Incidence of acute respiratory distress syndrome and its relation to age

Manzano, Francisco; Yuste, E; Colmenero, Manuel; Aranda, Agustı́n; García-Horcajadas, Antonio; Rivera, Ricardo; Mondéjar, E. Fernández

doi:10.1016/j.jcrc.2005.05.008

Cited by 45 publications

(27 citation statements)

References 36 publications

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“…Even among severe ARDS, diagnosis was missed in at least one patient out of 5. These results are in line with another study that estimated ARDS under-recognition by clinicians in up to 50% of cases, despite the accepted use of AECC definition and staff training (55). In LUNG SAFE, organizational and patient factors were reported to be associated with higher clinician recognition of ARDS in invasively ventilated patients.…”

Section: Ards Incidence-an Underestimated Syndromesupporting

confidence: 89%

“…Furthermore, in countries of the same continent such as Europe, ARDS occurrence varies consistently, ranging from 10.6 per 100,000 person-years in Finland (82), to 17.9 per 100,000 person-years in Scandinavia (79), to 25.5 per 100,000 person-years in Spain (55). This is the case also for hospitalization based studies (77), which showed a ARDS proportion ranging from 7.1% (83) to 12.5% (84) of incidence proportion of all ICU admissions in Europe to 19% in 14 ICUs of Ireland (85), among the admitted patients ( Table 2).…”

Section: Ards Incidence-an Underestimated Syndromementioning

confidence: 99%

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Definition and epidemiology of acute respiratory distress syndrome

Rezoagli¹,

Fumagalli²,

Bellani³

2017

Ann. Transl. Med.

178

127

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Fifty years ago, Ashbaugh and colleagues defined for the first time the acute respiratory distress syndrome (ARDS), one among the most challenging clinical condition of the critical care medicine. The scientific community worked over the years to generate a unified definition of ARDS, which saw its revisited version in the Berlin definition, in 2014. Epidemiologic information about ARDS is limited in the era of the new Berlin definition, and wide differences are reported among countries all over the world. Despite decades of study in the field of lung injury, ARDS is still so far under-recognized, with 2 out of 5 cases missed by clinicians. Furthermore, although advances of ventilator strategies in the management of ARDS associated with outcome improvements-such as protective mechanical ventilation, lower driving pressure, higher PEEP levels and prone positioning-ARDS appears to be undertreated and mortality remains elevated up to 40%. In this review, we cover the history that led to the current worldwide accepted Berlin definition of ARDS and we summarize the recent data regarding ARDS epidemiology.

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Section: Ards Incidence-an Underestimated Syndromesupporting

confidence: 89%

Section: Ards Incidence-an Underestimated Syndromementioning

confidence: 99%

Definition and epidemiology of acute respiratory distress syndrome

Rezoagli¹,

Fumagalli²,

Bellani³

2017

Ann. Transl. Med.

178

127

View full text Add to dashboard Cite

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“…The relationship between age and increased incidence of and mortality from acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) has been established in both humans and animal models (Manzano et al 2005; Prows et al 2015; Rubenfeld et al 2005). Increasing evidence suggests that neuromuscular weakness developing from critical illness is independently associated with morbidity and mortality, and is therefore an attractive therapeutic target (Ali et al 2008; Hermans et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism

et al. 2016

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Introduction Older patients are more likely to acquire and die from acute respiratory distress syndrome (ARDS) and muscle weakness may be more clinically significant in older persons. Recent data implicate muscle ring finger protein 1 (MuRF1) in lung injury-induced skeletal muscle atrophy in young mice and identify an alternative role for MuRF1 in cardiac metabolism regulation through inhibition of fatty acid oxidation. Objectives To develop a model of lung injury-induced muscle wasting in old mice and to evaluate the skeletal muscle metabolomic profile of adult and old acute lung injury (ALI) mice. Methods Young (2 month), adult (6 month) and old (20 month) male C57Bl6J mice underwent Sham (intratracheal H2O) or ALI [intratracheal E. coli lipopolysaccharide (i.t. LPS)] conditions and muscle functional testing. Metabolomic analysis on gastrocnemius muscle was performed using gas chromatography-mass spectrometry (GC-MS). Results Old ALI mice had increased mortality and failed to recover skeletal muscle function compared to adult ALI mice. Muscle MuRF1 expression was increased in old ALI mice at day 3. Non-targeted muscle metabolomics revealed alterations in amino acid biosynthesis and fatty acid metabolism in old ALI mice. Targeted metabolomics of fatty acid intermediates (acyl-carnitines) and amino acids revealed a reduction in long chain acyl-carnitines in old ALI mice. Conclusion This study demonstrates age-associated susceptibility to ALI-induced muscle wasting which parallels a metabolomic profile suggestive of altered muscle fatty acid metabolism. MuRF1 activation may contribute to both atrophy and impaired fatty acid oxidation, which may synergistically impair muscle function in old ALI mice.

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“…Studies examining the population incidence of ARDS using the AECC criteria for diagnosis of ARDS from various countries demonstrate a wide variation in the incidence of ARDS ranging from 6 to 79 cases of ARDS per 100,000 persons per year (►Table 3). 23,24,[26][27][28][34][35][36][37][38][39] These general population estimates place ARDS incidence at or near the cusp of what is generally considered a rare disease by the United States and European Union. 40 In contrast, studies of ICU incidence and prevalence demonstrate that within the ICU setting, ARDS is common.…”

Section: Incidence and Prevalence Of Ardsmentioning

confidence: 99%

Definitions, Epidemiology, Clinical Risk Factors, and Health Disparities in Acute Respiratory Distress Syndrome

Kang

Kempker

2019

Semin Respir Crit Care Med

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Acute respiratory distress syndrome (ARDS) is a syndrome of inflammatory lung injury currently defined as the rapid onset of hypoxemia and radiographic opacities from a recent direct or indirect insult that is not explained by other causes. While the diagnostic criteria used to define ARDS are helpful in the clinical setting, they are not entirely specific for the characteristic pathophysiology of diffuse alveolar lung damage. This case definition introduces challenges to the reliable and accurate epidemiologic study of the condition. Within these limitations, ARDS appears to be a condition that is relatively rare within the general population but common within the context of the intensive care unit. Furthermore, the frequency and outcomes of ARDS seem to vary between populations, with no clearly discernible temporal trends in incidence or case fatality that are uniform across studies.

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Incidence of acute respiratory distress syndrome and its relation to age

Cited by 45 publications

References 36 publications

Definition and epidemiology of acute respiratory distress syndrome

Definition and epidemiology of acute respiratory distress syndrome

Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism

Definitions, Epidemiology, Clinical Risk Factors, and Health Disparities in Acute Respiratory Distress Syndrome

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