Incidence of Latex Allergy in Atopic Children and Hospital Workers in Japan

Akasawa, Akira; Matsumoto, Kenji; Saito, Hirohisa; Sakaguchi, Naoya; Tanaka, Kazuaki; Obata, Toshihiko; Tsubaki, Toshikazu; Uchiyama, Hironobu; Matsunaga, Teiichi; K, Kurosaka; Iíkura, Yoji

doi:10.1159/000236516

Cited by 23 publications

(9 citation statements)

References 6 publications

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“…Akasawa et al (15) found latex‐specific IgE in 10.2% atopic children (11/108) with total serum IgE higher than 1000 kU/l and in 0.5% (1/196) of children with total serum IgE of less than 1000 kU/l. In this study, a concordance between latex‐specific skin prick tests and IgE was found in 7 out of 12 sensitized children whereas in the present study only 3 out of 22 children with positive specific IgE also had positive skin prick tests to latex.…”

Section: Discussionmentioning

confidence: 99%

“…Various prevalence studies in children not belonging to the surgical risk group have been carried out in several countries, although using different populations (atopic children, non-atopic children, schoolchildren and allergy clinic children; different age groups) as well as different diagnostic methods (questionnaires, skin prick tests and specific IgE). However, the prevalence of latex allergy in children without surgical risk is low, although it seems to be higher in children with previous atopy (14)(15)(16)(17)(18)(19)(20)(21)(22).…”

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confidence: 99%

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Prevalence of latex sensitization and allergy in Portuguese children

Jorge

Lorente

Taborda-Barata

2006

Pediatric Allergy Immunology

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The prevalence of latex allergy has been increasing not only in risk groups but also in the general population, where it is accepted to average 1%. In children, latex sensitization prevalence studies are scarce and involve different population sampling and allergy testing methods, which makes it difficult to compare across studies. Nevertheless, existing studies point towards a low prevalence of latex allergy in children, which still needs to be confirmed in the Portuguese population. Aiming at studying the prevalence of latex sensitization and allergy in a sample of Portuguese children, we studied 182 children from two different hospital outpatient clinics. A standardized questionnaire focusing on atopic background, previous history and allergic signs or symptoms on exposure to latex or fruits was given to all children and parents. Skin prick testing was performed with a battery of common aeroallergens as well as latex. Serum total IgE, Phadiatop, F x 5E and latex-specific IgE were determined in all children. Specific IgE to latex-crossreacting fruits was determined in latex-sensitized children. Based upon the questionnaire, the prevalence of latex allergy would be 0.5%. The prevalence of latex sensitization would be 3.8%, when based solely upon skin prick testing, and 12.1% (>/=0.35 IU/ml) or 6.6% (>/=0.70 IU/ml) when based singly upon determination of latex-specific IgE. When positive results for either test were considered, the prevalence of latex sensitization was 14.3%. All latex-sensitized children were atopic. Sensitivity to latex-crossreacting foodstuffs was demonstrated in 61.5% of latex-sensitized children (16/26). This study shows that the prevalence of latex allergy and sensitization in Portuguese atopic and non-atopic children, as analysed using various diagnostic methods, is similar to that observed in other countries. In addition, the assessment of latex allergy and sensitization should always include skin prick testing and determination of serum IgE.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Prevalence of latex sensitization and allergy in Portuguese children

Jorge

Lorente

Taborda-Barata

2006

Pediatric Allergy Immunology

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“…IgE-mediated hypersensitivity to latex proteins is an increasing problem, especially among medical personnel, who frequently wear latex gloves (16)(17)(18)(19)(20)(21), as well as in patients with congenital malformations (22-24). In the general population, the prevalence of sensitization to latex proteins was estimated to be around 3.5% (25).…”

Section: Discussionmentioning

confidence: 99%

“…Natural latex is known to contain multiple allergenic proteins in the range 5-100 kDa (16,(33)(34)(35)(36)(37)(38). Rubber elongation factor, hevein and prohevein are known to be major allergens (35,36,39).…”

