Incidence of childhood-onset type 1 diabetes in Biscay, Spain, 1990-2013

Abstract

The IR did not increase in this population during the period studied unlike the results in other Spanish regions and European Countries.

Incidence of type 1 diabetes has doubled in Kuwaiti children 0-14 years over the last 20 years

“…For example, data from Sweden collected over 20 years showed a doubling of the incidence from 20 per 100,000 per year to 40 per 100,000 per year, showing a trend similar to that observed in Kuwait. Clearly, our data contribute to the overall conclusion that the global trend of incidence of T1D is still on the rise across the world with a few exceptions such as a recent study from the Biscay region of Spain . Among Kuwaiti children, we found an overall annual increase in T1D incidence of 4.1%, over the last 2 decades.…”

Cyclical variation in the incidence of childhood‐onset type 1 diabetes during 40 years in Navarra (Spain)

“…In recent years, there has been a debate about whether the incidence of T1D is increasing, decreasing, or has stabilized . On the other hand, some authors believe that the incidence seems to be higher because of an earlier onset .…”

“…IAA were determined using a competitive fluid‐phase radioassay which uses [ 125 I]‐labeled recombinant human insulin (Amersham) as antigen and polyethylene glycol for precipitation of immune complexes. GADA (glutamic acid decarboxylase antibodies) and IA2 antibodies were detected using standard radiobinding assay with [ 35 S]‐labeled recombinant human GAD 65 and IA2 antigens obtained by in vitro translation using cDNA clones provided by Dr A. Lernmark (University of Washington, Seattle, WA) and Dr E Bonifacio (Istituto Scientifico San Raffaele, University of Milan, Milan, Italy), respectively …”

Incidence and trend of type 1 diabetes and the underlying environmental determinants

“…A multitude of studies have revealed a pronounced variation trend of T1D incidence with age. For childhood T1D, incidence increases with age and reaches its peak during the age group 10 to 14 years with only limited inconsistency from studies reporting 5 to 9 years as the fastigium . Conversely, T1D incidence decreases after 14 years of age, and such downward trend persists in adulthood .…”

“…T1D was initially recognized as a chronic disease among children and young adolescents, but over time, the perspective that T1D can occur at any age has been gradually accepted . The incidence of childhood T1D has been growing globally since the past few decades though stagnation has also been observed in a small number of regions around the world …”