Incidence of Esophageal Cancer in the United States from 2001-2015: A United States Cancer Statistics Analysis of 50 States

Abstract

IntroductionEsophageal cancer is one of the leading causes of death in males in the United States (US). Previous studies have analyzed incidence rates of esophageal cancer in the US using the data from the National Cancer Institute’s Surveillance, Epidemiology and End Results (SEER) program. However, given its limited patient population, certain groups and regions in the US are underrepresented. Our study utilizes the United States Cancer Statistics (USCS) database, which combines the SEER database with the Centers for Disease Control and Prevention's (CDC) National Program of Cancer Registries (NPCR) to cover all 50 states to examine the incidence of esophageal cancer.MethodsThe USCS registry was used to obtain data for esophageal cancer from 2001 to 2015. Incidence analysis was stratified based on sex, race, stage, histology, and US regional location/histology.ResultsThe overall incidence of esophageal cancer from 2001-2015 was 4.7 per 100,000 people per year. Overall incidence rates were greatest for each stratification in males, blacks, distant disease, adenocarcinoma, and those in the Midwest with adenocarcinoma. Blacks, compared to other races, had the greatest statistically significant decrease in incidence between 2001-2015 (annual percent change (APC) -4.55). The incidence rate is also increasing the most rapidly in those with adenocarcinoma in the Northeast from 2011 to 2015 (APC 2.16).ConclusionIn our study, we were able to determine the incidence of esophageal cancer using data from all 50 states in the US. Our findings of decreasing incidence in blacks and increasing incidence of adenocarcinoma in the Midwest and Northeast help elucidate the at-risk populations. Moreover, our findings help bring to light risk factors that may be contributing to the development of esophageal cancer and how diagnosis and surveillance can be improved based on these risk factors.

Esophageal Cancer: An Updated Surveillance Epidemiology and End Results Database Analysis

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Cancer Associated Macrophage-Like Cells and Prognosis of Esophageal Cancer after Chemoradiation Therapy

“…Esophageal cancer (EC) is the eighth most common cancer histology in the world and sixth for highest mortality rate 1 . In the United States alone there were 17,300 cases of EC with 15,900 deaths in 2018 with an expected 17,700 new cases in 2019 and 18,440 cases in 2020 2,3 . Two major histology subtypes are associated with EC: 1) Adenocarcinoma (EAC), which comprises ~67% of the US patient population and 2) Squamous Cell Carcinoma (SCC), which comprises ~33% 2 .…”

Prognostic value of a five-lncRNA signature in esophageal squamous cell carcinoma

“…In China, the 5-year relative survival of postoperative ESCC patients is 8%-41% [7,8]. Despite recent advances in diagnostic and therapeutic approaches, the life expectancy of ESCC patients has not improved signi cantly [9][10][11]. In addition, the current global diagnosis of ESCC depends on endoscopy and biopsy [12].…”