Incidence of biopsy-proven primary glomerulonephritis in an Italian Province

Stratta, Piero; Segoloni, Giuseppe; Canavese, Caterina; Sandri, L; Mazzucco, Gianna; Roccatello, Dario; Manganaro, Marco; Vercellone, A

doi:10.1016/s0272-6386(96)90096-7

Cited by 73 publications

(60 citation statements)

References 7 publications

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“…When we consider the results of all renal biopsies in Spain during the same period, we see that crescentic GN and vasculitis take sixth place (6.8%), preceded by IgA nephropathy (14.5%), membranous nephropathy (10.6%), FSGS (9.4%), lupus nephritis (9.2%), and minimal-change disease (7.4) (1,2). In the Italian registry, there was an increase in the percentage of patients who were older than 65 yr and required renal biopsy (40). These findings highlight the role of crescentic proliferation in the acute deterioration of renal failure; however, it is widely known that pauci-immune crescentic GN is a form of renal limited vasculitis generally associated with ANCA.…”

Section: Discussionmentioning

confidence: 98%

Renal Biopsy Findings in Acute Renal Failure in the Cohort of Patients in the Spanish Registry of Glomerulonephritis

López‐Gómez¹,

Rivera²

2008

Clinical Journal of the American Society of Nephrology

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Section: Discussionmentioning

confidence: 98%

Renal Biopsy Findings in Acute Renal Failure in the Cohort of Patients in the Spanish Registry of Glomerulonephritis

López‐Gómez¹,

Rivera²

2008

Clinical Journal of the American Society of Nephrology

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“…20 The prevalence of glomerular diseases presents high variability between different parts of the world. [3][4][5][6]14,[19][20][21][22][23] The majority of studies have found that idiopathic focal segmental glomerulosclerosis is the most common glomerular disease in adults. 6,20,24 The reason for the variability in the prevalence of these diseases around the world remains unclear, but it is known that ethnic, socioeconomic and geographical factors may explain this.…”

Section: Prevalence and Classification Of Glomerular Diseasesmentioning

confidence: 99%

Pattern, clinical features and response to corticoids of glomerular diseases in a Brazilian population. An analytical cross-sectional study

et al. 2014

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CONTEXT AND OBJECTIVE: Glomerular disease registries are increasing all around the world. The aim of this study was to evaluate the clinical characteristics and treatment response among patients with glomerular diseases followed up in a tertiary hospital in Brazil. DESIGN AND SETTING: Analytical cross-sectional study; tertiary-level public hospital. METHODS:This study included patients with glomerular diseases followed up at a tertiary hospital in Fortaleza, northeastern Brazil. Clinical and laboratory data on each patient were registered. The response to specific treatment was evaluated after 3, 6 and 12 months. RESULTS:The study included 168 patients of mean age 37 ± 14 years. The main clinical presentations were nephrotic proteinuria (67.3%) and renal insufficiency (17.9%). The mean proteinuria value decreased after the treatment began. Regarding 24-hour proteinuria on admission, there was no significant difference between patients with a good response and those with no response (7,448 ± 5,056 versus 6,448 ± 4,251 mg/24 h, P = 0.29). The glomerular disease with the highest remission rate was MCD (92%). Absence of interstitial fibrosis presented a strong correlation with remission (remission in patients without fibrosis = 83.4% versus 16.3% in those with fibrosis, P = 0.001).CONCLUSIONS: The present study found that the most frequent glomerular disease was FSGS, followed by MCD, MN and LN. The presence of interstitial fibrosis was a predictor of poor therapeutic response. Com relação à proteinúria de 24 horas na admissão, não houve diferença significativa entre os pacientes com boa resposta ao tratamento e aqueles sem resposta (7.448 ± 5.056 versus 6.448 ± 4.251 mg/24 h, P = 0,29). A doença com maior índice de remissão foi a DLM (92%). A ausência de fibrose intersticial apresentou forte correlação com a remissão (remissão em pacientes sem fibrose = 83,4% versus 16,3% naqueles com fibrose, P = 0,001). CONCLUSÕES: O presente estudo encontrou como glomerulopatia mais frequente a GESF, seguida da DLM, NM e NL. A presença de fibrose intersticial foi um preditor de pobre resposta terapêutica. RESUMO

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“…Enteroviruses are established or suspected etiological agents in numerous diseases. In particular, group B coxsackie viruses (CBs), which are enteroviruses, have been implicated in several diseases, including pancreatitis, insulin-dependent diabetes mellitus, myocarditis, and myositis [3][4][5][6]. They have also been reported to be etiological agents in some renal diseases.…”

Section: Viral Infection and Kidney Injurymentioning

confidence: 99%

“…Patients harbor circulating immune complexes composed of IgA, complement components, fibronectin, and collagen 1 ,2). As a result of the requirement of a renal biopsy for correct diagnosis, the true incidence is not known 3 ). Although IgAN is prevalent in all ethnic groups, Japan and Korea have some of the highest recorded incidence.…”

Section: Introductionmentioning

confidence: 99%

Pathogenesis and Treatment in IgA Nephropathy

Tomino¹

2016

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IgA nephropathy (IgAN) is one of the most common causes of glomerulonephritis in the world. The proliferative and crescentic forms of IgA are found in up to 30% of cases and are associated with nephritic-range proteinuria, accelerated hypertension, and accelerated decline toward ESRD. Thus, it is important to investigate the mechanism of the onset of IgAN and to identify the most appropriate treatment. We herein review the pathogenesis and treatment of IgA nephropathy. As to the pathogenesis, we found that CB4 provoked exacerbation of renal pathologic findings in RIGA mice via endothelial injury, IFN -gamma production, and dysfunction of the mesangial pathway and could possibly become one of the factors involved in the mechanism of the onset or evolution of human IgAN. As to the treatment of IgAN, we evaluated the efficacy of tonsillectomy plus prednisolone, warfarin, and dipyridamole including methylprednisolone pulse therapy (tonsillectomy plus pulse therapy) and prednisolone, warfarin, and dipyridamole including mizoribine (PWDM) for the treatment of diffuse IgAN in children. These therapies were effective in ameliorating the proteinuria and histological severity of patients with IgAN. Furthermore the detail investigations into the pathogenesis of IgAN and double-blind randomized control studies on children with IgAN will be necessary.

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Incidence of biopsy-proven primary glomerulonephritis in an Italian Province

Cited by 73 publications

References 7 publications

Renal Biopsy Findings in Acute Renal Failure in the Cohort of Patients in the Spanish Registry of Glomerulonephritis

Renal Biopsy Findings in Acute Renal Failure in the Cohort of Patients in the Spanish Registry of Glomerulonephritis

Pattern, clinical features and response to corticoids of glomerular diseases in a Brazilian population. An analytical cross-sectional study

Pathogenesis and Treatment in IgA Nephropathy

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