Incidence of cancer in a nationwide population cohort of 7852 patients with primary Sjögren's syndrome in Taiwan

Abstract

Patients with pSS, overall, did not have higher risk of cancer, and only patients aged 25-44 years were at an increased risk of cancer compared with their counterparts in the general population. Cancer screening for patients with pSS, especially female patients, should focus on NHL and multiple myeloma and thyroid gland cancer.

Primary Sjögren's syndrome and malignancy risk: a systematic review and meta-analysis

“…Some studies examined the association between pSS and overall malignancy risk but no consistent conclusion was drawn 3 11 13 14 16–18 22. The present meta-analysis with more strong evidence confirmed that pSS is closely associated with an increased overall risk of malignancy.…”

“…The result indicated that pSS was associated with a 53% increased risk for overall malignancy (table 2). The Galbraith plot showed that three studies might be major sources of heterogeneity (figure 2), two of which were conducted in Asia18 22 and one in Europe 16. Subgroup analysis showed that there was significant heterogeneity between the two studies in Asia but no heterogeneity in Europe (table 3).…”

“…Second, the RR from hospital-based studies is much higher than from population-based studies, suggesting that the severity of pSS is significantly associated with an increased risk of NHL. Third, only one study examined the risk of NHL in male patients with pSS and found that pSS is not associated with NHL risk 22. It is therefore essential to investigate the association in men with pSS, although this is difficult due to the large predominance of women in pSS.…”

Use of Rituximab in the Management of Sjögren’s Syndrome

“…First, a female gender effect should be taken into account considering that the only one study that investigated the risk of NHL in male patients with pSS found no association. [53]. Secondly, studies in non-European countries are few and included small number of patients.…”

Unusual association of two cases of acute myeloblastic leukaemia and possible Sjogren’s syndrome and review of literature

“…Although many studies have focused on the risk of neoplasia in SS [10][11][12][13][14], we found only four publications in which acute leukaemia was cited ( Table 1) [15][16][17][18]. The first publication reported on a 59-year-old woman with primary SS diagnosed in 1963.…”