Incidence of and factors associated with metabolic syndrome, south-east Islamic Republic of Iran

Farmanfarma, Khadijeh Kalan; Ansari‐Moghaddam, Alireza; Kaykhaei, Mahmoud Ali; Mohammadi, Mehdi; Adineh, Hosein Ali; Aliabd, Hasan

doi:10.26719/emhj.21.051

Cited by 9 publications

(10 citation statements)

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“…FBG > 100 mg/dl was associated with about 3% increased risk of MetS. Consistent with our nding, same signi cant contribution of FBG in MetS development was found in a recent study recruiting Iranian participants [23].…”

Section: Discussionsupporting

confidence: 92%

“…Consistent with our evidence, a recent cohort study recruiting 2,935 middle-aged Chinese population with 3-year follow-up showed the higher risk of MetS incidence in participants having higher BP in compare to normotensive group (hazard ratio (HR), 1.823; 95% CI, 1.538-2.162) [22]. With respect of the signi cant association between TG and metabolic disorders in our study, investigating the population in south of Iran demonstrated the notable linkage between high TG and MetS burden [23].…”

Section: Discussionmentioning

confidence: 51%

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Non-HDL cholesterol and long-term follow-up of metabolic syndrome outcome

Vazirian

Darroudi

Rahimi

et al. 2023

Preprint

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Background Non-high-density lipoprotein-cholesterol (non-HDL-C) has been identified as a potential biomarker for metabolic syndrome (MetS). However, its predictive capability for MetS varies among different ethnic groups, indicating the need for further clarification. This study aimed to investigate the potential role of non-HDL-C in the early diagnosis of MetS in the Iranian population using a longitudinal study with a 10-year follow-up period.Methods Our study included 4684 individuals from the MASHAD (Mashhad Stroke and Heart Atherosclerotic Disorder) cohort, followed for 10 years to investigate the association between non-HDL-C and the incidence of MetS. We also assessed the contribution of individual components of MetS to the overall burden.Results Out of 7561 individuals, who completed 10-years follow-up, 3085 subjects developed MetS. Non-HDL-C levels ≥ 130 had a 28% higher risk of developing MetS (relative risk (RR),1.27; 95% confidence interval (CI), 1.14–1.41). Elevated waist circumference (WC) had the strongest association with MetS incidence (RR,1.51; 95% CI, 1.45–1.58), whereas triglyceride (TG) levels ≥ 150 mg/dl demonstrated the weakest association (RR,1.07; 95% CI, 1.01–1.15). Fasting blood glucose (FBG) levels ≥ 100 mg/dl were not significantly linked to MetS burden. Conversely, higher HDL-C levels show protective effect against the risk of MetS (RR, 0.87; 95% CI: 0.76-1.00), while blood pressure (BP) levels ≥ 130 mmHg or diastolic BP levels ≥ 85 mmHg increased the risk of MetS incidence (RR, 1.081; 95% CI: 1.037–1.127).Conclusions Elevated non-HDL-C and increased WC are significant predictors of MetS in our population. To reduce the risk of MetS development, strategies targeting non-HDL-C levels and weight loss should be emphasized.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 51%

Non-HDL cholesterol and long-term follow-up of metabolic syndrome outcome

Vazirian

Darroudi

Rahimi

et al. 2023

Preprint

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“…According to Figure 1 , the diagnostic criteria for people with MetS were a large wc (94.30%), lowered HDL (80.20%), high blood pressure (71.70%), and elevated blood glucose (69.60%), while elevated triglyceride (40.50%) had the lowest proportion. These results were in conflict with those of this study done by Farmanfarma et al ., 25 which demonstrated that the most common diagnostic criteria for MetS were increased wc and high blood pressure, while lowered HDL was the least common. Furthermore, these findings are consistent with those of another study by Venugopal et al , 26 which indicated that a large wc and low HDL are the most common MetS diagnostic criteria, while elevated blood sugar and high triglyceride are the least common.…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome distribution based on diagnostic criteria and family history among adults in Al-Basra, Iraq

