Incidence of diabetes mellitus in a population‐based cohort of persons with chronic hepatitis <scp>B</scp> virus infection

Spradling, Philip R.; Simons, Brenna C.; Narayanan, Meera; Xing, Jian; Homan, Chriss; Bulkow, Lisa; Cagle, Henry H.; Schraer, Cynthia D; McMahon, Brian J.

doi:10.1111/jvh.12071

Cited by 39 publications

(55 citation statements)

References 5 publications

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“…Among these 15 studies, 8 were cross-sectional studies, 5 were case-control studies and 2 were cohort studies. Six studies showed a significantly higher prevalence of DM in HBV-infected patients than in the controls (4-9), 7 studies lacked evidence of a significant association between DM and HBV infection (6,12-17) and 2 studies revealed a lower prevalence of DM in patients with HBV (10,11 (Fig. 1).…”

Section: Methodsmentioning

confidence: 99%

“…A number of studies have identified an association between HBV infection and the prevalence of DM; however, the results of those studies were inconclusive. Certain studies have supported the increased risk of DM in HBV-infected patients when compared with non-HBV-infected controls (4)(5)(6)(7)(8)(9) and certain studies have had different results (10)(11)(12)(13)(14)(15)(16)(17). To the best of our knowledge, no meta-analysis has ever focused on assessing the association between HBV infection and the risk of DM.…”

Section: Introductionmentioning

confidence: 99%

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Association between hepatitis B virus infection and diabetes mellitus: A meta-analysis

Cai

Zeng

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Hepatitis B virus (HBV) infection has been shown by certain studies to be associated with diabetes mellitus (DM); however, the results of these studies were controversial. For that reason, a meta-analysis of the literature was performed in order to determine the association between HBV infection and the prevalence of DM more accurately. The PubMed, Embase, Chinese National Knowledge Infrastructure and Wan Fang databases, as well as the Chinese Science and Technology Journal Database, were searched for literature published until June 2014. The reference lists of all relevant articles were also searched. The summary odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were calculated based on a random-effects model. Heterogeneity was assessed using the I 2 statistic. Subgroup analyses were conducted based on study type and region for the purpose of assessing the factors that could potentially affect the outcome. A total of 15 eligible studies (in 14 articles) were selected for the meta-analysis, involving 12,974,690 HBV-infected patients and 231,776,232 controls. The OR for the prevalence of DM was 1.33 (95% CI, 1.09-1.62; P=0.005) between the patients with HBV infection and the controls. The subgroup analysis based on study type revealed a significantly higher prevalence of DM in the HBV-infected group than that in the control group in both case-control (OR, 1.89; 95% CI, 1.08-3.30; P=0.025) and cross-sectional (OR, 1.41; 95% CI, 1.04-1.90; P=0.027) studies. The subgroup analysis based on region revealed a significantly higher prevalence of DM in the HBV-infected group than in the control group in the Asia-Pacific region (OR, 1.67; 95% CI, 1.08-2.58; P=0.022). Compared with uninfected patients, the pooled results suggest that HBV-infected patients have a higher risk of developing DM; however, given the fact that this is a meta-analysis of observational studies, further randomized controlled trials are required in order to reach a more accurate conclusion.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between hepatitis B virus infection and diabetes mellitus: A meta-analysis

Cai

Zeng

et al. 2015

Experimental and Therapeutic Medicine

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“…Another study reports the incidence rate of DM in Japanese patients with AIH to be 15.0% (28), which is similar to the present study. The risk factors of DM onset in patients with chronic liver disease are reported to be male sex, advanced age and the presence of cirrhosis (13,14,27,29). The present study revealed that advanced age, male sex and corticosteroid use were risk factors of DM (Table 3).…”

