Incidence of AIDS-Defining Cancers After AIDS Diagnosis Among People with AIDS in Italy, 1986–1998

Franceschi, Silvia; Maso, Luigino Dal; Pezzotti, Patrizio; Polesel, Jerry; Braga, Cláudia; Piselli, Pierluca; Serraino, Diego; Tagliabue, Giovanna; Federico, Massimo; Ferretti, Stefano; Lisi, Vincenzo De; Rosa, Francesco La; Conti, Ettore; Budroni, Mario; Vicario, Gianni; Piffer, Silvano; Pannelli, F; Giacomin, Adriano; Bellù, Francesco; Tumino, Rosario; Fusco, Mario; Rezza, Giovanni

doi:10.1097/00126334-200309010-00013

Cited by 50 publications

(29 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results were obtained after stratifying according to the latest viral load (≤ or > 50 copies/mL) rather than HAART status (data not shown). Our data show that the incidence of systemic NHL has declined over the HAART era, extending the observations in previous publications; [5][6][7][8][9][10][11][12] the continuing decline in incidence may explain some of the differences between this dataset and the recently published Swiss cohort findings. 13 Several studies have found that HAART reduces the incidence of NHL.…”

Section: Development Of Lymphoma Nsupporting

confidence: 88%

CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK

Bower

Fisher²,

Hill³

et al. 2009

Haematologica

View full text Add to dashboard Cite

Section: Development Of Lymphoma Nsupporting

confidence: 88%

CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK

Bower

Fisher²,

Hill³

et al. 2009

Haematologica

View full text Add to dashboard Cite

“…[1][2][3][4][5][6][7][8][9][10][11] Risks relative to the general population are increased from 5-to 15-fold. Additionally, most HL cases in PWHAs are mixed cellularity (MC) and lymphocyte-depleted (LD) subtypes, whereas the nodular sclerosing (NS) subtype predominates in young adults without HIV/AIDS.…”

Section: Introductionmentioning

confidence: 99%

Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS

Biggar

Jaffe²,

Goedert³

et al. 2006

Blood

413

295

View full text Add to dashboard Cite

In persons with HIV/AIDS (PWHAs), Hodgkin lymphoma (HL) risk is increased. However, HL incidence in PWHAs has unexpectedly increased since highly active antiretroviral therapy (HAART) was introduced. We linked nationwide HIV/AIDS and cancer registry data from 1980 through 2002. Immunity was assessed by CD4 T-lymphocyte counts at AIDS onset. Annual HL incidence rates were calculated for 4 through 27 months after AIDS onset. IntroductionHodgkin lymphoma (HL) risk is significantly increased in persons with HIV/AIDS (PWHAs) of all ages. [1][2][3][4][5][6][7][8][9][10][11] Risks relative to the general population are increased from 5-to 15-fold. Additionally, most HL cases in PWHAs are mixed cellularity (MC) and lymphocyte-depleted (LD) subtypes, whereas the nodular sclerosing (NS) subtype predominates in young adults without HIV/AIDS. 2,12,13 That HIV/AIDS-related immunosuppression would affect HL risk and subtype distribution is not surprising. Persons with genetic conditions associated with T-lymphocyte immune dysfunction have a higher risk of HL, and patients with HL may have underlying abnormalities of T-cell immunity. 14 Few studies of HL in PWHAs have had sufficient data to examine risks in the era of highly active antiretroviral therapy (HAART). By controlling HIV replication with combination therapies, HAART improves immune function, and its use is associated with reduced incidence of Kaposi sarcoma and non-Hodgkin lymphoma (NHL), the 2 most common AIDSassociated cancers. [15][16][17][18] Unexpectedly, however, HL risk in PWHAs increased after HAART became available in 1996. 15,18 Consistent with this temporal increase, HL incidence was reported to be higher in HIV-infected persons using HAART than in those not using it. 16 To address the role of immunity in HL etiology, we examined HL risk in a large multicenter study linking HIV/AIDS and cancer registry data. Since 1990, CD4 T-lymphocyte counts have been increasingly recorded by HIV/AIDS registries, permitting prospective studies of HL incidence using this marker of immune status to stratify subjects. We also examined the relationship between CD4 count and the incidence of specific HL subtypes provided by the cancer registries. Patients, materials, and methodsSince 1991, we have periodically linked HIV/AIDS and cancer registry data in the United States. The current linkage included the states of Connecticut, Georgia, Florida, Massachusetts, Michigan, and New Jersey, and the metropolitan areas of Los Angeles, San Diego, and San Francisco, CA; New York City, NY; and Seattle, WA. We included HIV/AIDS cases registered through 2002 and linked them to cancer diagnoses during periods when cancer registry data were considered complete. Details of the matching approach have been presented elsewhere. 6,9,11,19 Briefly, a probabilistic algorithm identified record linkages using the social security number, name, sex, race, and birth and death dates. Possible linkages were reviewed by authorized registry personnel to ensure their validity, and questionable linkages we...

show abstract

“…Kaposi's sarcoma (KS)-associated herpesvirus (KSHV or human herpesvirus 8) is a member of the gamma (lymphotropic) subfamily of herpesviruses and is responsible for several distinct human diseases, including KS, primary effusion lymphoma, and multicentric Castleman's disease (8,13,28,41). While pathologically diverse, these disorders are all primarily associated with an immunocompromised state, and thus, KSHV infection poses a significant threat to human immunodeficiency virus type 1-infected individuals and solid organ transplant recipients worldwide.…”

mentioning

confidence: 99%

Intracellular Kaposi's Sarcoma-Associated Herpesvirus Load Determines Early Loss of Immune Synapse Components

Adang¹,

Tomescu²,

Law³

et al. 2007

J Virol

View full text Add to dashboard Cite

Lifelong infection is a hallmark of all herpesviruses, and their survival depends on countering host immune defenses. The human gammaherpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV) encodes an array of proteins that contribute to immune evasion, including modulator of immune recognition 2 (MIR2), an E3 ubiquitin ligase. Exogenously expressed MIR2 downregulates the surface expression of several immune synapse proteins, including major histocompatibility complex (MHC) class 1, ICAM-1 (CD54), and PECAM (CD31). Although immunofluorescence assays detect this lytic gene in only 1 to 5% of cells within infected cultures, we have found that de novo infection of naive cells leads to the downregulation of these immune synapse components in a major proportion of the population. Investigating the possibility that low levels of MIR2 are responsible for this downregulation in the context of viral infection, we found that MIR2 transduction recapitulated the patterns of surface downregulation following de novo infection and that both MIR2 promoter activation, MIR2 expression level, and immune synapse component downregulation were proportional to the concentration of KSHV added to the culture. Additionally, MIR2-specific small interfering RNA reversed the downregulation effects. Finally, using a sensitive, high-throughput assay to detect levels of the virus in individual cells, we also observed that downregulation of MHC class I and ICAM-1 correlated with intracellular viral load. Together, these results suggest that the effects of MIR2 are gene dosage dependent and that low levels of this viral protein contribute to the widespread downregulation of immune-modulating cell surface proteins during the initial stages of KSHV infection.

show abstract

Incidence of AIDS-Defining Cancers After AIDS Diagnosis Among People with AIDS in Italy, 1986–1998

Cited by 50 publications

References 38 publications

CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK

CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK

Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS

Intracellular Kaposi's Sarcoma-Associated Herpesvirus Load Determines Early Loss of Immune Synapse Components

Contact Info

Product

Resources

About