Incidence of methicillin resistant Staphylococcus aureus (MRSA) in burn intensive care unit: a systematic review

Abstract

Background Burn victims admitted in burn intensive care units (ICU) are at a high risk of nosocomial infections generated by methicillin resistant Staphylococcus aureus (MRSA). This systematic review aims to estimate the incidence of MRSA among burn patients admitted to the ICU setting, with an emphasis on the incidence rate and antibiotic resistance profile of the MRSA strains.Methods A systematic literature search was performed in five electronic databases limited to publication dates from 1 st January 2000 until 31 st August 2017. After screening n=481 articles, n=21 were found to meet the inclusion criteria of this systematic review.Results Results from the meta-analysis revealed that the risk for MRSA isolates in the burn ICU was 55.0% higher (OR 0.55, 95%CI 0.32-0.94). Therefore, timely testing, appropriate hygiene practice and suggested wound care must be practiced while handling such patients.Conclusion Further studies are needed to identify the risk factors of MRSA infections among burn patients and to develop new antimicrobial agents for MRSA infections.

The global prevalence of Daptomycin, Tigecycline, Quinupristin/Dalfopristin, and Linezolid-resistant Staphylococcus aureus and coagulase–negative staphylococci strains: a systematic review and meta-analysis

“…MRSA is a frequent cause of skin and soft tissue infection, pneumonia, endocarditis, bone and joint infection in individuals with some risk factors such as indwelling devices, surgical interventions, long-term antibiotic use, intensive care admission, and dialysis [121,122]. In recent years, this bacterium has had very high health costs for patients due to increased length of hospital stay and longer duration of antibiotic treatment [123]. Moreover, CoNS are opportunistic pathogens that lead to 30% of hospital-induced infections and 10% of uncomplicated urinary tract infections in young women and native valve endocarditis, especially in immunocompromised patients [124,125].…”

Prognostic Parameters of the Susceptibility of Staphylococcus Spp. To Aminoglycosides and Doxycycline

“…These microorganisms developed resistance to the wide range antibiotics including beta-lactames. They have resistance to methicillin and vancomycin [3,[5][6][7][8].…”

“…Investigation of new antimicrobial drugs for the treatment of infectious complications caused by S. aureus is relevant nowadays. Investigation of the prognostic parameters of the susceptibility to different antibiotics of different clinical isolates of Staphylococcus aureus, that are determined in patients with severe burns, is very important step in the improvement of antimicrobial means against resistant strains of this causative agent, because resistance of MRSA to aminoglycosides and tetracyclines is known [7][8][9][10][11][12][13][14].…”

Molecular Analysis and Integron Carriage of Mupirocin-Resistant Staphylococcus aureus Strains Isolated from Burn Wound Infections, Tehran, Iran

“…Over the past decades, the development and spread of resistance in bacterial pathogens and the identification of their genetic determinants has become a global health concern throughout the world (1). The latest report by the World Health Organization (WHO) showed high levels of resistance in a number of serious bacterial infections in both developed and developing countries.…”

“…The latest report by the World Health Organization (WHO) showed high levels of resistance in a number of serious bacterial infections in both developed and developing countries. One of the major resistant bacteria is Staphylococcus aureus, a common pathogen in both hospital and community that is capable of causing skin and soft tissue infections as well as other life-threatening infections and has gradually evolved towards resistance to many classes of antibiotics (1)(2)(3).…”