Incidence of bone metastasis and factors contributing to its development and prognosis in newly diagnosed renal cell carcinoma: a population-based study

Guo, Qi; Zhang, Chao; Guo, Xu; Fang, Tao; Xu, Yao; Feng, Guowei; Han, Xiuxin; Ren, Zhiwu; Zhang, Hui; Zhang, Pingfang; Wang, Xin; Wang, Guowen

doi:10.2147/cmar.s170083

Cited by 31 publications

(33 citation statements)

References 15 publications

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“…Prognostic factors in the cancer patients with distant metastases have been widely studied [14][15][16].…”

Section: Ivyspringmentioning

confidence: 99%

Prognosis for different patterns of distant metastases in patients with uterine cervical cancer: a population-based analysis

Zhang¹,

Guo²,

Zhou³

et al. 2020

J. Cancer

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Background: Uterine cervical cancer (UCC) is a common malignant tumor in women. We conducted this work to provide a though description on the patterns of distant metastases and to investigate the relevant factors for prognosis of UCC patients based on a large population. Patients and methods: UCC patients with FIGO stage IVB, being the study group, were identified from the Surveillance, Epidemiology, and End Result (SEER) database from 2010 to 2016. UCC patients with same inclusion criteria, being validation group, were identified from Tianjin First Central Hospital from 2004 to 2017. Patterns of distant metastases were described according to the number of metastatic sites. Survival of different patterns were calculated and prognostic factors were investigated by Cox hazard regression analysis. Results: Distant metastases were recorded in 1448 UCC patients among whom 295 patients (30.8%) developed metastases in two or more organs. Compared with the median OS of 8 (95%CI, 7.07-8.93) months in the patients with the single site, worse survival of 5 (95%CI, 4.29-5.71) months was noticed in the patients with multiple metastases. Age ≥ 65 years, black race, higher grade, higher T stage and more metastatic sites were proved to be the prognostic factors for all the patients in the advanced stage and the results were partly validated in the validation cohort. Moreover, black race and higher T-stage for the patients with the single metastatic sites and age ≥ 65, uninsured status, surgical treatment and metastatic pattern for the patients with two metastatic sites were prognostic factors. No independent factor was found in patients with three or more metastases. Conclusion: Around 70% of the patients suffered one site distant metastasis in UCC patients with IVB stage while 30% with multiple metastases and a significantly reduced survival. Different survivals and prognostic factors were noticed for different patterns of distant metastases.

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“…Prognostic factors in the cancer patients with distant metastases have been widely studied [14][15][16].…”

Section: Ivyspringmentioning

confidence: 99%

Prognosis for different patterns of distant metastases in patients with uterine cervical cancer: a population-based analysis

Zhang¹,

Guo²,

Zhou³

et al. 2020

J. Cancer

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“…For example, Norgaard et al [4] reported that the 1-year and 5-year survival rates were approximately 47% and 3%, respectively, for PCa patients with bone metastases at initial diagnosis. Apart from PCa, breast and kidney cancers also have a propensity of metastasizing to the bones; and patients with disease that remains confined to the skeleton have a better prognosis than do those with synchronous multiple sites of involvement [8, 9]. However, the sites of synchronous extra-skeletal metastases, e.g., the lung, brain, and liver, and the associated prognostic outcomes in de novo PCa patients with bone metastases have not been thoroughly investigated.…”

Section: Introductionmentioning

confidence: 99%

Sites of synchronous distant metastases and prognosis in prostate cancer patients with bone metastases at initial diagnosis: a population‐based study of 16,643 patients

