Incidence of chromosome abnormalities and clinical significance of karyotype in de novo acute myeloid leukemia

Stasi, Roberto; Poeta, Giovanni Del; Masi, M; Tribalto, M; Venditti, Adriano; Papa, G; Nicoletti, B.; Vernole, Patrizia; Tedeschi, Bruna; Delaroche, Isabella; Mingarelli, Rita; Dallapiccola, Bruno

doi:10.1016/0165-4608(93)90040-s

Cited by 77 publications

(39 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several investigations addressing this question have reported significant differences in univariate analyses, but when multivariate models have been used, taking into account other factors, such as age, gender, karyotype, white blood cell and platelet counts, Auer rods, bone marrow cellularity, degree of dysplasia, and percentage of myeloblasts, it has become evident that the FAB subtype is not an independent prognostic factor. 7,25,26,28,31,34,[39][40][41] Thus, our finding that morphologic subgroup did not significantly modify the survival curves for the different cytogenetic prognostic groups agrees well with the results of these previous investigations.…”

Section: Discussionsupporting

confidence: 82%

“…In favor of this conclusion is the relatively high median age (63 years), which exceeds what has been reported in previous studies addressing the prognostic impact of karyotype in AML. 6,9,10,12,[24][25][26][27][28][29][30][31][32][33][34][35][36] It should be stressed, however, that some AML in our region have not been cytogenetically characterized. This group, the size of which may be close to 50%, 37 consists mainly of elderly patients, too frail for curative as well as palliative chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…Age is generally considered to be the most important prognostic factor in AML, 12,[26][27][28][29]31,34,40,42,43 although this has been disputed. 44 The strong impact of age on survival was apparent also in the present study (Figure 3).…”

Section: Leukemiamentioning

confidence: 99%

See 2 more Smart Citations

Survival time in a population-based consecutive series of adult acute myeloid leukemia – the prognostic impact of karyotype during the time period 1976–1993

et al. 2000

View full text Add to dashboard Cite

A consecutive population-based series of 372 adult acute myeloid leukemias, successfully cytogenetically investigated at a single center between 1976 and 1993, is reported. All medical records were reviewed in order to ascertain the prognostic impact of karyotype, divided into three groups; favorable (t(8;21), t(15;17), and inv(16) irrespective of karyotypic complexity; n = 40), poor (der(1;7), inv(3), −5, del(5q), −7, t(9;22), and complex karyotypes including whole or partial losses of chromosomes 5 and/or 7; n = 56), and intermediate (

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Survival time in a population-based consecutive series of adult acute myeloid leukemia – the prognostic impact of karyotype during the time period 1976–1993

et al. 2000

View full text Add to dashboard Cite

show abstract

“…These differences may be related to the very small number of patients in some reports, but more importantly due to the cytogenetic heterogeneity of the cases. In most studies, cases with isolated trisomy 8 were analysed together with patients who showed trisomy 8 and additional other anomalies (Larson et al, 1983;FIWCL, 1984;Bloomfield & de la Chapelle, 1987;Samuels et al, 1988;Fenaux et al, 1989;Stasi et al, 1993;Joventino et al, 1995) (Table III) whereas cases with trisomy 8 in combination with complex anomalies face the worst prognosis. So far only four studies have reported on survival data with þ8 as the sole anomaly (Yunis et al, 1984;Berger et al, 1987;Dastugue et al, 1995;Byrd et al, 1996) (Table IV).…”

Section: Discussionmentioning

confidence: 99%

The significance of trisomy 8 in de novo acute myeloid leukaemia: the accompanying chromosome aberrations determine the prognosis

et al. 1997

View full text Add to dashboard Cite

Trisomy 8 is the most frequent numerical chromosome aberration in acute myeloid leukaemia (AML). It occurs either as the sole anomaly or together with other clonal chromosome aberrations. We investigated whether accompanying chromosome anomalies influence the clinical outcome in patients with trisomy 8 and de novo AML. Since 1986, in 713 AML cases treated according to the protocols of the German AMLCG trials, chromosome analyses have been successfully performed. The overall incidence of trisomy 8 was 7.6%. Complete clinical follow‐up data were available for 51 patients who were divided into three different categories: group 1: trisomy 8 as the sole cytogenetic anomaly (n = 20); group 2: trisomy 8 in addition to favourable chromosome aberrations (t(8;21)(q22;q22), t(15;17)(q22;q21), inv(16)(p13q22)) (n = 10); and group 3: trisomy 8 accompanied by other anomalies, in most cases of complex type (n = 21). Complete remission (CR) rates were 70%, 90% and 67% for groups 1, 2 and 3, respectively. Event‐free survival (EFS) at 3 years differed significantly between patients with trisomy 8 only (37.5%), patients with trisomy 8 in combination with favourable aberrations (55.0%) and patients with trisomy 8 and other accompanying anomalies, mostly complex chromosome aberrations (9.0%) (group 1 v group 2: P = 0.12; group 1 v group 3: P = 0.005; group 2 v group 3: P = 0.05). In this study patients with +8 as the sole cytogenetic anomaly had an intermediate prognosis, patients with +8 in addition to favourable chromosome aberrations maintained a good clinical outcome, and patients with +8 in combination with other abnormalities showed the worst prognosis.

show abstract

“…35 We performed a methotrexate cell synchronization technique and a direct preparation, and examined the chromosomes after Giemsa stain. Whenever possible, at least 20 metaphases were analyzed.…”

Section: Cytogeneticsmentioning

confidence: 99%

Prognostic relevance of the expression of Tdt and CD7 in 335 cases of acute myeloid leukemia

et al. 1998

View full text Add to dashboard Cite

show abstract

Incidence of chromosome abnormalities and clinical significance of karyotype in de novo acute myeloid leukemia

Cited by 77 publications

References 10 publications

Survival time in a population-based consecutive series of adult acute myeloid leukemia – the prognostic impact of karyotype during the time period 1976–1993

Survival time in a population-based consecutive series of adult acute myeloid leukemia – the prognostic impact of karyotype during the time period 1976–1993

The significance of trisomy 8 in de novo acute myeloid leukaemia: the accompanying chromosome aberrations determine the prognosis

Prognostic relevance of the expression of Tdt and CD7 in 335 cases of acute myeloid leukemia

Contact Info

Product

Resources

About