Incidence of Nonmelanoma Skin Cancer After Human Organ Transplantation: Single-Center Experience in Hungary

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“…[5][6][7]26 Some studies have reported higher ratios of basal to squamous cell carcinoma in kidney transplant recipients. 3,8,20,27 In the present study, squamous and basal cell carcinoma had similar frequency (ratio of squamous to basal cell carcinoma, 1.1:1). There were no significant differences in sex, age at transplant, and immunosuppressive treatment between patients who developed squamous or basal cell carcinoma, and both squamous and basal cell carcinoma occurred on sun exposed areas of the skin.…”

“…Age also may be an important risk factor for the development of skin cancer after transplant, with a reported 12-fold greater risk in patients aged > 55 years compared with patients aged < 35 years at transplant. 24 Although some studies have reported similar findings, 3,4,8,20 other studies have not shown the same association. 6,7 The mean age at transplant in the current study was 38 ± 14 years, and the age at transplant was significantly lower in patients who developed Kaposi sarcoma than epithelial skin malignancies ( Table 2).…”

“…The incidence of nonmelanoma skin cancer may be greater in patients who receive cyclosporine than azathioprine or tacrolimus, 13,[18][19][20] but some studies have shown no significant difference in the incidence of skin cancer between patients who received azathioprine or cyclosporine therapy. 1,8,[21][22][23] In the present study, different combinations of immunosuppressive therapies were given to kidney transplant recipients, and there were no significant differences in histologic subtypes of tumors, time from transplant to skin cancer diagnosis, or prognosis between patients having different immunosuppressive treatment.…”

Incidence, Risk Factors, and Preventative Management of Skin Cancers in Organ Transplant Recipients: A Review of Single- and Multicenter Retrospective Studies from 2006 to 2010

“…10,26 Two studies reported an approximately 1:1 27,28 BCC:SCC ratio for diagnosed NMSC cancers, possibly because of short follow-up. The reasons for the higher BCC:SCC ratio have not been well elucidated, although two of the studies indicate that the small sample size may be a cause of for the ratio discrepancy.…”

“…The reasons for the higher BCC:SCC ratio have not been well elucidated, although two of the studies indicate that the small sample size may be a cause of for the ratio discrepancy. 19,29,30 The primary anatomic NMSC location reported is the head and neck 10,22,23,31 ; other common areas include the upper limbs, trunk, and other sun-exposed areas. 28 The mean age of diagnosis of a first NMSC since transplantation has varied between studies, with reports of between 4 and 9 years after kidney transplantation.…”