Zhao

Wang

Chen

et al. 2019

Clinical & Translational Med

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BackgroundBone is a preferential site for prostate cancer (PCa) metastasis. However, sites of synchronous distant metastases in PCa patients with bone metastases at initial diagnosis and their impacts on prognosis are still unclear, limiting our ability to better stratify and treat the patients. In this study, we examined the sites of synchronous extra‐skeletal metastases in de novo PCa patients with bone metastases and their associated prognoses. MethodsIn total, 16,643 de novo PCa patients with bone metastases from the SEER database were included. After stratification of metastatic sites (bone, lung, liver, and brain) and treatment modalities, overall survival (OS) and independent predictors of OS, were analyzed. ResultsLung was the most frequent site of synchronous metastases, followed by liver, while brain metastases were relatively uncommon. Patients with bone‐only metastases showed the longest mean survival time (35.87 months, p < 0.001), followed by patients with bone and lung metastases (30.74 months, p < 0.001). Patients with bone and liver metastases had the shortest mean survival time (17.39 months, p < 0.001). Age > 70 years, unmarried status, high tumor grade, prostate‐specific antigen (PSA) > 50 ng/ml, and Gleason score ≥ 8 were associated with poor OS (all p < 0.01). Asian or Pacific Islander ethnic background was associated with a favorable OS (all p < 0.01). Chemotherapy improved OS in patients without brain metastases (all p < 0.05). For patients with bone‐only metastases, radical prostatectomy (RP) (HR, 0.339; 95% CI 0.231–0.495; p < 0.001), brachytherapy (BT) (HR, 0.567; 95% CI 0.388–0.829; p = 0.003), and chemotherapy (HR, 0.850; 95% CI 0.781–0.924; p < 0.001) were associated with prolonged OS. ConclusionsAge, race, tumor grade, PSA, Gleason score, sites of synchronous extra‐skeletal metastases, as well as treatment modalities affected OS in newly diagnosed PCa patients with bone metastases. Synchronous liver metastases were associated with poor OS. Chemotherapy improved OS in patients without brain metastases. RP and BT improved OS in patients with bone‐only metastases. Further investigation is warranted to validate these findings.

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“…Bone is a common organ for distant metastasis [3,4]. In patients with esophageal cancer, bone metastasis (BM) was reported as the third common metastatic site [5,6].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Homogeneous and Heterogeneous Factors for Bone Metastasis in Esophageal Cancer

Zhang

et al. 2019

Med Sci Monit

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Background: Esophageal cancer is a common cancer worldwide. We performed the present study to assess the homogeneous and heterogeneous risk and prognostic factors of bone metastasis (BM) in esophageal cancer patients using data extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Material/Methods: Data from patients with esophageal cancer in the SEER database from 2010 to 2016 were extracted to reveal the risk factors for BM through univariable and multivariable logistic regression. Cox hazard regression analysis was used to evaluate the prognostic factors in esophageal cancer patients with BM from 2010 to 2015. Results: A total of 2075 (8.0%) patients with initial bone metastasis were diagnosed from among 25 955 patients with esophageal cancer from 2010 to 2016. Male sex, T4 stage, brain metastasis, and liver metastasis were common risk factors for the occurrence and prognosis of BM. Patients with age younger than 67 years, grade III, higher N stage (N1, N2, and N3), histological subtype of esophageal adenocarcinoma or others, and lung metastasis were also more likely to experience bone metastasis, while unmarried patients were associated with shorter survival. Conclusions: The prevalence of initial bone metastasis was approximately 8.0% in esophageal cancer patients. More attention should be paid to patients with revealed risk and prognostic factors because these factors can guide individualize bone metastasis screening and treatment of esophageal cancer patients.

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Incidence of bone metastasis and factors contributing to its development and prognosis in newly diagnosed renal cell carcinoma: a population-based study

Cited by 31 publications

References 15 publications

Prognosis for different patterns of distant metastases in patients with uterine cervical cancer: a population-based analysis

Prognosis for different patterns of distant metastases in patients with uterine cervical cancer: a population-based analysis

Sites of synchronous distant metastases and prognosis in prostate cancer patients with bone metastases at initial diagnosis: a population‐based study of 16,643 patients

Analysis of Homogeneous and Heterogeneous Factors for Bone Metastasis in Esophageal Cancer

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