Incidence, Mortality and Prevalence as Indicators of Tuberculosis Burden in Who Regions , Coun Tries of the World and the Russian Federation. Part 2. Tuberculosis Mortality

Vasilyeva, I. A.; Belilovsky, E. M.; Borisov, S. E.; Стерликов, С. А.

doi:10.21292/2078-5658-2017-95-7-8-16

Cited by 5 publications

(2 citation statements)

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“…Известно, что применение Перхлозона в составе комплексной терапии больных туберкулезом с МЛУ возбудителя достоверно увеличивает частоту прекращения бактериовыделения и закрытия каверн [3][4][5][6]. Однако остается нерешенным вопрос о безопасности применения препарата Перхлозон® у пациентов с туберкулезом и сопутствующей ВИЧ-инфекцией [7,8].…”

Section: Discussionunclassified

Safety assessment of the use of thioureidoiminomethylpyridinium perchlorate (Perchlozone) in the treatment of drug-resistant tuberculosis in patients with HIV infection

Shuvalova¹,

Panteleev²,

Daynovets³

et al. 2023

Infectious diseases: News, Opinions, Training

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РУБРИКА ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯFunding. The study had no sponsor support. Conflict of interest. The authors declare no conflict of interest. Contribution. The concept and design of the study, text editing -Panteleev A.M., Daynovets A.V.; collection and processing of material, writing the text, responsibility for the integrity of all parts of the article -Shuvalova E.V.; collection and processing of material, statistical data processing -Udaltsova E.V.; approval of the final version of the article -Panteleev A.M.

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Section: Discussionunclassified

Safety assessment of the use of thioureidoiminomethylpyridinium perchlorate (Perchlozone) in the treatment of drug-resistant tuberculosis in patients with HIV infection

Shuvalova¹,

Panteleev²,

Daynovets³

et al. 2023

Infectious diseases: News, Opinions, Training

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“…В настоящее время контроль за распространением туберкулеза все еще является одной из приоритетных задач мирового здравоохранения [1]. Развитие туберкулеза легких является сложным многокомпонентным процессом, включающим внешние (средовые) и внутренние (иммунные и генетические) факторы пациента и микробного агента [2].…”

Section: Introductionunclassified

Association of polymorphic variants of genes of xenobiotic biotransformation enzymes with susceptibility to pulmonary tuberculosis, taking into account gender features

Alymenko,

Valiev,

Valiev

et al. 2024

Sibirskij nauchnyj medicinskij zhurnal

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Aim of the study was to investigate susceptibility to pulmonary tuberculosis in men and women depending on polymorphism of genes of xenobiotic biotransformation enzymes NAT2 (590G> A (rs1799930)), CYP2E1 (9896C> G (rs2070676)), ABCB1 (3435T> C (rs1045642)), GSTM1 (E/D) and GSTT1 (E/D). Material and methods. The study included 335 patients with pulmonary tuberculosis aged 18 to 65 years (212 patients with newly diagnosed pulmonary tuberculosis and 123 people with chronic pulmonary tuberculosis receiving intensive phase of chemotherapy). Statistical data processing was carried out on a personal computer using IBM SPSS Statistics 26 and MS Excel 2013 software packages. The control group consisted of relatively healthy individuals without chronic diseases. Genotyping of polymorphisms NAT2 (590G>A (rs1799930)), CYP2E1 (9896C>G (rs2070676)), ABCB1 (3435T>C (rs1045642)) and extended deletions GSTM1 (E/D), GSTT1 (E/D) was performed using real time PCR. Results. It has been established that the genotype EЕ of GSTT1 gene identified in 89.1 % men was statistically significantly associated with increased susceptibility to pulmonary tuberculosis, while the genotype DD of the GSTT1 gene (10.9 % cases) was associated with reduced susceptibility. A similar trend is observed in women: the greatest susceptibility to pulmonary tuberculosis is characteristic for the genotype ЕЕ GSTT1 gene (87.2 %), the least (12.8 %) – for the DD genotype. Conclusions. It is advisable to introduce genotyping of genes of xenobiotic biotransformation enzymes into the practice of a phthisiologist in order to develop measures to improve the effectiveness of prevention and treatment of patients with pulmonary tuberculosis.

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Assessing efficiency of epidemiological security system for the medical organization

Степанова¹,

Rebeshchenko²,

Бакштановская³

et al. 2019

Russian Journal of Infection and Immunity

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Healthcare workers comprise a high-risk cohort of developing diverse infections caused by opportunistic and pathogenic microbes. Among medical workers of the Russian Federation the first rank place in occupational diseases is held by tuberculosis of respiratory organs accounting for more than half of all registered occupational diseases. Moreover, its high incidence is particularly noted among forensic specialists and medical workers in anti-tuberculosis institutions. The organization of epidemiological surveillance and tuberculosis prevention medical workers so far remains unsolved both scientifically and practically. On one hand, high TB incidence in pattern of clinical TB forms may be due to higher percentage of patients suffering from common, advanced and complicated forms of drug-resistant Mycobacterium tuberculosis infection as well as rise of socially significant co-infections (HIV+tuberculosis) among the population. Specialists from the Regional Bureau of Forensic Medicine were examined during 2009–2018 time period by using molecular genetic approaches to analyze 4948 wash samples (2009–2013 — 3649 samples; 2014–2018 — 1299 swabs) collected from various environmental objects, medical overalls and hands of medical specialists while performing professional duties in autopsy rooms, laboratories as well as facilities housekeeping department. It was demonstrated that M. tuberculosis DNA was detected in 353 and 81 swabs in 2009–2013 and 2014–2018 time period. Based on intensity of contacting with pathogenic biological agents, production technologies applied in the Regional Bureau of Forensic Medicine were divided into two groups. M. tuberculosis contamination in diverse facilities or any item as well as a contamination risk for medical worker hands and medical overalls were evaluated in accordance with professional duties assigned to individual specialists, followed by calculating significant differences in groups exami ned. It was found that some facilities and environmental items most exposed to a high-risk M. tuberculosis contamination were identified, which are involved in pathogen spreading from autopsy rooms outside to the remainder of facilities. It allowed for autho rities to improve performance of activities ensuring epidemiological security for attending specia lists that not only resulted in significantly decreased incidence of M. tuberculosis DNA detection, but also lowered TB incidence rate among them from 292.4 down to 280.9 cases and 46.3 per 10 thousand workers during 2007–2009 and 2017–2018 time period, respectively.

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Incidence, Mortality and Prevalence as Indicators of Tuberculosis Burden in Who Regions , Coun Tries of the World and the Russian Federation. Part 2. Tuberculosis Mortality

Cited by 5 publications

References 0 publications

Safety assessment of the use of thioureidoiminomethylpyridinium perchlorate (Perchlozone) in the treatment of drug-resistant tuberculosis in patients with HIV infection

Safety assessment of the use of thioureidoiminomethylpyridinium perchlorate (Perchlozone) in the treatment of drug-resistant tuberculosis in patients with HIV infection

Association of polymorphic variants of genes of xenobiotic biotransformation enzymes with susceptibility to pulmonary tuberculosis, taking into account gender features

Assessing efficiency of epidemiological security system for the medical organization

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