Incidence of IP and risk of malignant transformation in the Swedish population 1960–2010

Elliot, Alexandra; Marklund, Linda; Håkansson, Niclas; Song, Huan; Ye, Weimin; Stjärne, Pär; Hammarstedt‐Nordenvall, Lalle

doi:10.1007/s00405-016-4321-x

Cited by 11 publications

(6 citation statements)

References 19 publications

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“…Sinonasal inverted papilloma (SNIP), as one of the most common benign sinonasal tumors, is characterized by its recurrence tendency, destructive capacity and malignant-transformation possibility (1)(2)(3)(4) . It is well known that the recurrence is mainly caused by incomplete removal of the SNIP (5) , and thus, complete surgical resection, especially the origin of the lesion, is essential for long-term control (3,(5)(6)(7)(8)(9) .…”

Section: Introductionmentioning

confidence: 99%

Pathological changes from the originating to the peripheral sites of Sinonasal Inverted Papilloma are the underlying mechanisms of preoperative MRI-tumor origin prediction

Ma¹,

Xian²,

Yang³

et al. 2019

Rhin

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Background: Our previous study showed that convoluted cerebriform pattern (CCP)-based reverse tracing method in preoperative magnetic resonance imaging (MRI) is a reliable tool in predicting originating site of sinonasal inverted papilloma (SNIP). This study aimed to determine the underlying pathological mechanism of the preoperative MRI-CCP reverse tracing method by assessing the histopathological changes from the origin to the peripheral sites of SNIP. Methodology:The originating site of SNIP was predicted by preoperative MRI in 30 consecutive patients suspected to have primary SNIP. Samples of SNIP originating and peripheral sites were processed by pathological staining for evaluation of stroma score, micro-vessel density (MVD), and tight junction proteins (claudin-5, zonula occludens (ZO)-1 and occludin) expression. Results:The originating site of SNIP was accurately predicted by preoperative MRI in all patients. Stroma scores, and MVD were significantly greater in the periphery of SNIP than in the originating site. In contrast, Claudin-5 expression in micro-vessels was greater at the originating site than the periphery.Conclusions: More edematous stroma and intensive micro-vessels with defective tight junction in periphery of SNIP result in more contrast agent diffusing and CCP that can only be observed at the periphery of SNIP on T2 and contrast-enhanced T1 weighted MR images, which may be the mechanisms underlying the CCP reverse tracing method.

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Section: Introductionmentioning

confidence: 99%

Pathological changes from the originating to the peripheral sites of Sinonasal Inverted Papilloma are the underlying mechanisms of preoperative MRI-tumor origin prediction

Ma¹,

Xian²,

Yang³

et al. 2019

Rhin

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“…In a Swedish population-based study, it was shown that the incidence of SIP has increased from 0.01 to 0.33/100,000 person-years from 1960 to 2010 [14]. Also, the risk of squamous-cell carcinomas in the SIP cohort is significantly higher than in the general population, with a 300-fold increase among male patients with SIP.…”

Section: Discussionmentioning

confidence: 99%

Low Epstein-Barr virus count in sinonasal inverted papilloma

Schindele

Holm

Nylander

et al. 2020

Acta Oto-Laryngologica

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Background: Sinonasal inverted papilloma (SIP) is a benign tumour originating from the sinonasal mucosa showing an extensive growth pattern, a high risk of recurrence and a 5-10% risk to malignify. Epstein-Barr virus (EBV) is an oncogenic herpesvirus which infects most individuals via the saliva eliciting a latent infection. Previous studies have been reporting variable data on EBV in SIP, and there is no present appreciation regarding the association between these. Aims/objectives: The aims were to investigate the presence and count of EBV in SIP and map the viral distribution in the epithelium versus the connective tissue. Material and method: Fifty-three SIP patients were identified in the Pathology Department register at the University Hospital of Umeå. The biopsies were analysed with Epstein-Barr Encoded Region (EBER) in situ hybridization. EBER-positive cells were counted in the epithelium and connective tissue. Results: We found EBER-stained cells in 30% of the cases, where 19% of these had an abundance of stained cells, and the rest showed a low count. Conclusions/significance: These findings demonstrate a low EBV count in SIP. EBV is less likely to be a causative agent in the formation of SIP, or its malignant transformation.

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“…El seguimiento estrecho en consulta y la exploración endoscópica periódica pueden disminuir la recurrencia y evitar, de este modo, la malignización [24]. Nuestro estudio está exento de carcinomas, coincidiendo con numerosos artículos publicados [5,[25][26][27][28][29]. Podría asociarse con una mayor tasa de malignización un diagnóstico tardío, un retraso en el tratamiento o diferentes subtipos de papilomas [1,30].…”

Section: Discussionunclassified

Eficacia del tratamiento quirúrgico del papiloma invertido nasosinusal

Martínez-Ruiz-Coello

Bosco

Amarillo-Espitia

et al. 2022

ORL

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Introducción y objetivo: El papiloma invertido nasosinusal tiene un comportamiento localmente agresivo con riesgo de recidiva, por lo que requiere un tratamiento quirúrgico adecuado y un seguimiento prolongado en consulta. Nuestro objetivo es determinar la eficacia del tratamiento quirúrgico de los papilomas invertidos mediante cirugía endoscópica nasosinusal (CENS), evaluando la incidencia de recurrencia y la persistencia de enfermedad tras la cirugía. Método: Se realiza un estudio retrospectivo de 39 pacientes tratados de papiloma invertido entre 2006 y 2020 en un hospital universitario, registrando datos demográficos y características tumorales. Se analiza la persistencia (antes de 6 meses) o recidiva (después de 6 meses) tras tratamiento quirúrgico. Resultados: El 82% (32/39) de los casos fueron varones y la edad media fue de 54 años. La localización más frecuente fue la pared lateral nasal (38,5%). El 89,7% (35/39) de los casos fue tratado quirúrgicamente mediante CENS, obteniendo un porcentaje de persistencia y recidiva del 2,6%. Un 7,7% (3/39), al ser lesiones del vestíbulo nasal, se resecaron de forma simple. En un caso concreto (2,6%), se necesitó realizar osteoplastia frontal por extensión del papiloma. No se encontró atipia ni malignización en ninguno de los casos. Discusión y conclusiones: El tratamiento quirúrgico de elección del papiloma invertido es la CENS, considerando realizar maxilectomía medial en todos los casos. El tratamiento quirúrgico del PI mediante esta técnica presenta una baja tasa de persistencia y de recurrencia. PALABRAS CLAVE: Papiloma invertido, senos paranasales, cirugía, recidiva, persistencia, malignización, maxilectomía medial.

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Incidence of IP and risk of malignant transformation in the Swedish population 1960–2010

Cited by 11 publications

References 19 publications

Pathological changes from the originating to the peripheral sites of Sinonasal Inverted Papilloma are the underlying mechanisms of preoperative MRI-tumor origin prediction

Pathological changes from the originating to the peripheral sites of Sinonasal Inverted Papilloma are the underlying mechanisms of preoperative MRI-tumor origin prediction

Low Epstein-Barr virus count in sinonasal inverted papilloma

Eficacia del tratamiento quirúrgico del papiloma invertido nasosinusal

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