Incidence of analgesic nephropathy in Berlin since 1983

Schwarz, Anke; Preuschof, Lothar; Zellner, Dietmar

doi:10.1093/ndt/14.1.109

Cited by 11 publications

(5 citation statements)

References 5 publications

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“…13 [59] None [49,50], no data; see Table S1 Stewart 1978 Kidney Int. Schwarz et al [97] did not mention caffeine as a promoter of analgesic overuse, but they claimed the ban on caffeine-containing combination analgesics, which was criticized by Fox [98] because of the lack of evidence for such claim. Schwarz et al [97] did not mention caffeine as a promoter of analgesic overuse, but they claimed the ban on caffeine-containing combination analgesics, which was criticized by Fox [98] because of the lack of evidence for such claim.…”

Section: Discussionmentioning

confidence: 99%

“…Year [19] constitutes an indicator of a high risk of dependence' is invalid [26]. Schwarz et al [97] did not mention caffeine as a promoter of analgesic overuse, but they claimed the ban on caffeine-containing combination analgesics, which was criticized by Fox [98] because of the lack of evidence for such claim. The reply of Schwarz [99] did not reveal any further information.…”

Section: Authormentioning

confidence: 99%

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Caffeine as a promoter of analgesic‐associated nephropathy – where is the evidence?

Fox

Siebers²

2003

Fundamemntal Clinical Pharma

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Individual groups of nephrologists - in their responsibility for their patients - initiated a most controversial discussion whether or not caffeine - coformulated to analgesics - might initiate or sustain analgesic overdosing. The original sources (data) of such suspicion have got lost during the debate of the last two decades. Therefore, it seemed to be appropriate to investigate the original data background and the reasons why nephrologists started to suspect caffeine as a stimulant of analgesic overdosing by employing a systematic and exhaustive review of primary nephrological publications. Their selection followed a precise selection plan, including all epidemiological studies on analgesic-associated nephropathy, the original papers of all groups having been involved in those studies, further originals from the mainly involved countries (academically, politically), and any literature thereof cited as a proof. The following results emerged from the investigation: (i) The epidemiological studies warranted no conclusion about a role of caffeine in prompting excessive analgesic use. (ii) The identified groups of nephrologists provided not substantial data to advocate the said suspicion, except for the observation of a preferential choice of phenacetin-containing combinations, especially powder preparations. (iii) Only two cited original data sources revealed drug-seeking behaviour with phenacetin-containing preparations which subsided, after phenacetin was banned from the respective markets. Conclusively, it appears that there is no substantial data to support a pivotal role of caffeine in initiating or sustaining analgesic overdosing. However, there is strong data that phenacetin, by its psychotropic properties, may have caused drug-seeking behaviour and thus led to analgesic overdosing. This conclusion is convincingly supported by thorough pharmacokinetic investigations. Note: All caffeine-related statements within the reviewed literature have been collected in tables (referred to as Table SX) which are provided in full text for check on the following website: http://www.blackwellpublishing.com/products/journals/suppmat/FCP/FCP174/FCP174sm.htm

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Section: Discussionmentioning

confidence: 99%

Section: Authormentioning

confidence: 99%

Caffeine as a promoter of analgesic‐associated nephropathy – where is the evidence?

Fox

Siebers²

2003

Fundamemntal Clinical Pharma

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“…Dieser hohe prozentuale Diabetikeranteil weicht auch erheblich von dem von QuaSi-Niere überregional festgestellten Prozentsatz ab und lässt eine Patientenselektion vermuten [25]. Die vorliegenden Ergebnisse, wie die QuaSi-Niere-Befunde, widersprechen zudem Schwarz et al [24], die bei 212 Neuzugängen zur Dialyse zwischen 1982 und 1997 einen Diabetikeranteil von 7-29% feststellten; auch diese relativ kleine Stichprobe ist mög-licherweise für die tatsächlichen Verhält-nisse in Deutschland nicht repräsentativ. Die von Lippert et al [14] veröffentlich-te Stichprobe war ebenfalls zu klein, um Generalisierungen zu erlauben: Sie umfasste insgesamt nur 225 Patienten, darunter 95 Diabetiker, die während 18 Monaten als Dialyse-Neuzugänge verzeichnet wurden.…”

Section: Has the Incidence Of End-stage Renal Disease Increased In DIunclassified

“…Wie alle früheren Stichprobenstudien in Deutschland [14,24,25] ist auch sie keine Populationsstudie, sondern nur eine Zentrumsstudie mit den sich daraus ergebenden Möglich-keiten des Selektionsbias. Auch ist sie -wie die früheren Studien -eine retrospektive Studie mit der sich daraus ergebenden Heterogenität der Befundqualität.…”

Section: Has the Incidence Of End-stage Renal Disease Increased In DIunclassified

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Hat die Inzidenz der dialysepflichtigen Niereninsuffizienz bei Diabetikern zugenommen?

Landeghem

2005

Med Klin

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The incidence of patients with end-stage renal disease entering hemodialysis has not changed between 1990 and 1999, and the proportion of diabetic patients has remained the same. However, the patients' age at entering hemodialysis has increased significantly between 1990 and 1999. As the documentation in the patients' records was unsatisfactory with regard to diabetes history and causes for dialysis, the results of the present study need to be interpreted with caution.

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Selbstmedikation bei Migräne und Kopfschmerz vom Spannungstyp

Göbel¹

2012

Die Kopfschmerzen

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Incidence of analgesic nephropathy in Berlin since 1983

Cited by 11 publications

References 5 publications

Caffeine as a promoter of analgesic‐associated nephropathy – where is the evidence?

Caffeine as a promoter of analgesic‐associated nephropathy – where is the evidence?

Hat die Inzidenz der dialysepflichtigen Niereninsuffizienz bei Diabetikern zugenommen?

Selbstmedikation bei Migräne und Kopfschmerz vom Spannungstyp

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