Incidence of Lymphomas and Other Cancers in HIV-Infected and HIV-Uninfected Patients With Hemophilia

Rabkin, Charles S.; Hilgartner, Margaret W.; Hedberg, Katie W.; Aledort, Louis M.; Hatzakis, Angelos; Eichinger, Sabine; Eyster, M. Elaine; White, Gilbert; Kessler, Craig M.; Lederman, Michael M.; Moerloose, Philippe de; Bray, Gordon L.; Cohen, Alan R.; Wa, Andes; Manco‐Johnson, Marilyn J.; Schramm, W.; Kröner, Barbara; Blattner, William A.; Goedert, James J.

doi:10.1001/jama.1992.03480080060027

Cited by 94 publications

(28 citation statements)

References 24 publications

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“…The recognition of this association has prompted the speculation that CKS frequently develops in immunosuppressed persons; the association of the 2 diseases was also suggested to be dependent on a common clinical pattern instead of a common cell of origin, and the 2 possibilities are not mutually exclusive. Chronic leukemia, mainly of lymphocytic type (CLL), was, as expected, the most frequent type in our series: 55% compared with an overall proportion of 33.2% in all Jews of the same age range during the period -1992(Israel Cancer Registry, 1993. Furthermore, patients with a CLL, a B-cell disease where both primary and secondary antibody response are depressed, show a lower mean age at diagnosis than those with other primary neoplasms, related to subsequent CKS.…”

Section: Discussionsupporting

confidence: 80%

“…It is not clear whether lymphomas and KS share an alteration of the phenotype of the infected B-cell; however, KS have been found to be less frequently in individuals who contract HIV through blood transfusion (Beral et al, 1990); however, it was founded by others (Serraino et al, 1992). While it is rare in hemophiliacs population (Rabkin et al, 1992), it have been suggested that HHV-8 (or another 'KS agent') is cellassociated. Here we report a population-based study of secondary CKS in Israel and its association with the type of primary neoplasm and the origin of the patients.…”

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confidence: 99%

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Classic Kaposi's sarcoma as a second primary neoplasm

et al. 1999

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Section: Discussionsupporting

confidence: 80%

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confidence: 99%

Classic Kaposi's sarcoma as a second primary neoplasm

et al. 1999

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“…As the risk of NHL in AIDS and other immunodeficiency states is related to the degree of immune dysregulation (31), it could be that the apparently low risk of HIV-associated lymphoma in Nigeria, as in some other African countries, is the result of competing mortality, particularly from infectious diseases in AIDS patients with relatively low levels of immunosuppression.…”

Section: Discussionmentioning

confidence: 99%

A Fifteen-year Review of Lymphomas in a Nigerian Tertiary Healthcare Centre

Oluwasola¹,

Olaniyi²,

Otegbayo³

et al. 2011

J Health Popul Nutr

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In Africa, epidemiological data on the effect of the HIV epidemic on the occurrence of lymphomas are scanty. The 1990s witnessed the alarming rates of HIV/AIDS in Nigeria. The prevalence of HIV/AIDS in Nigeria increased from 1.8% in 1991 to 4.4% in 2005. The aim of this study was to determine whether there have been any changes in the frequency and pattern of lymphomas in view of the HIV/AIDS epidemic in the country. This is a retrospective study of all lymphoma cases diagnosed during 1991-2005. The prevalence of lymphomas declined from 1.4% to 0.7% of surgical biopsies during 1991-2005. There was a decline in the proportion of high-grade non-Hodgkin lymphoma and Burkitt's lymphoma from 79.1% and 45.8% respectively to 21.1% and 13.6% respectively. There is a suggestion that the HIV/AIDS epidemic in the country may not have influenced the pattern of occurrence of both major histomorphological types of lymphoma in Ibadan.

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“…However, the HIV genome is usually absent in HIV-associated NHL tissue (7,8). The rate of NHL does not generally vary with the risk factor for acquiring HIV infection, but the incidence of both KS and NHL is lower in hemophiliacs infected with HIV than in HIV-positive homosexuals (14,19). Interestingly, an increased risk of developing NHL has been found in patients with KS, herpes simplex virus co-infection and a low neutrophil count (20).…”

Section: Discussionmentioning

confidence: 99%

HIV‐Related Non‐Hodgkin’s Lymphoma in Calgary

Gill

et al. 1995

Canadian Journal of Infectious Diseases and Medical Microbiolog

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OBJECTIVE: To determine the incidence of human immunodeficiency virus (HIV) associated non-Hodgkin’s lymphoma (NHL) in a cohort of patients from a distinct geographic region (southern Alberta). The type and location of NHL as well as how it affected the survival of these patients was examined.PATIENTS AND METHODS: The Southern Alberta HIV Clinic in Calgary serves all of southern Alberta, which has an estimated population of one million. The clinic has provided primary care for 1086 patients from January 1983 to August 1995. Data were obtained by reviewing the clinic’s database and patients’ charts.RESULTS: Over a 12-year period, 39 cases of NHL were diagnosed in a group of 1086 HIV-infected patients. Presentation of NHL was at an extranodal site in all but four cases, with the most common sites being the bowel and central nervous system. The mean CD4 count on presentation with NHL was 143.4±37.4×106/L (range 1 to 1219×106/L). Mean survival was 1.25±0.25 years with a range from 0 (diagnosed on autopsy) to 6.45 years. Patients with a CD4 count of less than 200×106/L and/or diagnosed with an AIDS-defining illness before development of NHL had significantly reduced survival (0.85 years versus 2.48 years, P<0.02 and 0.57 years versus 2.09 years, P<0.001, respectively). Patients who presented with NHL involving either nodes alone or central nervous system had significantly decreased survival (0.28 years and 0.29 years, respectively, P<0.05). Patients with NHL involving the gastrointestinal tract had a longer mean survival than those with NHL elsewhere (P<0.05). All but seven cases received therapy for NHL including chemotherapy, radiotherapy, surgery or combined therapy. Fifteen patients (47% of treated) achieved a complete response that led to improved survival (P<0.01). Patients tolerated surgery, chemotherapy and radiotherapy well and no deaths were due to NHL therapy.CONCLUSIONS: These data suggest that development of NHL in HIV is associated with reduced survival, and that survival is predominantly determined by CD4 count and site of involvement at the time of diagnosis of NHL.

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Incidence of Lymphomas and Other Cancers in HIV-Infected and HIV-Uninfected Patients With Hemophilia

Abstract: HIV infection has restricted effects on cancer incidence that are only partly explained by immunosuppression. Paradoxically, improvements in therapy of HIV infection that prolong survival may lead to further increases in HIV-associated lymphoma.

Cited by 94 publications

References 24 publications

Classic Kaposi's sarcoma as a second primary neoplasm

Classic Kaposi's sarcoma as a second primary neoplasm

A Fifteen-year Review of Lymphomas in a Nigerian Tertiary Healthcare Centre

HIV‐Related Non‐Hodgkin’s Lymphoma in Calgary

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