Incidence of Childhood Diabetes in Children Aged Less than 15 Years and Its Clinical and Metabolic Characteristics at the Time of Diagnosis: Data from the Childhood Diabetes Registry of Saxony, Germany

Abstract

Aims: The Childhood Diabetes Registry in Saxony, Germany, examined the incidence and metabolic characteristics of childhood diabetes. Methods: In the federal state of Saxony, newly diagnosed cases of diabetes in children and adolescents aged less than 15 years were registered continuously from 1999 until 2008. Family history, date of diagnosis, clinical and laboratory parameters were obtained. Reported cases were ascertained by public health departments as an independent data source and verified using the capture- recapture method. Results: A total of 865 children and adolescents with newly diagnosed diabetes were registered in Saxony. About 96% of them were classified as having type 1 diabetes, 0.6% had type 2 diabetes, 2.4% had maturity-onset diabetes of the young (MODY), and 1.4% had other types of diabetes. The age-standardized incidence rate of type 1 diabetes was estimated at 17.5 per 100,000 children per year. Completeness of ascertainment as calculated by the capture-recapture method amounted to 93.6%. At the time of diagnosis, 27.1% of children with type 1 diabetes had ketoacidosis, 1.5% had a blood pH <7.0, and 1.1% were unconscious. Conclusion: The registry provided data about the incidence rates and clinical presentation of childhood diabetes in a defined German population. We observed higher incidence rates compared to previous surveys.

Maturity onset diabetes of the young: Diagnosis and treatment options

“…The implementation of registry for monogenic diabetes should also be a helpful tool since it provides data about the incidence rates and clinical presentation of diabetes in a particular population [79,80]. It also has low cost and allows collecting a wide range of longitudinal data on rare patients from diverse geographic locations [81].…”

Häufigkeit des Diabetes mellitus im Kindes- und Jugendalter in Deutschland

“…F nordrhein-westfälisches/bundesweites Diabetesregister des Deutschen Diabetes-Zentrums in Düsseldorf [6,35,44], F baden-württembergisches Diabetesregister [9,28,29], F sächsisches Diabetesregister [10,11,12] und F Diabetes-Register Bremen [45,49].…”

A Retrospective Study in 5,989 Patients with Type 1 Diabetes in 10 Outpatient Diabetes Clinics in Sweden of the Frequency of Measuring HbA1c in Clinical Practice

“…There are approximately 385 million people worldwide with diabetes (types 1 and 2), and the prevalence is predicted to rise to 500 million by 2030 [1]. The prevalence of type 1 diabetes mellitus is highest in Scandinavian countries and has increased in several countries during the last decades [2][3][4]. The costs associated with diabetes account for more than 10% of the entire European health budget, with diabetes complications accounting for a major part of these costs [5,6].…”