Incidence of Crohn’s disease in Stockholm County 1955–1989

Lapidus, Annika; Bernell, Olle; Hellers, G; Pg, Persson; Löfberg, Robert

doi:10.1136/gut.41.4.480

Cited by 137 publications

(76 citation statements)

References 31 publications

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“…3,[8][9][10][11][12] However, the existence of this second peak has not been reproduced in other studies, including the most recent epidemiologic survey from Olmsted County, Minnesota. [13][14][15][16][17] The recognition of a growing elderly IBD population warrants a critical assessment of the literature used to guide treatment in this unique population.…”

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confidence: 81%

Treatment of Ulcerative Colitis in the Elderly: A Systematic Review

Baggenstos

Hanson²,

Shaukat

2013

Clinical Medicine Insights: Geriatrics

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Ulcerative colitis (UC) is increasingly recognized as a disease affecting the elderly. Approximately 10%-30% of the UC population is over the age of 60 years. Additionally, younger patients with UC are aging and thus comprise a second group of elderly IBD patients. To date, there have been no clinical trials that have evaluated treatment efficacy of UC in the elderly population. The aim of our study was to conduct a systematic review of all randomized controlled trials (RCTs) addressing treatment outcome in UC; we also sought to identify the elderly population, defined as age 60 years or older, represented in these studies, to see if pooled data would lead to meaningful conclusions regarding treatment efficacy and safety profile in the elderly. A search of the MEDLINE database via PubMed and the EMBASE database via Scopus was performed to identify all RCTs evaluating medical therapy for UC in humans, published within the English language through September 2012. Studies were grouped into three categories: biological agent (BA) therapy; immunosuppressant (IS) therapy; and 5-aminosalicylic acid (5-ASA) therapy. To estimate the number of elderly patients in each study, mean age plus 1 and 2 standard deviations (SD) was calculated to find the closest approximation to age 60. Of 876 studies, 112 RCTs were included in the final analysis-20 studies for BA, 20 for IS, and 72 for 5-ASA agents. While nearly all studies reported either a mean or median age, only 38% additionally reported the SD and age range. The mean composite age was 39.2 years for the BA studies, 38.5 years for the IS studies, and 42.8 years for the 5-ASA studies, consistent with a young middle-aged patient. We estimated that no more than 16% of patients per study would have qualified as elderly, and in most cases a much smaller percentage (,8%). Additionally, there were no BA or IS RCTs that reported results by age subgroup analysis. Four studies in the 5-ASA group report age-specific analyses and showed no difference in treatment efficacy by age. None of the 112 RCTs reported age sub-analyses of safety, tolerability, adverse events, or withdrawal rates. There is insufficient evidence to evaluate efficacy of treatment and adverse events from treatment for UC in the elderly. With the rising number of elderly patients with UC, there is a need for more clinical trials that specifically address UC treatment in this unique population.

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mentioning

confidence: 81%

Treatment of Ulcerative Colitis in the Elderly: A Systematic Review

Baggenstos

Hanson²,

Shaukat

2013

Clinical Medicine Insights: Geriatrics

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“…D'une façon habituelle, l'incidence annuelle diminue avec l'âge [3,23] même si l'âge moyen du diagnostic a augmenté au cours du temps, ce qui résulte en partie d'un accroissement de la population âgée en Europe [4,6,19,21].…”

Section: Age D'apparitionunclassified

“…En Suède, le temps moyen écoulé avant l'apparition des symptômes et le diagnostic était de 5 mois avec des extrêmes de 0 à 599 mois [6].…”

Section: Retard De Diagnosticunclassified

“…Néanmoins, dans plusieurs études, une proportion croissante d'affection colorectale a été observée [6,7,9,22].…”

Section: Localisation Des Lésionsunclassified

“…In Stockholm, a study in 1955-1989 showed a mean increase incidence per five years period of 15 % ; during the last two decades of the study period, however the incidence remained stable at a mean of 4.6/10 5 [6].…”

Section: Incidence Over Timementioning

confidence: 99%

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Revue de l'épidémiologie de la maladie de Crohn en Europe

2003

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La maladie de Crohn, une maladie inflammatoire chronique du tube digestif, a une incidence relativement élevée, surtout parmi les sujets jeunes, variant de 0,3 à 9,8 nouveaux cas pour 100 000 personnes en Europe.Les données concernant les variations géographiques, l'incidence au cours des décennies, l'âge de début de la maladie, le délai avant le diagnostic et la localisation de la maladie ont été résumées parmi des travaux effectués en Europe ces dernières années. SUMMARYCrohn's disease, a chronic inflammatory bowel disease of unknown etiology, has a high incidence especially in early adulthood; incidence ranges from 0,3 to 9,8 cases per 10 5 person years in Europe.Geographic variations, incidence over time, male-female ratio, age at onset, delay before diagnosis, disease location and environmental factors have been studied across Europe over last years.Mots-clés : épidémiologie; Europe; maladie de Crohn; maladies inflammatoires chroniques intestinales.

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Global Changes in Incidence

Logan¹,

Armitage²

2006

Challenges in Inflammatory Bowel Disease

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Incidence of Crohn’s disease in Stockholm County 1955–1989

Cited by 137 publications

References 31 publications

Treatment of Ulcerative Colitis in the Elderly: A Systematic Review

Treatment of Ulcerative Colitis in the Elderly: A Systematic Review

Revue de l'épidémiologie de la maladie de Crohn en Europe

Global Changes in Incidence

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