Maatook

Zaboon

2023

J. Public Health Afr.

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Background. Metabolic syndrome (MetS) is a collection of cardiovascular risk factors induced by insulin resistance and an inflammatory state that increases the likelihood of developing type 2 diabetes and a variety of cardiovascular disorders. Objective. The study aims to determine the distribution of MetS by diagnostic criteria and family history among adults in Al-Basra province, southern Iraq. Methods. A cross-sectional study was conducted at the Al-Fiaha Specialized Diabetes, Endocrine, and Metabolism Center (FDEMC) from October 2nd, 2022, to May 1st, 2023. Following ethical approval, data was obtained using a pre-tested questionnaire. All patient information was obtained from direct interviews as well as FDEMC's digital records, which controlled patient data via a Microsoft Access program and an internal network. Results. This study included 476 people, aged 19 to 89. The sample had an equal number of males and females (238). MetS was identified in 247 people in the entire sample using International Diabetes Federation criteria. The proportion of participants with family history was as follows: obesity (30.0%), hypertension (44.1%), diabetes mellitus (46.6%), and cardiovascular disease (9.3%). The diagnostic criteria for MetS were as follows: high waist circumference (94.3%), elevated glucose (69.6%), reduced HDL (80.2%), elevated TG (40.5%), and hypertension (71.7%). Controlled on glycemic status (21.1%), hypertension (61.9%), and lipids (44.1%). Conclusion. Large waist circumference, reduced HDL, and family histories of obesity, hypertension, diabetes mellitus, or cardiovascular disease are the most important risk factors for MetS. Participants with MetS have difficulties controlling their blood sugar, but they regulate the other MetS components.

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“…In various parts of the world, the incidence of metabolic syndrome (MetS) has been estimated to range from 28 per 1000 people per year to more than 70 per 1000 people per year. Rapid economic development, the rise in popularity of the Western lifestyle, and a lack of physical activity have all contributed to the obesity and type 2 diabetes mellitus (T2DM) epidemics that threaten to spread worldwide ( 2 ). Globally, the prevalence of MetS is rising at an alarming rate and is more common among T2DM patients.…”

Section: Introductionmentioning

confidence: 99%

CRP/HDL–C and Monocyte/HDL-C ratios as Predictors of Metabolic Syndrome in Patients With Type 2 Diabetes Mellitus

Djesevic,

Hasic,

Lepara

et al. 2023

Acta Inform Med

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Background: Metabolic syndrome (MetS) denotes a cluster of co-occurring medical conditions associated with regulating hyperglycemia and acute cardiovascular events and complications. The escalating frequency of MetS among individuals afflicted with type 2 diabetes mellitus (T2DM) underscores its burgeoning significance as a critical public health concern and a complex clinical conundrum. Timely identification is imperative to avert the expedited progression of diabetic complications. Objective: To investigate the role of CRP/HDL-C and Monocyte/HDL ratios in predicting MetS in T2DM individuals. Methods: The study was designed as a two-year prospective study and included 80 T2DM patients divided into MetS and non-MetS groups based on MetS development over two years. The patients’ serums were analyzed for complete blood count parameters, lipid profile, and C-reactive protein (CRP). Based on the laboratory test results, Monocyte/HDL-C and CRP/HDL-C ratios were calculated and analyzed. The receiver operating characteristic (ROC) curve and their corresponding areas under the curve (AUC) were used to determine prognostic accuracy. Results: Monocyte/HDL-C ratio and CRP/HDL-C ratio were significantly higher in MetS-T2DM2 than in nonMetS-T2DM (p=0.003 and p=0.029, respectively). The results of ROC curve analysis have shown that the CRP/HDL-C ratio (AUC of 0.695) and Monocytes/HDL-C ratio (AUC of 0.645) can serve as good predictors of MetS in T2DM patients. Conclusion: This study confirms the reliability of the Monocytes/HDL-C and CRP/HDL-C ratios as novel, simple, low-cost, and valuable predictors of MetS development in T2DM.

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Incidence of and factors associated with metabolic syndrome, south-east Islamic Republic of Iran

Cited by 9 publications

References 0 publications

Non-HDL cholesterol and long-term follow-up of metabolic syndrome outcome

Non-HDL cholesterol and long-term follow-up of metabolic syndrome outcome

Metabolic syndrome distribution based on diagnostic criteria and family history among adults in Al-Basra, Iraq

CRP/HDL–C and Monocyte/HDL-C ratios as Predictors of Metabolic Syndrome in Patients With Type 2 Diabetes Mellitus

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