Incidence of common opportunistic infections in HIV-infected individuals in Pune, India: analysis by stages of immunosuppression represented by CD4 counts

Ghate, Manisha; Deshpande, Swapna; Tripathy, Srikanth; Nene, Madhura; Gedam, Preeti; Godbole, Sheela; Thakar, Madhuri; Risbud, Arun; Bollinger, Robert C.; Mehendale, Sanjay

doi:10.1016/j.ijid.2008.03.029

Cited by 90 publications

(100 citation statements)

References 30 publications

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“…Most common presenting complaint of patients in this study was Fever = 30% Present study showed opportunistic infections in 48.3 % of total cases and most common was pulmonary tuberculosis (24/60 = 40%).Manish Ghete et al 13 reported incidence of Opportunistic infection to be 35.7/100 person years and the most common infection in his study was Tuberculosis. Tuberculosis and oral candidiasis are the most commonly reported HIV-related Opportunistic infections in India.…”

Section: Discussionsupporting

confidence: 45%

Role of serum albumin level compared to CD4 cell count as a marker of immunosuppression in HIV/AIDS patients

Singh¹,

Mangla²,

Singh³

et al. 2017

Int. J. Curr. Res. Biol. Med.

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Introduction:-HIV infection is very widespread affecting the human society but due to financial constraints there is a need to identify an alternate prognostic markers of immunosuppression other than CD4+ cell count in HIV. Aims:-To evaluate the role of serum albumin level compared to CD4+ cell count as a markers of immunosuppression in HIV/AIDS patients. Material and Methods:-This prospective follow up case control study included 60 HIV/AIDS patients and controls were age and sex matched normal people. Results:-In our study the mean albumin level was 2.70 ± 0.6, There was a Significant positive correlation between CD4 count and albumin level. p=.037, P<0.001. This suggest that the serum albumin marker could be used as a surrogate marker for immunosuppression in HIV/AIDS patients. Conclusion:-Albumin could be used as a supplementary marker for immunosuppression in HIV/AIDS patients.

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Section: Discussionsupporting

confidence: 45%

Role of serum albumin level compared to CD4 cell count as a marker of immunosuppression in HIV/AIDS patients

Singh¹,

Mangla²,

Singh³

et al. 2017

Int. J. Curr. Res. Biol. Med.

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“…15 In another study, Saurabh et al found the same order of incidence with TB at the top of all the OI's.…”

Section: Discussionmentioning

confidence: 85%

The effect of nevirapine vs efavirenz containing regimens on clinical outcomes among HIV patients on ART: a comparative study

et al. 2017

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Background: The present study has been conducted to compare regimens containing either of nevirapine (NVP) and efavirenz (EFV) and two or more nucleoside reverse transcriptase inhibitors (NRTIs) among HIV infected patients in respect to clinical outcome and to compare incidence of opportunistic infections among these patients.Methods: This study was an observational study conducted at a tertiary care centre over 105 patients, who were evenly matched and received three antiretroviral drug one of the drug was either nevirapine (NVP) or efavirenz (EFV) and these patients were followed up for 6 months for occurrence of any opportunistic infections during these 6 months.Results: 105 patients were followed for 6 months, the maximum incidence of opportunistic infection (OI’s) was found among patients who were on ZLN (zidovudine, lamivudine, nevirapine) regime i.e. 60% followed by patients who changed their regime from ZLN to TLE i.e. 36.5%, while the least incidence of OI’s was noted among the patients who were on TLE (tenofovir, lamivudine, efavirenz) regime i.e. 28.5%. These differences were found to be statistically significant (p<0.05).Conclusions: EFV containing antiretroviral regimen was associated with superior clinical outcome than NVP containing regimen.

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“…Opportunistic infections (OIs) are important co-morbidities in PLWHAs 18 and they influence the morbidity and mortality due to HIV infections. This study showed that in seven of the patients without bacteriuria and four patients with bacteriuria, there was growth of candida in the urine.…”

Section: Discussionmentioning

confidence: 99%

Asymptomatic bacteriuria among HIV positive pregnant women

Awolude

Adesina²,

Oladokun³

et al. 2010

Virulence

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Incidence of common opportunistic infections in HIV-infected individuals in Pune, India: analysis by stages of immunosuppression represented by CD4 counts

Cited by 90 publications

References 30 publications

Role of serum albumin level compared to CD4 cell count as a marker of immunosuppression in HIV/AIDS patients

Role of serum albumin level compared to CD4 cell count as a marker of immunosuppression in HIV/AIDS patients

The effect of nevirapine vs efavirenz containing regimens on clinical outcomes among HIV patients on ART: a comparative study

Asymptomatic bacteriuria among HIV positive pregnant women

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