Incidence of Hypocalcemic Seizures Due to Vitamin D Deficiency in Children in the United Kingdom and Ireland

Basatemür, Emre; Sutcliffe, Alastair

doi:10.1210/jc.2014-2773

Cited by 57 publications

(72 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, South Asian and Black ethnic groups were at the highest risk of symptomatic VDD, but autism with a restricted diet was also noted in only 2 white adolescents with hypocalcemic seizures [20].…”

Section: Discussionmentioning

confidence: 50%

“…Seizures as an initial presentation of Vitamin D Deficiency are uncommon in older children [20], and are rare overall: a recent British publication reports a frequency of 3.49 per million children ages 0-15 (95% CI: 2.81-4.26) in the UK and Ireland [20]. In this study, South Asian and Black ethnic groups were at the highest risk of symptomatic VDD, but autism with a restricted diet was also noted in only 2 white adolescents with hypocalcemic seizures [20].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hypocalcemic Seizure Due to Severe Vitamin-D Deficiency in an Adolescent with Obesity and Autism

Carugno¹,

Ossa²,

Wyllie³

et al. 2018

Clin Pediatr OA

View full text Add to dashboard Cite

Hypocalcemic seizures due to Vitamin D deficiency are rare in children beyond the neonatal period. In this case, a 12 year old female adolescent with intellectual disability, autism, obesity and a very restricted diet presented with hypocalcemic seizure secondary to Vitamin D Deficiency. A higher level of alertness about nutritional deficiencies must be maintained in the presence of dietary restrictions, particularly in children with developmental disabilities.

show abstract

Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Hypocalcemic Seizure Due to Severe Vitamin-D Deficiency in an Adolescent with Obesity and Autism

Carugno¹,

Ossa²,

Wyllie³

et al. 2018

Clin Pediatr OA

View full text Add to dashboard Cite

show abstract

“…Accordingly, we speculated that AEDs, like vitamin D 3 , activated the enzymes of vitamin D metabolism and thereby accelerated the 24-hydroxylation of 25(OH)D 3 , contributing to the loss of vitamin D in epileptic patients. Concerning the lack of sunlight exposure and insufficient intake of vitamin D in epileptic children taking long-term AED therapy, vitamin D deficiency may be aggravated and adverse effects secondary to hypovitaminosis D would be triggered, including rickets, fractures or even hypocalcaemic seizures [54,55] . Physicians should attach considerable importance to screening and correcting vitamin D levels in epileptic children to avoid and mitigate adverse effects.…”

Section: Discussionmentioning

confidence: 99%

Effect of Antiepileptic Therapy on Serum 25(OH)D3 and 24,25(OH)2D3 Levels in Epileptic Children

Jiang²,

Zhu³

et al. 2016

Ann Nutr Metab

View full text Add to dashboard Cite

Background: Vitamin D deficiency is not only associated with the adverse effects of chronic treatment with antiepileptic drugs (AEDs), but also with epilepsy. Although emerging evidence suggests that AEDs can accelerate the vitamin D catabolism, resulting in suboptimal vitamin D status, there are a limited number of studies examining the vitamin D status in epileptic patients, especially in first-episode or AEDs-naïve children. Methods: Determined with high-performance liquid chromatography-tandem mass spectrometry, circulating 25(OH)D₃ and 24,25(OH)₂D₃ levels, and 24,25(OH)₂D₃:25(OH)D₃ ratio were compared between AEDs-treated epileptic (n = 363) and control (n = 159) children. To further figure out whether the patients were in a vitamin D deficient prone state even before treatment, epileptic children before their initiation of treatment (n = 51) were enrolled into a follow-up study. Results: A significant decrease of 25(OH)D₃ and 24,25(OH)₂D₃ levels, but a significant increase of 24,25(OH)₂D₃:25(OH)D₃ ratio was observed in epileptic children, compared with controls. Baseline 25(OH)D₃, 24,25(OH)₂D₃ and 24,25(OH)₂D₃:25(OH)D₃ ratio in the follow-up group were similar to those in controls, but significantly changed with 2 months of AED therapy. Conclusions: Disturbed vitamin D levels were possibly the consequence of AED therapy, rather than the contributing factor of epilepsy. Collectively, circulating vitamin D levels should be monitored and corrected in AEDs-treated epileptic children.

show abstract

“…In a recent national survey in the UK [36], the annual incidence of hypocalcaemic seizures caused by vitamin D deficiency was calculated as 3.49 per million children (age 0e15 y). Of the 91 children reported over a period of 2 years, 27% were neonates and 87% were under 1 year of age.…”

Section: Hypocalcaemic Seizures and Tetanymentioning

confidence: 99%

Complications of vitamin D deficiency from the foetus to the infant: One cause, one prevention, but who's responsibility?

Högler¹

2015

Best Practice & Research Clinical Endocrinology & Metab

View full text Add to dashboard Cite

Incidence of Hypocalcemic Seizures Due to Vitamin D Deficiency in Children in the United Kingdom and Ireland

Cited by 57 publications

References 14 publications

Hypocalcemic Seizure Due to Severe Vitamin-D Deficiency in an Adolescent with Obesity and Autism

Hypocalcemic Seizure Due to Severe Vitamin-D Deficiency in an Adolescent with Obesity and Autism

Effect of Antiepileptic Therapy on Serum 25(OH)D<sub>3</sub> and 24,25(OH)<sub>2</sub>D<sub>3</sub> Levels in Epileptic Children

Complications of vitamin D deficiency from the foetus to the infant: One cause, one prevention, but who's responsibility?

Contact Info

Product

Resources

About