Incidence of Autoimmune Antibodies in Failed Embryo Transfer Cycles

Abstract

Patients receiving ET are carrying viable embryos within the intrauterine environment. Therefore, in this unique group of patients, failure to demonstrate a positive pregnancy test represents an implantation failure or a very early postimplantation loss. The results of this study suggest that periimplantation events may be affected by autoimmune antibodies. Very early miscarriage or implantation failure may be related to the same pathophysiological mechanism that causes recurrent miscarriages and is diagnosed incorrectly as infertility.

Evaluation of anticardiolipin antibodies and antiphosphatidylserine antibodies in women with recurrent abortion

“…These miscarriages or implantation failure may be related to pathological mechanism causing recurrent abortion, which is commonly diagnosed as infertility. [3] There is clear documentation that aCL are involved in fetal wastages and recurrent abortion irrespective of the patient whether having auto immune disease or not. Anticardiolipin antibody detection may be the most sensitive method in prevention of fetal wastage.…”

The Means of Progress in Improving the Results of in vitro Fertilization Based on the Identification and Correction of the Pathology of Hemostasis

“…Besides, a number of researchers raise a great interest in the decrease of fibrinolytic blood activity, which is often detected in recurrent miscarriages, APS, deep vein thrombosis of lower extremities, oral contraceptive intake, myocardial infarction, and malignant neoplasms (Bertina, 1997;Birkenfeld et al, 1994;Curnow et al, 2006;Dmowski et al, 1995;Egbase et al, 1999;Lisman et al, 2005;Meltzer et al, 2009;Meltzer et al, 2010;Triplett, 1989;Wichers et al, 2009). The system of fibrinolysis, as well as the system of coagulation, is a complex system which gives characteristics to fibrinolytic responses and its central element that plays role in the activation of plasminogen into plasmin.…”

Obstetrical Considerations and Management of Antiphospholipid Syndrome

“…However, aPL were not associated with mild preeclampsia [23]. The second meta-analysis evaluated all three aPL and the adverse pregnancy outcomes of pre-eclampsia, fetal growth restriction, placental abruption, and stillbirth [24]. They found LAC and aCL to be more common in preeclampsia in 10 case-control studies but not in three cohort studies.…”