Incidence and tumor characteristics of breast cancer diagnosed before and after implementation of a population-based screening-program

Cyclooxygenase-2 Inhibition for the Prophylaxis and Treatment of Preinvasive Breast Cancer in a Her-2/Neu Mouse Model

“…It has been diagnosed with increasing frequency since the introduction of mammographic screening programs (1). Following lumpectomy, close to 30% of cases of DCIS will recur, and of those that recur, approximately half will recur as invasive breast cancer (2).…”

Mammography, Martin Yaffe, and Me: Response and Appreciation

“…However, the discussion serves indirectly to bring out an important observation: that besides its traditionally accepted benefits in detection of earlier-stage disease, mammography also contributes to substantial reductions in the incidence of advanced or metastatic breast cancer [26][27][28][29][30][31][32][33][34] as was noted in a review of mammography screening rcts 35 . As Tabár's team demonstrated, trials reducing such advanced stage disease by at least 20% confer a 28% mortality reduction in screening-invited women, translating to an approximately 40% mortality reduction in screening-attendant women, compared with trials effecting a less than 10% reduction in advanced cancer, which were associated with no significant breast cancer mortality reduction 27,36 .…”

Performance and effectiveness of organised breast cancer screening in Finland

“…The process and validity parameters among the 50-69 years old invitees have been reported intensively (Wang et al 2001a, Wang et al 2001b, Hofvind et al 2004a, Hofvind et al 2004b, Hofvind et al 2006a, Hofvind et al 2007a, Hofvind et al 2007b). The overall attendance rate during the first ten years of the programme was 76%, the recall rates in the first and subsequent screens 4.6% and 2.6%, and the detection rates for the screen-detected cancers 0.64% and 0.49%, respectively.…”

“…The episode sensitivity by the incidence method within the first year after mammography screening was 72%, and within the second year 34-36% (Hofvind et al 2006a, Hofvind et al 2007a). The impact of screening on the incidence and tumour characteristics of breast cancer was studied in 1996-2004 (Hofvind et al 2007b). Breast cancers diagnosed in the screening period had more favourable characteristics than those in the prescreening period, but the decline in advanced cancers after the first years of screening was not clearly apparent.…”