Incidence of malignant hyperthermia reactions in 2,214 patients undergoing muscle biopsy

Carr, Alison; Lerman, Jerrold; Cunliffe, Mary; McLeod, M. E.; Britt, Beverley A.

doi:10.1007/bf03010703

Cited by 37 publications

(21 citation statements)

References 17 publications

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“…The five patients with postoperative fever considered by Carr to have had MH all demonstrated temperatures above 38°C. 71 Unfortunately this study failed to document whether pyrexia occurred in other patients. The rate of rise of temperature is of greatest significance, rising as fast as 1°C in five minutes in a MH crisis.…”

Section: Is Postoperative Fever An Indication For Hospital Admission?mentioning

confidence: 81%

“…Grinberg reports the development of postoperative fever in three patients with family histories suspicious of MH 70 while Carr reports five patients with fever in a group of 2,214 patients undergoing muscle biopsy for MHS. 71 All of the reactions occurred in the immediate postoperative period, in the recovery room. Applying the MH clinical grading scale 72 to the clinical details available in these reports only two of these reactions were "very likely" to be MH; the other six were evenly split between "somewhat less than" or "somewhat more than" likely to be MH.…”

Section: Ma Al LI Ig Gn Na An Nt T H Hy Yp Pe Er Rt Th He Er Rm Mi mentioning

confidence: 99%

“…The incidence of MH triggering in MHS patients undergoing a non-triggering anesthetic has been estimated to be less than 1%. 71,73 The Malignant Hyperthermia Association of the United States (MHAUS) advises that the MHS patients may be discharged three to five hours following an uneventful anesthetic. 74 The Malignant Hyperthermia Association of Canada (MHA Canada) recommends a four-hour monitoring period.…”

Section: Ma Al LI Ig Gn Na An Nt T H Hy Yp Pe Er Rt Th He Er Rm Mi mentioning

confidence: 99%

“…77 Mean age of reported cases was 18.3 yr. Children aged less than 15 comprised 52% of the reported cases, and age did not increase the risk of MH. A study of patients undergoing biopsy for MH testing documented a mean age of 32.5 yr. 71 Five patients with postoperative fever were ages three, 12, 15, 24, and 26. Yentis et al studied only children, aged two months to 19 yr and do not document any age-related findings.…”

Section: Is Patient Age a Risk Factor For Mh Triggering In Mhs Patients?mentioning

confidence: 99%

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Patient selection in ambulatory anesthesia — An evidence-based review: part II

et al. 2004

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P Pu ur rp po os se e: : This is the second of two reviews evaluating the management of patients with selected medical conditions undergoing ambulatory anesthesia and surgery. Conditions highlighted in this review include: diabetes mellitus; morbid obesity; the ex-premature infant; the child with an upper respiratory infection; malignant hyperthermia; and the use of monoamine oxidase inhibitors.S So ou ur rc ce e: : Medline search strategies and the framework for the evaluation of clinical evidence are presented in Part I. P Pr ri in nc ci ip pa al l f fi in nd di in ng gs s: : Diabetes mellitus has not been linked with adverse events following ambulatory surgery. The morbidly obese patient is at an increased risk for minor respiratory complications in the perioperative period but these events do not increase unanticipated admissions. The ex-premature infant may be considered for ambulatory surgery if post-conceptual age is > 60 weeks and hematocrit is > 30%. The child with a recent upper respiratory tract infection is at an increased risk for perioperative respiratory complications, particularly if endotracheal intubation is required. Patients with malignant hyperthermia may undergo outpatient surgery but require four hours of postoperative temperature monitoring. Sporadic cases of drug interactions have been reported when meperidine and indirectacting catecholamines are administered in the presence of monamine oxidase inhibitors. Ambulatory anesthesia and surgery is safe if these combinations of drugs are avoided.C Co on nc cl lu us si io on n: : Ambulatory anesthesia can be performed in, and is being offered to, a variety of patients with significant coexistent disease. In many cases there is little evidence documenting the outcomes expected in such patients. Prospective observational and interventional trials are required to better define perioperative management. Objectif : C'est la seconde revue qui évalue la prise en charge de patients, dont les pathologies médicales ont été ciblées, qui doivent subir une anesthésie en chirurgie ambulatoire. Les situations choisies comprennent : le diabète, l'obésité morbide, l'enfant né prématurément, l'enfant atteint d'infection des voies respiratoires supérieures, l'hyperthermie maligne et l'usage d'inhibiteurs de la monoamine-oxydase. Source : Les stratégies de recherche dans Medline et le cadre de l'é-valuation de la preuve clinique sont présentés dans la partie I. Constatations principales : Le diabète n'a pas été relié à des événements indésirables à la suite d'une opération ambulatoire. Le patient très obèse est plus à risque de complications respiratoires péri-opératoires mineures, ce qui n'augmente pas les admissions hospitalières imprévues. L'enfant prématuré est admis en chirurgie ambulatoire si l'âge post-conception est > 60 semaines et si l'hématocrite est > 30 %. L'enfant qui a une infection récente des voies respiratoires supérieures

