Incidence of Crohn Disease in the Czech Republic in the Years 1990 to 2001 and Assessment of Pediatric Population with Inflammatory Bowel Disease

Pozler, O; Malý, Jan; Bonova, Oldriska; Dědek, Petr; Frühauf, Pavel; Havlickova, Alena; Janatova, Tatiana; Jimramovský, František; Klimova, Lenka; Klusáček, Dalibor; Kocourkova, Dana; Kolek, Antonín; Kotalová, R; Marx, David; Nevoral, Jiří; Petro, Radim; Petrů, O; Plášilová, Ivana; Seidl, Z; Sekyrová, I; Semendak, Norbert; Schreierova, Irena; Staněk, Jan; Sýkora, Josef; Šuláková, A.; Ťoukálková, Lenka; Travnickova, Radka; Volf, V.; Zahradnicek, Lubomir; Zenisková, Ivana

doi:10.1097/01.mpg.0000189328.47150.bc

Cited by 57 publications

(49 citation statements)

References 16 publications

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“…Prospective data from the USA confirm these findings [11]. The only pediatric studies from central and eastern Europe come from the Czech Republic and show an increasing incidence of CD among children (prospective study, 2000–2001) [12] and an increasing incidence of IBD among children 15 year of age and younger in Moravia, an eastern part of the Czech Republic (1990–2001) [13]. Our clinical observations in Poland permit similar conclusions of a stable increase in the number of newly diagnosed children with IBD.…”

Section: Introductionsupporting

confidence: 59%

Epidemiology of Inflammatory Bowel Disease among Children in Poland

et al. 2009

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Background/Aims: The incidence of pediatric inflammatory bowel disease (IBD) in Western countries is on the rise. No prospective studies have been conducted on the epidemiology of pediatric IBD in Poland. The aim of the study was to define the characteristics of new pediatric IBD and assess the incidence of new IBD among children in Poland between 2002 and 2004. Methods: Patient records from 24 pediatric gastroenterology centers servicing the whole population of Poland were collected. IBD diagnosis was based on clinical, radiological, endoscopic and histological features. Results: There were 491 new IBD patients, representing an overall incidence of IBD of 2.7 cases/100,000 children/year. The incidence of Crohn’s disease (CD) was 0.6, ulcerative colitis (UC) 1.3, and indeterminate colitis (IC) 0.8. The age-related incidence of IBD was 1.8 in the 0- to 10-year-old age group, rising to 3.7 for the 11- to 18-year age group. Conclusions: The overall incidence of IBD (as well as CD, UC and IC) in Poland is lower than that in Western countries. The relative contribution of UC and IC to the overall IBD incidence is higher in Poland than in most Western countries. These findings may suggest a tendency towards under- or misdiagnosis.

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Section: Introductionsupporting

confidence: 59%

Epidemiology of Inflammatory Bowel Disease among Children in Poland

et al. 2009

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“…During follow-up, a trend for an increase in the incidence of CD was observed (from 2.1/10 5 to 2.6/10 5 ), while the incidence of UC remained unchanged (0.8/10 5 ). In Eastern Europe, Pozler et al [44] have recently published the results of a retrospective study investigating the incidence of CD in the Czech Republic in children diagnosed under the age of 15 years between 1990 and 2001. A marked increase in the incidence of CD was reported from 0.25/10 5 in 1990 to 1.25/10 5 in 2001.…”

Section: Most Of the Published Data Come From The Unitedmentioning

confidence: 99%

“…These studies however, have several limitations. Some of them were retrospective surveys [44] , while others were based solely on the in-and outpatient records of a single hospital, extrapolating the results to the investigated area [4] . Patients might have been unnoticed, thus the incidence rate is clearly underestimated.…”

Section: How Can We Explain the Recent Epidemiological Trends?mentioning

confidence: 99%

Recent trends in the epidemiology of inflammatory bowel diseases: Up or down

Lakatos¹

2006

WJG

386

231

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Inflammatory bowel disease (IBD) is traditionally considered to be common in the Western world, and its incidence has sharply increased since the early 1950s. In contrast, until the last decade, low prevalence and incidence rates have been reported from other parts of the world including Eastern Europe, South America, Asia and the Pacific region. Recent trends indicate a change in the epidemiology of IBD with previously low incidence areas now reporting a progressive rise in the incidence, while in West European and North American countries the figures have stabilized or slightly increased, with decreasing incidence rates for ulcerative colitis. Some of these changes may represent differences in diagnostic practices and increasing awareness of the disease. The quality of studies is also variable. Additional epidemiologic studies are needed to better define the burden of illness, explore the mechanism of association with environmental factors, and identify new risk factors.

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“…Recent research from several centers using appropriate laboratory methods showed that most people with chronic inflammation of the intestine of the Crohn's disease type are infected with this chronic enteric pathogen (2,9,53,63,66,67). Like that of Johne's disease, the incidence of Crohn's disease is increasing (43), particularly in children, with recent data from three sites in Northern and Central Europe and in Australia showing increases in the disease in children under 16 which average fivefold per decade (34,56,59).…”

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confidence: 99%

Mycobacterium aviumsubsp.paratuberculosisin Lake Catchments, in River Water Abstracted for Domestic Use, and in Effluent from Domestic Sewage Treatment Works: Diverse Opportunities for Environmental Cycling and Human Exposure

Pickup

Rhodes

Bull

et al. 2006

Appl Environ Microbiol

114

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Mycobacterium avium subsp. paratuberculosis from infected animals enters surface waters and rivers in runoff from contaminated pastures. We studied the River Tywi in South Wales, United Kingdom, whose catchment comprises 1,100 km 2 containing more than a million dairy and beef cattle and more than 1.3 million sheep. The River Tywi is abstracted for the domestic water supply. Between August 2002 and April 2003, 48 of 70 (68.8%) twice-weekly river water samples tested positive by IS900 PCR. In river water, the organisms were associated with a suspended solid which was depleted by the water treatment process. Disposal of contaminated slurry back onto the land established a cycle of environmental persistence. A concentrate from 100 liters of finished water tested negative, but 1 of 54 domestic cold water tanks tested positive, indicating the potential for these pathogens to access domestic outlets. In the separate English Lake District region, with hills up to 980 m, tests for M. avium subsp. paratuberculosis in the high hill lakes and sediments were usually negative, but streams and sediments became positive lower down the catchment. Sediments from 9 of 10 major lakes receiving inflow from these catchments were positive, with sediment cores indicating deposition over at least 40 to 50 years. Two of 12 monthly 1-liter samples of effluent and a single 100-liter sample from the Ambleside sewage treatment works were positive for M. avium subsp. paratuberculosis. Since Lake Ambleside discharges into Lake Windermere, which is available for domestic supply, there is a potential for these organisms to cycle within human populations.

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Incidence of Crohn Disease in the Czech Republic in the Years 1990 to 2001 and Assessment of Pediatric Population with Inflammatory Bowel Disease

Abstract: This study confirmed an increase in incidence of CD in children younger than 15 years in the Czech Republic.

Cited by 57 publications

References 16 publications

Epidemiology of Inflammatory Bowel Disease among Children in Poland

Epidemiology of Inflammatory Bowel Disease among Children in Poland

Recent trends in the epidemiology of inflammatory bowel diseases: Up or down

Mycobacterium aviumsubsp.paratuberculosisin Lake Catchments, in River Water Abstracted for Domestic Use, and in Effluent from Domestic Sewage Treatment Works: Diverse Opportunities for Environmental Cycling and Human Exposure

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