The global prevalence of Daptomycin, Tigecycline, Quinupristin/Dalfopristin, and Linezolid-resistant Staphylococcus aureus and coagulase–negative staphylococci strains: a systematic review and meta-analysis

Shariati, Aref; Dadashi, Masoud; Chegini, Zahra; Belkum, Alex van; Mirzaii, Mehdi; Khoramrooz, Seyed Sajjad; Darban-Sarokhalil, Davood

doi:10.1186/s13756-020-00714-9

Cited by 115 publications

(90 citation statements)

References 123 publications

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“…These antibiotics have a strong efficacy against drug-resistant infections caused by gram-positive bacteria, especially MRSA. However, the extensive use of these antibiotics has led to a gradual reduction in the sensitivity of MRSA to these drugs, resulting in the emergence of drug-resistant strains [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Quantification and Pharmacokinetic Study of Five Homologs of Dalbavancin in Rat Plasma Using UHPLC-MS/MS

Zhu

Yang

et al. 2020

Molecules

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Dalbavancin is a novel semisynthetic glycopeptide antibiotic that comprises multiple homologs and isomers of similar polarities. However, pharmacokinetic studies have only analyzed the primary components of dalbavancin, namely B0 and B1. In this study, an ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed to simultaneously determinate and investigate the five homologous components of dalbavancin, namely, A0, A1, B0, B1, and B2, in rat plasma. In this method, methanol was used to precipitate plasma, and a triple-bonded alkyl chromatographic column was used for molecule separation, using 0.1% formic acid-acetonitrile as the mobile phase for gradient elution. Targeted homologs were analyzed by a triple quadrupole mass spectrometer using positive electrospray ionization in multiple reaction monitoring mode. The linearity range was 50–2500 ng/mL with a high correlation coefficient (r2 > 0.998). This method was successfully applied in the pharmacokinetic analysis of dalbavancin hydrochloride to investigate dalbavancin components in rats.

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Section: Introductionmentioning

confidence: 99%

Simultaneous Quantification and Pharmacokinetic Study of Five Homologs of Dalbavancin in Rat Plasma Using UHPLC-MS/MS

Zhu

Yang

et al. 2020

Molecules

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“…We started linezolid after vancomycin treatment failed. A previous study [25] showed that linezolid had the highest inhibitory effect on S. aureus. On the 7th day after starting linezolid treatment, in ammatory biomarker CRP decreased from 120 to 85 mg/L and the body temperature also decreased signi cantly.…”

Section: Discussionmentioning

confidence: 94%

Multi-Site Infections Caused by Methicillin-Resistant Staphylococcus Aureus in a Six-Year Old Girl: A Rare Case Report

Xiao¹,

Liu²,

Yang³

et al. 2021

Preprint

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Background Community-associated Methicillin-resistant Staphylococcus aureus (CA-MRSA) is an emerging pathogen that leads to severe outcomes, especially in pediatric patients with multiple site infections. Case presentation: We report a case of a multiple organ and life-threatening infection caused by CA-MRSA in a 6-year-old girl who manifested sepsis, myelitis, purulent arthritis, purulent meningitis, hydropericardium, pneumonia, and empyema. The girl exhibited good response to the combination therapy of linezolid and rifampicin after treatment with vancomycin failed due to delay in achieving target serum concentration. We performed pleural effusion and hydropericardium effusion drainage and treated left lower limb infection using interdisciplinary approaches. Conclusion This case highlights the need to be aware of CA-MRSA infection, which requires accurate diagnosis, identification of site infection, appropriate antibiotic treatment, and surgical debridement.

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“…In a review article published in 2020, quinupristin/dalfopristin resistance was found as 0.7% (0.3-1%) in MRSA strains 31 . Additionally, in some studies investigating the susceptibility of MRSA to quinupristin/dalfopristin abroad, the rate of resistance was reported to be between 0-31% 13,32,33 32 .…”

Section: Discussionmentioning

confidence: 99%

The Antibiotic Susceptibilities of Methicilline-Resistant Staphylococcus aureus Strains Isolated From Various Clinical Samples

Özbek

Temiz

Özcan

et al. 2021

Preprint

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Background and Objective:: In this study, it was aimed to determine the in vitro susceptibilities of Methicillin-Resistant Staphylococcus aureus (MRSA) strains to fluoroquinolone, linezolid, tigecycline, and quinupristin /dalfopristin as well as the macrolide-lincosamide-streptogramin B (MLSB) resistance phenotype. Materials and Methods A total of 94 MRSA strains isolated from various clinical samples in our hospital laboratory between January 2020 and September 2020 were included. The in-vitro susceptibilities of MRSA strains against fluoroquinolone, linezolid, tigecycline, and quinupristin/dalfopristin were determined by Kirby-Bauer disc diffusion assay according to The European Committee on Antimicrobial Susceptibility Testing (EUCAST). The E test assay was used for evaluation of tigecycline susceptibility. The D-zone test was performed with erythromycin (15 µg) and clindamycin (2 µg) discs to determine the MLSB resistance. Besides, bacterial identification, antibiotic susceptibility tests including methicillin resistance and MLSB phenotype determination were performed by using VİTEK 2 Gram-positive diagnostic kits(Bio-Mérieux/France). Results Results: Among 94 MRSA strains included, resistance rates to ciprofloxacin, moxifloxacin, tigecycline, and quinupristin/dalfopristin were found as 71% (67 isolates) 64%(60 isolates), 17%(16 isolates), and 2% (2 isolates), respectively.. Resistance was not detected for linezolid. A total of 36(49%) isolates showed cMLSB resistance phenotype while 18(19%) had iMLSB resistance. The MS phenotype – strains resistant to erythromycin and susceptible to clindamycin- was not detected. Conclusion Very little or no resistance was found to linezolid, quinupristin/dalfopristin and tigecycline. Therefore, these antibiotics may be beneficial for the proper treatment of infections caused by MLSB-resistant isolates.

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The global prevalence of Daptomycin, Tigecycline, Quinupristin/Dalfopristin, and Linezolid-resistant Staphylococcus aureus and coagulase–negative staphylococci strains: a systematic review and meta-analysis

Abstract: Objective: Methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative

Cited by 115 publications

References 123 publications

Simultaneous Quantification and Pharmacokinetic Study of Five Homologs of Dalbavancin in Rat Plasma Using UHPLC-MS/MS

Simultaneous Quantification and Pharmacokinetic Study of Five Homologs of Dalbavancin in Rat Plasma Using UHPLC-MS/MS

Multi-Site Infections Caused by Methicillin-Resistant Staphylococcus Aureus in a Six-Year Old Girl: A Rare Case Report

The Antibiotic Susceptibilities of Methicilline-Resistant Staphylococcus aureus Strains Isolated From Various Clinical Samples

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