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Section: Is Postoperative Fever An Indication For Hospital Admission?mentioning

confidence: 81%

Section: Ma Al LI Ig Gn Na An Nt T H Hy Yp Pe Er Rt Th He Er Rm Mi mentioning

confidence: 99%

Section: Ma Al LI Ig Gn Na An Nt T H Hy Yp Pe Er Rt Th He Er Rm Mi mentioning

confidence: 99%

Section: Is Patient Age a Risk Factor For Mh Triggering In Mhs Patients?mentioning

confidence: 99%

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Patient selection in ambulatory anesthesia — An evidence-based review: part II

et al. 2004

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“…Sin embargo, hoy se sabe que la anestesia libre de gatillantes y la adecuada preparación de la máquina de anestesia son seguros; además, el Dantrolene no está libre de efectos adversos, por lo que ya no se indica profilaxis preoperatoria con Dantrolene 22 .…”

Section: Contar Con Protocolos De Manejo Y De Traslado a Unidadeunclassified

Hipertermia maligna: ¿cómo estar preparados?

A¹,

M²,

B³

2013

Rev Chil Cir

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Malignant hyperthermia: how to be prepared?Malignant hyperthermia is an autosomal dominant genetic disease that affects the skeletal muscle. Specifically corresponds to a hypermetabolic response against triggering agents such as halogenated gases and the muscle relaxant succinylcholine. Because MH is a potentially fatal disease and ocurrs unexpectedly during a surgery, it is important to stablish how should be the perioperative management of these patients. The aim of this review is to present the current knowledge about the incidence, pathophysiology and triggers of malignant hyperthermia in addition to concepts for the safe management of these patients.Key words: Malignant hyperthermia, susceptible, diagnosis. ResumenLa hipertermia maligna es una enfermedad genética autosómica dominante que afecta al músculo esquelético. Específicamente corresponde a una respuesta hipermetabólica frente a agentes gatillantes como los gases halogenados y el relajante muscular succinilcolina. Debido a que la HM es una enfermedad potencialmente letal e inesperada, que ocurre durante una cirugía, es importante establecer claramente como debe ser el manejo perioperatorio de estos pacientes. El objetivo de esta revisión es presentar los conocimientos actuales sobre la incidencia, fisiopatología y factores desencadenantes de la hipertermia maligna, además de conceptos para el manejo seguro de estos pacientes.Palabras claves: Hipertermia maligna, susceptibles, diagnóstico. Generalidades DefiniciónLa hipertermia maligna (HM) es una enfermedad genética autosómica dominante que afecta al mús-culo esquelético. Específicamente corresponde a una respuesta hipermetabólica frente a agentes gatillantes como los gases halogenados, el relajante muscular succinilcolina y raramente en humanos frente a ejercicio vigoroso y calor [1][2][3] . IncidenciaLa HM es una enfermedad de baja ocurrencia, pero potencialmente fatal. Con respecto a la inci-

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Malignant Hyperthermia

Bertorini

2013

Neuromuscular Disorders in Clinical Practice

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Incidence of malignant hyperthermia reactions in 2,214 patients undergoing muscle biopsy

Cited by 37 publications

References 17 publications

Patient selection in ambulatory anesthesia — An evidence-based review: part II

Patient selection in ambulatory anesthesia — An evidence-based review: part II

Hipertermia maligna: ¿cómo estar preparados?

Malignant Hyperthermia

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