Incidence of carbapenem resistant nonfermenting gram negative bacilli from patients with respiratory tract infections among intensive care units

Devi, Pushpa; Reddy, P. Sreenivasulu; John, Maria Sindhura

doi:10.18203/2320-6012.ijrms20150149

Cited by 5 publications

(3 citation statements)

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“…This is comparable to a study reported in India (14.6%). 32 In contrast to our study, a higher rate of studies was reported from India (65%), 33 (30%), 34 Ethiopia (27.1%), 35 and (25%), 36 and lower prevalence studies reported from Ghana (2.9%), 37 Addis Ababa, Ethiopia (2%), 25 Germany (0.22%). 38 This difference might be due to the study period, area, and laboratory method employed.…”

Section: Discussioncontrasting

confidence: 77%

Phenotypic Detection of Carbapenem-Resistant Gram-Negative Bacilli from a Clinical Specimen in Sidama, Ethiopia: A Cross-Sectional Study

Alemayehu

Asnake

Tadesse

et al. 2021

IDR

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Background Carbapenem-resistant gram-negative bacteria are an emergent source of both community-acquired and healthcare-associated infection that poses a substantial hazard to public health. This study aimed to conclude the magnitude of carbapenem resistance gram-negative bacteria from a clinical specimen at Hawassa University Comprehensive Specialized Hospital. Methods A hospital-based cross-sectional study was accompanied from February 13 to June 7, 2020, in which consecutive patients with 103 gram-negative bacteria were encompassed. The isolates included were 54 urine, 17 blood, 17 pusses, 4 cerebrospinal fluid (CSF), 3 aspirates, 3 effusions, 2 stools, 2 ear discharges, and 1 nasal swab. A semi-structured questionnaire was used to gather socio-demographic data from the attendant and clinical data from the patient’s chart. Patients admitted in any wards and visited outpatients department were included for the study if gram-negative bacteria was identified for those who accepted the consent. A routine manual culture, Gram’s staining and biochemical tests used to identify the bacteria. Antibiotic susceptibility was determined for twelve antibiotics including cotrimoxazole, ceftazidime, meropenem, gentamycin, chloramphenicol, ampicillin, ciprofloxacin, cefotaxime, cefuroxime, nitrofurantoin, piperacillin-tazobactam, and amikacin using the Kirby-Bauer disc diffusion method. Modified carbapenem inactivation (mCIM) method was used to determine carbapenem resistance using meropenem disk as per the recommendation of Clinical and Laboratory Standards Institute guideline. Statistical package for social science software version 21 was used for data entry and analysis. The odds ratio at 95% confidence interval (CI) and p-value <0.05 were taken as a statistically significant association. Results Generally, 111 gram-negative bacteria were identified from 103 patients. Of 111 isolates, thirteen isolates (nine resistance and four intermediates) were identified in disk diffusion testing for meropenem. Of this, 10 isolates were carbapenemases producer with the overall rates of 9% in the Modified carbapenem inactivation method (mCIM). Pseudomonas spp. 3 (30.0%), E. coli, K. pneumonia, Acinetobacter spp. each two (20.0%), and K. oxytoca 1 (10.0%) were identified as carbapenemases positive. The rates of the multidrug, extensive, pan drug were 86.5, 43.3, and 1.8, respectively. Ampicillin 94 (97.9%), followed by cefuroxime 52 (91.2%), cefotaxime 94 (88.7%), cotrimoxazole 58 (88.1%), ceftazidime 40 (83.3%), ciprofloxacin 47 (77.1%), nitrofurantoin 35 (70.0%), gentamycin 71 (65.7%), with high level of resistance. However, piperacillin-tazobactam 41 (48.8%), chloramphenicol 25 (47.2%), meropenem 13 (11.7%), and amikacin 9 (8.5%) were with low rates of resistance. In this study, there were no variables statically associated with carbapenem resistance that is p > 0.05. ...

