Incidence of Metabolic Bone Disease After Implementation of Bone Protective Nutritional Strategies: A Prospective Cohort Study

Kolisambeevi, Arif Abdulsalam; Pournami, Femitha; Prithvi, Ajai Kumar; Nandakumar, Anand; Prabhakar, Jyothi; Jain, Naveen

doi:10.1007/s13312-022-2640-0

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Kolisambeevi et al carried out a prospective study with the aim of reducing the incidence of MBD in VLBW infants with gestational age ≤ 30 weeks [ 124 ].…”

Section: Screening and Monitoringmentioning

confidence: 99%

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Prenatal and Neonatal Bone Health: Updated Review on Early Identification of Newborns at High Risk for Osteopenia

Perrone,

Caporilli,

Grassi

et al. 2023

Nutrients

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Bone health starts with maternal health and nutrition, which influences bone mass and density already in utero. The mechanisms underlying the effect of the intrauterine environment on bone health are partly unknown but certainly include the ‘foetal programming’ of oxidative stress and endocrine systems, which influence later skeletal growth and development. With this narrative review, we describe the current evidence for identifying patients with risk factors for developing osteopenia, today’s management of these populations, and screening and prevention programs based on gestational age, weight, and morbidity. Challenges for bone health prevention include the need for new technologies that are specific and applicable to pregnant women, the foetus, and, later, the newborn. Radiofrequency ultrasound spectrometry (REMS) has proven to be a useful tool in the assessment of bone mineral density (BMD) in pregnant women. Few studies have reported that transmission ultrasound can also be used to assess BMD in newborns. The advantages of this technology in the foetus and newborn are the absence of ionising radiation, ease of use, and, above all, the possibility of performing longitudinal studies from intrauterine to extrauterine life. The use of these technologies already in the intrauterine period could help prevent associated diseases, such as osteoporosis and osteopenia, which are characterised by a reduction in bone mass and degeneration of bone structure and lead to an increased risk of fractures in adulthood with considerable social repercussions for the related direct and indirect costs.

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“…Kolisambeevi et al carried out a prospective study with the aim of reducing the incidence of MBD in VLBW infants with gestational age ≤ 30 weeks [ 124 ].…”

Section: Screening and Monitoringmentioning

confidence: 99%

“…The MBD rate is 2.8% in newborns with a gestational age between 28 and 30 weeks and del 69.2% in those with gestational age ≤ 26 weeks. With the results obtained, the authors promote the mandatory early use of phosphorus supplements [ 124 ].…”

Section: Screening and Monitoringmentioning

confidence: 99%

Prenatal and Neonatal Bone Health: Updated Review on Early Identification of Newborns at High Risk for Osteopenia

Perrone,

Caporilli,

Grassi

et al. 2023

Nutrients

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Reducing extrauterine growth restriction in very preterm neonates: A before‐after intervention study

Shrikant,

Gracy,

Pournami

et al. 2024

Nut in Clin Prac

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BackgroundFocus on preterm nutrition strategies is imperative. Extrauterine growth restriction (EUGR) is a clinically relevant, but seemingly elusive consequence, often used to benchmark and compare outcomes.MethodsThis before‐after observational study was designed to study the effect of a multipronged updated “nutrition care bundle” in very preterm infants on rate of EUGR compared with a cohort from a previous period. Eligible participants were neonates born at <32 weeks' gestation who completed care in the unit; a retrospective group from a previous period and a prospective cohort after implementation of the bundle were included. The bundle constituted of three key areas: (1) aggressive parenteral nutrition with high‐dose amino acids and lipids from day 1, (2) “rapid‐escalation” enteral feed regimens including earlier introduction of human milk fortifier (at 40‐ml/kg/day feeds), and (3) colostrum mouth paint and structured oromotor stimulation to promote oral feeding. EUGR was defined as a z score difference of >−1 in weight for postmenstrual age (PMA) at discharge and at birth.ResultsData of 116 infants were retrieved for the retrospective group; 103 infants were included in the prospective group. EUGR was reduced from 71% to 58% (P = 0.039) after implementation of the bundle. Infants in the prospective group achieved full oral feeds at earlier PMA (P < 0.001) and were discharged at earlier PMA (P = 0.002).ConclusionsThe proportion of neonates with EUGR was reduced significantly after implementation of the revised nutrition care bundle. Achievement of full oral feeds and discharge readiness were earlier in the prospective group.

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Metabolic Bone Disease of Prematurity

Pettifor

Thandrayen

2022

Indian Pediatr

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Incidence of Metabolic Bone Disease After Implementation of Bone Protective Nutritional Strategies: A Prospective Cohort Study

Cited by 3 publications

References 20 publications

Prenatal and Neonatal Bone Health: Updated Review on Early Identification of Newborns at High Risk for Osteopenia

Prenatal and Neonatal Bone Health: Updated Review on Early Identification of Newborns at High Risk for Osteopenia

Reducing extrauterine growth restriction in very preterm neonates: A before‐after intervention study

Metabolic Bone Disease of Prematurity

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