Section: Discussionmentioning

confidence: 99%

“Latex‐fruit syndrome”: frequency of cross‐reacting IgE antibodies

Brehler

Theissen

Mohr

et al. 1997

Allergy

264

159

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An association between allergies to latex proteins and to various foods has been reported and confirmed by RAST and immunoblotting inhibition. However, no significant data had been collected on the frequency of specific IgE antibodies to fruits in these patients and the frequency of a history of fruit intolerance. Serum samples of 136 patients with well-documented, clinically relevant, immediate-type hypersensitivity against latex proteins were analyzed for IgE antibodies against a panel of different fruits. Patient history of food intolerance was documented by a standardized questionnaire. Fruit-specific IgE antibodies were detected in 69.1% of serum samples. Cross-reacting IgE antibodies recognizing latex and fruit allergens (papaya, avocado, banana, chestnut, passion fruit, fig, melon, mango, kiwi, pineapple, peach, and tomato) were demonstrated by RAST-inhibition tests. Of our patients, 42.5% reported allergic symptoms after ingestion of these fruits and a total of 112 intolerance reactions were recorded. However, fruit-specific IgE antibodies were detected only in serum samples from 32.1% of the patients who perceived symptoms due to these fruits. Thus, serologic tests seem to be of low significance for prediction o food allergy in latex-allergic patients.

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“…Skin prick test reactions and/or specific serum IgE antibodies to NRL without indications of a clinically relevant allergy were found in 121 subjects (24.5%); 97 (80.2%) of these were rated atopic. Other investigators also found that reactions to NRL in the skin prick test (2,18) or NRLspecific serum IgE antibodies (24,25) without a concordant history are seen mainly in atopies. Without a history of NRL allergy and without intense NRL exposure, from 3.75% (18) to 5.0% (2) of atopic subjects exhibit reactions at NRL skin prick testing.…”

Section: Discussionmentioning

confidence: 93%

Natural rubber‐latex allergy in patients not intensely exposed

Ruëff

Thomas

Reissig

et al. 1998

Allergy

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Immediate-type allergy to natural rubber latex (NRL) is common in highly exposed groups, particularly in health-care workers and patients with spina bifida. The occurrence of NRL allergy was investigated in subjects not belonging to such risk groups. A total of 493 patients presenting with various diseases for allergologic evaluation was studied. A questionnaire-based history was taken, skin prick tests with NRL milk and common aeroallergens were done, and NRL-specific serum IgE antibodies were measured. A total of 317 subjects (64.3%) was atopic. There were skin prick test reactions to NRL in 80 (16.2%) and NRL-specific IgE in the serum in 79 (16.0%) subjects; both were found in 25 patients (5.1%). Altogether, NRL sensitization was found in 134 patients (27.2%). By history and/or challenge tests, 13 subjects (2.6%) were diagnosed as having clinically relevant NRL allergy. In five of these, anaphylactic reactions had occurred during dental procedures, and in four during general anesthesia; 10 subjects reported immediate-type reactions to NRL products in daily life. All patients with clinically relevant NRL allergy had a skin prick test reaction to NRL milk (sensitivity 100%). Nine had specific IgE antibodies in the serum (sensitivity 69.2%); respective specificity was 86.0% or 85.4%. Nine of the 13 patients (69.2%) with NRL allergy were atopic. Despite exclusion of those at risk, many patients had clinically relevant allergy to NRL, and many of these had had severe reactions. NRL allergy is an important health issue also beyond the known risk groups.

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Incidence of Latex Allergy in Atopic Children and Hospital Workers in Japan

Cited by 23 publications

References 6 publications

Prevalence of latex sensitization and allergy in Portuguese children

Prevalence of latex sensitization and allergy in Portuguese children

“Latex‐fruit syndrome”: frequency of cross‐reacting IgE antibodies

Natural rubber‐latex allergy in patients not intensely exposed

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