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Section: Discussioncontrasting

confidence: 77%

Phenotypic Detection of Carbapenem-Resistant Gram-Negative Bacilli from a Clinical Specimen in Sidama, Ethiopia: A Cross-Sectional Study

Alemayehu

Asnake

Tadesse

et al. 2021

IDR

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“…In the present study carbapenem resistance was55% with statistically significant difference between surgical ICU and pediatric ICU. Our result also more or less correlates with the study of Devi et al, (2017) who found that 42% of P. aeruginosa isolates were imipenem resistant in surgical ICU and pediatric ICU. On the other hand, lower incidence of carbapenem resistant P. aeruginosa (10.2%) was observed by Lin et al,(2016).…”

Section: Antibiofilm Activity Of Agnps By Clsmsupporting

confidence: 91%

In vitro Study on the Efficacy of Silver Nanoparticles against Metallo-Beta-Lactamase and Biofilm Producing Pseudomonas aeruginosa Isolates

Bahey¹,

Enany²,

Hamid³

et al. 2019

Int.J.Curr.Microbiol.App.Sci

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“…The prevalence of carbapenem-resistance in different parts of India varies from 14-69%. The prevalence of carbapenem-resistant from various countries was found to be around 36% in Egypt [16], 13.6% and 37.9% in Iran [17,18], 56% in Pakistan [19], 24.6% in China [20], 19% in Algeria [21], 2.82% in Turkey [22], 86.3% in Tunis [23], 5.99% in Morocco [24] and 2.9% in Ghana [25], 14.6%, 65%, 30%, in India [26] 27.1% in Ethiopia [27], 0.22% in Germany [28].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Carbapenem-Resistant Hospital Acquired Infections and Their Antimicrobial Susceptibility Pattern in a Tertiary Care Hospital

Bisht

Rajput²,

Jain

2023

J. Pharm. Res. Int.

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Background: The emergence of antimicrobial-resistant bacteria has become a public threat, creating a burden on medical care in hospitals. Carbapenem-resistant organisms are a source of both community-acquired and healthcare-acquired infection that poses a substantial hazard to public health. This study aimed to conclude the prevalence of carbapenem resistance gram-negative bacteria from a clinical specimen at Index Medical College -Indore. Methodology: This study was conducted in the Department of Microbiology, at Index Medical College, Indore, between January 2020 and January 2022.The isolates were subjected to antimicrobial susceptibility tests by Kirby Bauer’s disk diffusion test. Most of the isolates were resistant to beta-lactam drugs, cephalosporin’s and aminoglycosides. These isolates were further confirmedby phenotypic detection usingthe Modified Hodge test, Modified carbapenem Inactivation, Combined disc diffusion test and Double Disk Synergy. Results: The percentage distribution of health-associated infection show highest resistance in both urinary tract and respiratory tract infection, followed by skin & soft tissue infection and least in septicemia and other health associated infection. Highest percentage of resistance was seen in the age group between 21-30 and the least in less than 10 years with a statistical significance of p-value=.00001. The most common isolates recover was E.coli in Enterobacterals and in Non fermenter it was Pseudomonas aeruginosa and Acientobacter. The sensitivity of MHT, mCIM, CDDT, and DDST within CI 95% were 74%, 95%, 84%, and 95% respectively. The overall prevalence of carbapenem resistance is 17.75%. Conclusion: The production of carbapenemase is the major mechanism underlying carbapenem resistance around the world and represents a great health concern. More knowledge is needed to control resistant genes and resistant organisms and their dissemination. There is an urgent need for global collaboration to plan valid strategies to prevent the spread of carbapenemase and the development of new antimicrobial molecules.

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Incidence of carbapenem resistant nonfermenting gram negative bacilli from patients with respiratory tract infections among intensive care units

Cited by 5 publications

References 1 publication

Phenotypic Detection of Carbapenem-Resistant Gram-Negative Bacilli from a Clinical Specimen in Sidama, Ethiopia: A Cross-Sectional Study

Phenotypic Detection of Carbapenem-Resistant Gram-Negative Bacilli from a Clinical Specimen in Sidama, Ethiopia: A Cross-Sectional Study

In vitro Study on the Efficacy of Silver Nanoparticles against Metallo-Beta-Lactamase and Biofilm Producing Pseudomonas aeruginosa Isolates

Prevalence of Carbapenem-Resistant Hospital Acquired Infections and Their Antimicrobial Susceptibility Pattern in a Tertiary Care Hospital

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