007

et al. 2009

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Patients with coronary artery disease (CAD) frequently have impaired renal function, but the prevalence and influence of renal dysfunction on their prognosis in Japan remain uncertain. With a prospective study comprising all the new patients who had visited our hospital between 2004 and 2007 (n¼6562), we investigated the prevalence of renal dysfunction and its influence on the prognosis of CAD patients. The glomerular filtration rate (GFR) was calculated by using the GFR equation used for the Japanese population. Of those, 797 patients with CAD and blood tests available were analyzed (median follow-up periods of 693 days). Patients were further classified into four subgroups according to estimated GFR value (eGFR): normal (90peGFR, 12.2%), mildly impaired (60peGFRo90, 58.3%), moderately impaired (30peGFRo60, 23.6%) and severely impaired renal function (eGFRo30, 5.9%). The 2-year survival and cardiovascular event (cardiac death, nonfatal myocardial infarction or readmission for heart failure)-free rates were significantly different among the four subgroups: 98.9, 97.7, 89.3 vs. 67.8%, respectively (Po0.001 for trend), and 100, 98.8, 89.0 vs. 70.0%, respectively (Po0.001 for trend). The age-and gender-adjusted mortality increased significantly in moderately impaired (hazard ratio (HR) 3.1, 95% confidence interval (CI) 1.383-7.017) and in severely impaired subgroups (HR 10.1, 95% CI 4.244-24.178) compared with those with eGFR of 60 or more. After adjustment for baseline differences, eGFR was independently associated with death and cardiovascular events (HR 0.983 and 0.981, 95% CI 0.968-0.998 and 0.965-0.998, respectively). In conclusion, our study identified the prevalence and association of eGFR with prognosis in Japanese patients with CAD, suggesting that strict care for not only CAD but also renal dysfunction is needed for further prevention of cardiovascular events.

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“…tients [22], patients with a recent stroke [23] or a myocarNo violations of the Cox's proportional hazard asdial infarction [24], patients at high risk of cardiovascular sumption were observed. [2,3,30].…”

Section: Estimates Of Renal Function and All-cause And Cardiovascularmentioning

confidence: 99%

Mild renal insufficiency is associated with increased cardiovascular mortality: The Hoorn Study

et al. 2002

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The mechanism behind this association is unclear but does not Mild renal insufficiency is associated with increased cardiovasappear to involve common risk factors such as hypertension, cular mortality: The Hoorn Study.diabetes or hyperhomocysteinemia. Estimation of renal funcBackground. Cardiovascular mortality is extremely high in tion by relatively simple methods therefore may be a valuable end-stage renal disease. Cardiovascular mortality risk also is tool for cardiovascular risk assessment over and above that increased in selected (high-risk) individuals with mild to modprovided by conventional risk factors. Our results were oberate impairment of renal function. It is not clear whether a tained in a general middle-aged to elderly population, and thus similar association exists in the general population and, if so, have broad applicability. through what mechanisms. We investigated the association of renal function with all-cause and cardiovascular mortality in a population-based cohort and explored potential mechanisms underlying any such relationship.End-stage renal disease is strongly associated with risk accurate [7]. However, it is not known whether these In view of these considerations, in a prospective, popuof GFR. These associations remained after adjusting for age, lation-based study, we investigated whether these estimates sex, glucose tolerance status, hypertension, prior cardiovascuof renal function were associated with cardiovascular morlar disease, low-density lipoprotein cholesterol, homocysteine, tality. In addition, we explored potential mechanisms to with both impaired renal function and cardiovascular disease [4,8].

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Incidence and risk factors of atherosclerotic cardiovascular accidents in predialysis chronic renal failure patients: a prospective study

Cited by 281 publications

References 3 publications

Kidney Disease as a Risk Factor for Development of Cardiovascular Disease

Kidney Disease as a Risk Factor for Development of Cardiovascular Disease

Impact of reduced renal function on prognosis in Japanese patients with coronary artery disease: a prospective cohort of Shinken Database 2007

Mild renal insufficiency is associated with increased cardiovascular mortality: The Hoorn Study

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