Section: Discussionmentioning

confidence: 66%

“…Diabetes mellitus also occasionally occurs in HBV-infected patients; previous studies indicate the prevalence rate of DM is 6.3-12% in HBV infection (13)(14)(15)18). However, a recent population-based cohort study suggested that HBV infection had no effect on DM development (27). Moreover, the prevalence of DM in alcoholic liver disease and NAFLD ranges from 7.4 to 19% (11,19) and 2.5 to 22.5% (11,20), respectively.…”

Section: Discussionmentioning

confidence: 94%

Prevalence and Risk Factors of Diabetes Mellitus in Patients with Autoimmune Hepatitis

et al. 2016

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Objective The administration of corticosteroids is a standard treatment for autoimmune hepatitis (AIH), but it can occasionally induce various adverse effects. Diabetes mellitus (DM) is a major complication of chronic liver diseases. We investigated the prevalence and risk factors of DM in patients with AIH. Methods We retrospectively analyzed 118 Japanese patients diagnosed with AIH from 1990 to 2014 at our institution. The prognosis of patients with and without DM was also compared. Results Twenty-nine (24.5%) patients had DM and 21 (72.4%) received corticosteroids. The annual cumulative incidence rate of newly diagnosed DM was 1.2%. Multivariate analysis showed that DM occurred in older patients [OR=6.290; 95% confidence interval (CI)=1.230-32.100; p=0.018] with higher serum immunoglobulin G levels (OR=12.400; 95% CI=2.560-60.400; p=0.002). A Cox hazard regression analysis revealed that predictive factors for DM were absence of other autoimmune diseases (OR=0.171; 95% CI=0.036-0.805; p=0.025), use of corticosteroids (OR=6.693; 95% CI=1.391-32.210; p=0.049) and lower platelet counts (OR= 3.873; 95% CI=1.021-14.690; p=0.046). The 10 year survival rates of the DM and non-DM groups were 94.1% and 94.6%, respectively. There was no significant difference between these groups (p=0.293). Conclusion DM occurred in 24.5% of patients with AIH; older age, absence of other autoimmune diseases and higher serum immunoglobulin G levels are risk factors. Taking corticosteroids and a lower platelet count are risk factors for a new onset of DM. DM did not influence the prognosis of AIH patients.

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“…Previous studies on patients with hepatitis have also shown significant differences between diabetic and nondiabetic individuals regarding the mean ALT level (18,21), mean age, cirrhosis (23), mean BMI, AST, ALT, HbA1c, cholesterol, and triglyceride (24). Another study on patients with HBV showed that diabetic patients had a significantly higher mean age (47.4 vs. 57 years) and BMI (28.4 vs. 34.5 kg/m 2 ), compared to nondiabetic individuals (25).…”

Section: Discussionmentioning

confidence: 99%

The Prevalence and Risk Factors of Type II Diabetes Mellitus Among Patients with Hepatitis B Virus: A Descriptive Correlational Study

et al. 2017

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Background: There are 350 million carriers of hepatitis B virus (HBV) around the world. HBV can be associated with type II diabetes mellitus. The aim of this study was to evaluate the prevalence and risk factors for type II diabetes mellitus among patients with HBV. Methods: This community-based, cross sectional, descriptive, correlational study recruited participants above 13 years, who resided in Esfandiar rural area, Tabas, Iran. A blood sample was collected from each participant for serological and biochemical tests. A researcher-made questionnaire was used to collect data on the participants' demographic characteristics, HBV risk factors, and diabetes mellitus risk factors. Independent sample t test, Chi square test, and Fisher's exact test were applied in SPSS v. 22.0 at a significance level of < 0.05.

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Incidence of diabetes mellitus in a population‐based cohort of persons with chronic hepatitis B virus infection

Cited by 39 publications

References 5 publications

Association between hepatitis B virus infection and diabetes mellitus: A meta-analysis

Association between hepatitis B virus infection and diabetes mellitus: A meta-analysis

Prevalence and Risk Factors of Diabetes Mellitus in Patients with Autoimmune Hepatitis

The Prevalence and Risk Factors of Type II Diabetes Mellitus Among Patients with Hepatitis B Virus: A Descriptive Correlational Study

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