Incidence of malignancies in biopsy-proven inflammatory myopathy

Kannan, Meena A; Challa, Sundaram; Uppin, Megha S; Mridula, Rukmini; Jabeen, Shagufta; Borgohain, Rupam

doi:10.4103/0028-3886.111121

Cited by 7 publications

(7 citation statements)

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“…The RR for all studies was 1.78 (95% CI: 1.40 to 2.27). The estimate for the 11[20], [21], [22], [23], [24], [25], [30], [31],[32],[33],[35] of DM patients only was 1.59 (95%CI: 1.12 to 2.25).…”

Section: Resultsmentioning

confidence: 99%

“…Summary SMD of CK levels[20], [22], [23], [24], [26], [28], [31], [33], [35], [37] was 0.11 (95% CI: −0.63 to 0.85), indicating no difference between the CK levels of the two groups. The estimate for eight studies[20], [22], [23], [24], [31], [33], [35], [37] involving DM patients only was 0.28 (95% CI: −0.69 to 1.24). Three studies[21], [29], [30] of PM/DM patients reported outcomes as elevated or not.…”

Section: Resultsmentioning

confidence: 99%

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Factors Predicting Malignancy in Patients with Polymyositis and Dermatomyostis: A Systematic Review and Meta-Analysis

et al. 2014

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ObjectiveTo define potential factors that could predict concomitant neoplastic diseases in patients diagnosed with PM/DM, which could inform screening decisions.MethodsTwo researchers independently reviewed articles from Pubmed (MEDLINE), EMBASE, Cochrane Plus Library and ISI Web of Knowledge with no restrictions on study design or language. Given that some of the studies combined PM and DM patients as research subjects while others included only DM patients, data were subjected to meta-analyses for all combined PM/DM studies and studies that included only DM patients to obtain informative results.ResultsFor PM/DM patients, the following factors are all associated with an increased risk of malignancy: older age, age greater than 45, male sex, dysphagia, cutaneous necrosis, cutaneous vasculitis, rapid onset of myostis (<4 weeks), elevated CK, higher ESR, higher CRP levels. Several factors were associated with lower-than-average risk, including the presence of ILD, arthritis/arthralgia, Raynaud's syndrome, or anti-Jo-1 antibody. For DM patients, results indicated an increased risk of malignancy with older age, male sex, the presence of cutaneous necrosis, elevated ESR (>35 mm/hr), higher CRP levels, or anti-p155 antibody. In addition, the presence of anti-ENA antibodies seem to be related to reduced risk of malignancy.ConclusionAwareness and implementation of early-stage cancer screening in PM/DM patients who have these identified factors – such as being older than 45, male sex, cutaneous necrosis, cutaneous vasculitis – are of crucial importance from public health and clinical perspectives and provide insight into the etiopathogenesis of CAM.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Factors Predicting Malignancy in Patients with Polymyositis and Dermatomyostis: A Systematic Review and Meta-Analysis

et al. 2014

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“…The prevalence of malignancy in a biopsy proven series from our institute was reported to be 7% and the most common malignancy was carcinoma breast. [ 12 ]…”

Section: Discussionmentioning

confidence: 99%

Clinico pathological study of adult dermatomyositis: Importance of muscle histology in the diagnosis

Karri

Kannan

Rajashekhar

et al. 2015

Ann Indian Acad Neurol

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Aims:To study the histological features on muscle biopsy and correlate them with clinical features, other laboratory data in adult patients to make a diagnosis of dermatomyositis (DM), applying the European Neuromuscular center (ENMC) criteria.Materials and Methods:Adult patients who fulfilled clinical, laboratory, and muscle biopsy findings according to ENMC criteria for DM during the period 2010–2013 were included in the study. Cryostat sections of muscle biopsy were reviewed with emphasis on Perifascicular atrophy (PFA), perivascular/endomysial inflammation. Muscular dystrophies and metabolic myopathies were excluded by appropriate immunohistochemistry and special stains.Results:The diagnosis of adult DM was made in 45 patients out of 170 clinically suspected idiopathic inflammatory myopathies. These included 33 definite, 4 probable, 7 possible sine dermatitis, and 1 amyopathic DM. All patients with definite DM had typical rash and proximal muscle weakness and muscle biopsy showed PFA with or without inflammation. Thirteen patients had quadriparesis, neck muscle weakness, dysphagia/dysphonia at presentation. Patients with probable DM had rash and showed perivascular/endomysial inflammation with no PFA. Possible DM sine dermatitis showed PFA with perivascular/endomysial infiltrates. One patient of amyopathic DM had typical heliotrope rash and characteristic skin biopsy.Conclusions:Histological features are important for the diagnosis of DM. Relying on PFA for diagnosis of definite DM underestimates the true frequency of DM.

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“…[39][40][41][42] In contrast, PM seldom associates with cancer. 43 Patients with amyopathic dermatomyositis (ADM) have the same cutaneous manifestations as those with classic DM, but without clinical or laboratory evidence of myopathy for at least 6 months. 4,10 Some authors even propose the term "hypomyopathic dermatomyositis" for those DM patients who have no subjective muscle weakness, but with objective evidence of subclinical muscle affection in electromyography or muscle biopsy.…”

Section: Clinical Variantsmentioning

confidence: 99%

Inflammatory Myopathies with Cutaneous Involvement: from Diagnosis to Therapy

Dourmishev¹

2017

Folia Medica

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Incidence of malignancies in biopsy-proven inflammatory myopathy

Abstract: The prevalence of malignancy was very low in our cohort as compared to the studies from other countries. Breast cancer was the most common malignancy associated with DM. The type of associated malignancy was quite variable.

Cited by 7 publications

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Factors Predicting Malignancy in Patients with Polymyositis and Dermatomyostis: A Systematic Review and Meta-Analysis

Factors Predicting Malignancy in Patients with Polymyositis and Dermatomyostis: A Systematic Review and Meta-Analysis

Clinico pathological study of adult dermatomyositis: Importance of muscle histology in the diagnosis

Inflammatory Myopathies with Cutaneous Involvement: from Diagnosis to Therapy

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